Evaluation of different substrates for inkjet printing of rasagiline mesylate.

Natalja Genina; Eva Maria Janßen; Armin Breitenbach; Jörg Breitkreutz; Niklas Sandler

doi:10.1016/j.ejpb.2013.03.017

Evaluation of different substrates for inkjet printing of rasagiline mesylate.

Natalja Genina, Eva Maria Janßen, Armin Breitenbach, Jörg Breitkreutz, Niklas Sandler

72 Citations (Scopus)

Abstract

The main goal of the present study was to evaluate applicability of the different model substrates, namely orodispersible films (ODFs), porous copy paper sheets, and water impermeable transparency films (TFs) in preparation of the inkjet-printed drug-delivery systems. Rasagiline mesylate (RM) was used as a low-dose active pharmaceutical ingredient (API). Flexible doses of the drug in a single unit were obtained by printing several subsequent layers on top of the already printed ones, using an off-the-shelf consumer thermal inkjet (TIJ) printer. The produced drug-delivery systems were subjected to microscopic and chemical analysis together with solid-state characterization and content uniformity studies. The results revealed that RM recrystallized on the surface of ODFs and TFs, and the printed crystals were arranged in lines. No drug crystals were detected after printing on the surface of the copy paper due to absorption of the ink into the matrix of the substrate. The best linear correlation between the dose of the drug and the number of the printing layers was obtained for the porous copy paper. The other two substrates showed poor linearity and unacceptable standard deviations of the printed drug substance due to limited absorption of the API ink into the carrier. The shear stress between the substrate, the print head, and the paper feeding rollers caused smearing of the drug that had been surface-deposited during the earlier printing cycles. In conclusion, this study indicates that the edible substrates with absorption properties similar to copy paper are favorable for successful preparation of drug-delivery systems by TIJ printers.

Original language	English
Journal	European Journal of Pharmaceutics and Biopharmaceutics
Volume	85
Issue number	3 Pt B
Pages (from-to)	1075-83
Number of pages	9
ISSN	0939-6411
DOIs	https://doi.org/10.1016/j.ejpb.2013.03.017
Publication status	Published - Nov 2013

Keywords

Absorption
Administration, Oral
Antiparkinson Agents
Antiparkinson Agents: chemistry
Chemistry, Pharmaceutical
Chemistry, Pharmaceutical: methods
Drug Delivery Systems
Indans
Indans: chemistry
Ink
Mesylates
Mesylates: chemistry
Microscopy, Electron, Scanning
Pharmaceutical Preparations
Pharmaceutical Preparations: chemistry
Porosity
Printing
Printing: methods
Stress, Mechanical
Surface Properties
Viscosity
X-Ray Diffraction

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10.1016/j.ejpb.2013.03.017

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title = "Evaluation of different substrates for inkjet printing of rasagiline mesylate.",

abstract = "The main goal of the present study was to evaluate applicability of the different model substrates, namely orodispersible films (ODFs), porous copy paper sheets, and water impermeable transparency films (TFs) in preparation of the inkjet-printed drug-delivery systems. Rasagiline mesylate (RM) was used as a low-dose active pharmaceutical ingredient (API). Flexible doses of the drug in a single unit were obtained by printing several subsequent layers on top of the already printed ones, using an off-the-shelf consumer thermal inkjet (TIJ) printer. The produced drug-delivery systems were subjected to microscopic and chemical analysis together with solid-state characterization and content uniformity studies. The results revealed that RM recrystallized on the surface of ODFs and TFs, and the printed crystals were arranged in lines. No drug crystals were detected after printing on the surface of the copy paper due to absorption of the ink into the matrix of the substrate. The best linear correlation between the dose of the drug and the number of the printing layers was obtained for the porous copy paper. The other two substrates showed poor linearity and unacceptable standard deviations of the printed drug substance due to limited absorption of the API ink into the carrier. The shear stress between the substrate, the print head, and the paper feeding rollers caused smearing of the drug that had been surface-deposited during the earlier printing cycles. In conclusion, this study indicates that the edible substrates with absorption properties similar to copy paper are favorable for successful preparation of drug-delivery systems by TIJ printers.",

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author = "Natalja Genina and Jan{\ss}en, {Eva Maria} and Armin Breitenbach and J{\"o}rg Breitkreutz and Niklas Sandler",

year = "2013",

month = nov,

doi = "10.1016/j.ejpb.2013.03.017",

language = "English",

volume = "85",

pages = "1075--83",

journal = "European Journal of Pharmaceutics and Biopharmaceutics",

issn = "0939-6411",

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TY - JOUR

T1 - Evaluation of different substrates for inkjet printing of rasagiline mesylate.

