Evaluation of HIV protease inhibitor use and the risk of sudden death or nonhemorrhagic stroke

S W Worm; D A Kamara; P Reiss; E Fontas; S De Wit; W El-Sadr; A D'Arminio Monforte; M Law; A Phillips; L Ryom; F Dabis; Roy E. Weber; C Sabin; J D Lundgren; D:A:D Study Group

doi:10.1093/infdis/jir788

Evaluation of HIV protease inhibitor use and the risk of sudden death or nonhemorrhagic stroke

S W Worm, D A Kamara, P Reiss, E Fontas, S De Wit, W El-Sadr, A D'Arminio Monforte, M Law, A Phillips, L Ryom, F Dabis, Roy E. Weber, C Sabin, J D Lundgren, D:A:D Study Group

25 Citations (Scopus)

Abstract

Concerns have arisen about possible effects of protease inhibitors (PIs) on cardiac conductivity. We found no significant association between current or recent PI exposure and sudden death or nonhemorrhagic stroke (adjusted rate ratio, 1.22; 95% confidence interval, .95-1.57), whereas cumulative exposure to PIs was associated with an increased risk (adjusted rate ratio, 1.06 per year of exposure; 95% confidence interval, 1.01-1.11).

Original language	English
Journal	The Journal of Infectious Diseases
Volume	205
Issue number	4
Pages (from-to)	535-9
Number of pages	5
ISSN	0022-1899
DOIs	https://doi.org/10.1093/infdis/jir788
Publication status	Published - 15 Feb 2012

Keywords

Adult
Death, Sudden
Female
HIV Infections
HIV Protease Inhibitors
Humans
Male
Middle Aged
Risk Assessment
Stroke

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/infdis/jir788

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Worm, S. W., Kamara, D. A., Reiss, P., Fontas, E., De Wit, S., El-Sadr, W., D'Arminio Monforte, A., Law, M., Phillips, A., Ryom, L., Dabis, F., Weber, R. E., Sabin, C., Lundgren, J. D., & D:A:D Study Group (2012). Evaluation of HIV protease inhibitor use and the risk of sudden death or nonhemorrhagic stroke. The Journal of Infectious Diseases, 205(4), 535-9. https://doi.org/10.1093/infdis/jir788

Worm, SW, Kamara, DA, Reiss, P, Fontas, E, De Wit, S, El-Sadr, W, D'Arminio Monforte, A, Law, M, Phillips, A, Ryom, L, Dabis, F, Weber, RE, Sabin, C, Lundgren, JD & D:A:D Study Group 2012, 'Evaluation of HIV protease inhibitor use and the risk of sudden death or nonhemorrhagic stroke', The Journal of Infectious Diseases, vol. 205, no. 4, pp. 535-9. https://doi.org/10.1093/infdis/jir788

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abstract = "Concerns have arisen about possible effects of protease inhibitors (PIs) on cardiac conductivity. We found no significant association between current or recent PI exposure and sudden death or nonhemorrhagic stroke (adjusted rate ratio, 1.22; 95% confidence interval, .95-1.57), whereas cumulative exposure to PIs was associated with an increased risk (adjusted rate ratio, 1.06 per year of exposure; 95% confidence interval, 1.01-1.11).",

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AU - Worm, S W

AU - Kamara, D A

AU - Reiss, P

AU - Fontas, E

AU - De Wit, S

AU - El-Sadr, W

AU - D'Arminio Monforte, A

AU - Law, M

AU - Phillips, A

AU - Ryom, L

AU - Dabis, F

AU - Weber, Roy E.

AU - Sabin, C

AU - Lundgren, J D

AU - D:A:D Study Group

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AB - Concerns have arisen about possible effects of protease inhibitors (PIs) on cardiac conductivity. We found no significant association between current or recent PI exposure and sudden death or nonhemorrhagic stroke (adjusted rate ratio, 1.22; 95% confidence interval, .95-1.57), whereas cumulative exposure to PIs was associated with an increased risk (adjusted rate ratio, 1.06 per year of exposure; 95% confidence interval, 1.01-1.11).

KW - Adult

KW - Death, Sudden

KW - Female

KW - HIV Infections

KW - HIV Protease Inhibitors

KW - Humans

KW - Male

KW - Middle Aged

KW - Risk Assessment

KW - Stroke

U2 - 10.1093/infdis/jir788

DO - 10.1093/infdis/jir788

M3 - Journal article

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SN - 0022-1899

VL - 205

SP - 535

EP - 539

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 4

ER -

Evaluation of HIV protease inhibitor use and the risk of sudden death or nonhemorrhagic stroke

Abstract

Keywords

UN SDGs

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