Evaluation of aortic valve stenosis by cardiac multislice computed tomography compared with echocardiography: a systematic review and meta-analysis

Jawdat Abdulla; Jacob Sivertsen; Klaus Fuglsang Kofoed; Hatem Alkadhi; Troy LaBounty; Steen Z Abildstrom; Lars Valeur Køber; Erik Christensen; Christian Torp-Pedersen; Jawdat Abdulla; Jacob Christian Sivertsen; Klaus Fuglsang Kofoed; Hatem Alkadhi; Troy LaBounty; Steen Z Abildstrom; Lars Kober; Erik Christensen; Christian Torp-Pedersen

Evaluation of aortic valve stenosis by cardiac multislice computed tomography compared with echocardiography: a systematic review and meta-analysis

Jawdat Abdulla, Jacob Sivertsen, Klaus Fuglsang Kofoed, Hatem Alkadhi, Troy LaBounty, Steen Z Abildstrom, Lars Valeur Køber, Erik Christensen, Christian Torp-Pedersen, Jawdat Abdulla, Jacob Christian Sivertsen, Klaus Fuglsang Kofoed, Hatem Alkadhi, Troy LaBounty, Steen Z Abildstrom, Lars Kober, Erik Christensen, Christian Torp-Pedersen

27 Citations (Scopus)

Abstract

BACKGROUND AND AIM OF THE STUDY: It has not yet been established whether multi-slice computed tomography (MSCT) is reliable for the quantification of aortic valve area (AVA) in patients with aortic valve stenosis (AVS) and simultaneously for assessment of the coronary anatomy. The study aim, via a systematic literature review and meta-analysis, was to explore whether MSCT is a reliable method for AVA quantification, and simultaneously to assess the coronary anatomy in patients with AVS. METHODS: A comprehensive systematic literature search and meta-analysis was conducted that included 14 studies totaling 470 patients. The meta-analysis was carried out to examine the reliability of MSCT compared to transthoracic echocardiography (TTE) and transesophageal echocardiography (TEE). Seven studies including 266 patients with AVS were also eligible for a secondary analysis to compare the accuracy of MSCT with invasive coronary angiography. RESULTS: The AVA was measured by MSCT and TTE in all 14 studies, and by TEE in four studies. The results of the meta-analyses showed that planimetry by MSCT overestimated the AVA, with a bias of 0.08 (95% CI 0.04, 0.13) cm2) (p = 0.0001) compared to TTE. The MSCT measurement was concordant with planimetry by TEE, with a small bias of -0.02 (95% CI -0.16, 0.11) cm2 (p = 0.71). MSCT, when compared to invasive angiography for the detection of significant coronary stenosis, showed sensitivity, specificity and diagnostic odds ratio of 95.5% (95% CI 88-99), 81% (95% CI 75-86)%, and 53 (95% CI 19-147), respectively. CONCLUSION: MSCT is a reliable method for the quantification of AVA, and represents a promising technique for the combined evaluation of aortic valve morphology and coronary artery disease.

Original language	English
Journal	Journal of Heart Valve Disease
Volume	18
Issue number	6
Pages (from-to)	634-43
Number of pages	9
ISSN	0966-8519
Publication status	Published - 2009

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Abdulla, J., Sivertsen, J., Kofoed, K. F., Alkadhi, H., LaBounty, T., Abildstrom, S. Z., Køber, L. V., Christensen, E., Torp-Pedersen, C., Abdulla, J., Sivertsen, J. C., Kofoed, K. F., Alkadhi, H., LaBounty, T., Abildstrom, S. Z., Kober, L., Christensen, E., & Torp-Pedersen, C. (2009). Evaluation of aortic valve stenosis by cardiac multislice computed tomography compared with echocardiography: a systematic review and meta-analysis. Journal of Heart Valve Disease, 18(6), 634-43.

Evaluation of aortic valve stenosis by cardiac multislice computed tomography compared with echocardiography: a systematic review and meta-analysis. / Abdulla, Jawdat; Sivertsen, Jacob; Kofoed, Klaus Fuglsang et al.

In: Journal of Heart Valve Disease, Vol. 18, No. 6, 2009, p. 634-43.

Research output: Contribution to journal › Journal article › Research › peer-review

Abdulla, J, Sivertsen, J, Kofoed, KF, Alkadhi, H, LaBounty, T, Abildstrom, SZ, Køber, LV, Christensen, E, Torp-Pedersen, C, Abdulla, J, Sivertsen, JC, Kofoed, KF, Alkadhi, H, LaBounty, T, Abildstrom, SZ, Kober, L, Christensen, E & Torp-Pedersen, C 2009, 'Evaluation of aortic valve stenosis by cardiac multislice computed tomography compared with echocardiography: a systematic review and meta-analysis', Journal of Heart Valve Disease, vol. 18, no. 6, pp. 634-43.