AU - Genina, Natalja

AU - Janßen, Eva Maria

AU - Breitenbach, Armin

AU - Breitkreutz, Jörg

AU - Sandler, Niklas

PY - 2013/11

Y1 - 2013/11

N2 - The main goal of the present study was to evaluate applicability of the different model substrates, namely orodispersible films (ODFs), porous copy paper sheets, and water impermeable transparency films (TFs) in preparation of the inkjet-printed drug-delivery systems. Rasagiline mesylate (RM) was used as a low-dose active pharmaceutical ingredient (API). Flexible doses of the drug in a single unit were obtained by printing several subsequent layers on top of the already printed ones, using an off-the-shelf consumer thermal inkjet (TIJ) printer. The produced drug-delivery systems were subjected to microscopic and chemical analysis together with solid-state characterization and content uniformity studies. The results revealed that RM recrystallized on the surface of ODFs and TFs, and the printed crystals were arranged in lines. No drug crystals were detected after printing on the surface of the copy paper due to absorption of the ink into the matrix of the substrate. The best linear correlation between the dose of the drug and the number of the printing layers was obtained for the porous copy paper. The other two substrates showed poor linearity and unacceptable standard deviations of the printed drug substance due to limited absorption of the API ink into the carrier. The shear stress between the substrate, the print head, and the paper feeding rollers caused smearing of the drug that had been surface-deposited during the earlier printing cycles. In conclusion, this study indicates that the edible substrates with absorption properties similar to copy paper are favorable for successful preparation of drug-delivery systems by TIJ printers.

AB - The main goal of the present study was to evaluate applicability of the different model substrates, namely orodispersible films (ODFs), porous copy paper sheets, and water impermeable transparency films (TFs) in preparation of the inkjet-printed drug-delivery systems. Rasagiline mesylate (RM) was used as a low-dose active pharmaceutical ingredient (API). Flexible doses of the drug in a single unit were obtained by printing several subsequent layers on top of the already printed ones, using an off-the-shelf consumer thermal inkjet (TIJ) printer. The produced drug-delivery systems were subjected to microscopic and chemical analysis together with solid-state characterization and content uniformity studies. The results revealed that RM recrystallized on the surface of ODFs and TFs, and the printed crystals were arranged in lines. No drug crystals were detected after printing on the surface of the copy paper due to absorption of the ink into the matrix of the substrate. The best linear correlation between the dose of the drug and the number of the printing layers was obtained for the porous copy paper. The other two substrates showed poor linearity and unacceptable standard deviations of the printed drug substance due to limited absorption of the API ink into the carrier. The shear stress between the substrate, the print head, and the paper feeding rollers caused smearing of the drug that had been surface-deposited during the earlier printing cycles. In conclusion, this study indicates that the edible substrates with absorption properties similar to copy paper are favorable for successful preparation of drug-delivery systems by TIJ printers.

KW - Absorption

KW - Administration, Oral

KW - Antiparkinson Agents

KW - Antiparkinson Agents: chemistry

KW - Chemistry, Pharmaceutical

KW - Chemistry, Pharmaceutical: methods

KW - Drug Delivery Systems

KW - Indans

KW - Indans: chemistry

KW - Ink

KW - Mesylates

KW - Mesylates: chemistry

KW - Microscopy, Electron, Scanning

KW - Pharmaceutical Preparations

KW - Pharmaceutical Preparations: chemistry

KW - Porosity

KW - Printing

KW - Printing: methods

KW - Stress, Mechanical

KW - Surface Properties

KW - Viscosity

KW - X-Ray Diffraction

U2 - 10.1016/j.ejpb.2013.03.017

DO - 10.1016/j.ejpb.2013.03.017

M3 - Journal article

C2 - 23563101

SN - 0939-6411

VL - 85

SP - 1075

EP - 1083

JO - European Journal of Pharmaceutics and Biopharmaceutics

JF - European Journal of Pharmaceutics and Biopharmaceutics

IS - 3 Pt B

ER -

Evaluation of different substrates for inkjet printing of rasagiline mesylate.

Abstract

Keywords

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