@article{c390a390117b11df803f000ea68e967b,

title = "Evaluation of aortic valve stenosis by cardiac multislice computed tomography compared with echocardiography: a systematic review and meta-analysis",

abstract = "BACKGROUND AND AIM OF THE STUDY: It has not yet been established whether multi-slice computed tomography (MSCT) is reliable for the quantification of aortic valve area (AVA) in patients with aortic valve stenosis (AVS) and simultaneously for assessment of the coronary anatomy. The study aim, via a systematic literature review and meta-analysis, was to explore whether MSCT is a reliable method for AVA quantification, and simultaneously to assess the coronary anatomy in patients with AVS. METHODS: A comprehensive systematic literature search and meta-analysis was conducted that included 14 studies totaling 470 patients. The meta-analysis was carried out to examine the reliability of MSCT compared to transthoracic echocardiography (TTE) and transesophageal echocardiography (TEE). Seven studies including 266 patients with AVS were also eligible for a secondary analysis to compare the accuracy of MSCT with invasive coronary angiography. RESULTS: The AVA was measured by MSCT and TTE in all 14 studies, and by TEE in four studies. The results of the meta-analyses showed that planimetry by MSCT overestimated the AVA, with a bias of 0.08 (95% CI 0.04, 0.13) cm2) (p = 0.0001) compared to TTE. The MSCT measurement was concordant with planimetry by TEE, with a small bias of -0.02 (95% CI -0.16, 0.11) cm2 (p = 0.71). MSCT, when compared to invasive angiography for the detection of significant coronary stenosis, showed sensitivity, specificity and diagnostic odds ratio of 95.5% (95% CI 88-99), 81% (95% CI 75-86)%, and 53 (95% CI 19-147), respectively. CONCLUSION: MSCT is a reliable method for the quantification of AVA, and represents a promising technique for the combined evaluation of aortic valve morphology and coronary artery disease.",

author = "Jawdat Abdulla and Jacob Sivertsen and Kofoed, {Klaus Fuglsang} and Hatem Alkadhi and Troy LaBounty and Abildstrom, {Steen Z} and K{\o}ber, {Lars Valeur} and Erik Christensen and Christian Torp-Pedersen and Jawdat Abdulla and Sivertsen, {Jacob Christian} and Kofoed, {Klaus Fuglsang} and Hatem Alkadhi and Troy LaBounty and Abildstrom, {Steen Z} and Lars Kober and Erik Christensen and Christian Torp-Pedersen",

note = "Keywords: Angiography; Aortic Valve Stenosis; Echocardiography; Humans; Tomography, X-Ray Computed",

year = "2009",

language = "English",

volume = "18",

pages = "634--43",

journal = "Journal of Heart Valve Disease",

issn = "0966-8519",

publisher = "I C R Publishers Ltd.",

number = "6",

}

TY - JOUR

T1 - Evaluation of aortic valve stenosis by cardiac multislice computed tomography compared with echocardiography: a systematic review and meta-analysis

AU - Abdulla, Jawdat

AU - Sivertsen, Jacob

AU - Kofoed, Klaus Fuglsang

AU - Alkadhi, Hatem

AU - LaBounty, Troy

AU - Abildstrom, Steen Z

AU - Køber, Lars Valeur

AU - Christensen, Erik

AU - Torp-Pedersen, Christian

AU - Abdulla, Jawdat

AU - Sivertsen, Jacob Christian

AU - Kofoed, Klaus Fuglsang

AU - Alkadhi, Hatem

AU - LaBounty, Troy

AU - Abildstrom, Steen Z

AU - Kober, Lars

AU - Christensen, Erik

AU - Torp-Pedersen, Christian

N1 - Keywords: Angiography; Aortic Valve Stenosis; Echocardiography; Humans; Tomography, X-Ray Computed

PY - 2009

Y1 - 2009

N2 - BACKGROUND AND AIM OF THE STUDY: It has not yet been established whether multi-slice computed tomography (MSCT) is reliable for the quantification of aortic valve area (AVA) in patients with aortic valve stenosis (AVS) and simultaneously for assessment of the coronary anatomy. The study aim, via a systematic literature review and meta-analysis, was to explore whether MSCT is a reliable method for AVA quantification, and simultaneously to assess the coronary anatomy in patients with AVS. METHODS: A comprehensive systematic literature search and meta-analysis was conducted that included 14 studies totaling 470 patients. The meta-analysis was carried out to examine the reliability of MSCT compared to transthoracic echocardiography (TTE) and transesophageal echocardiography (TEE). Seven studies including 266 patients with AVS were also eligible for a secondary analysis to compare the accuracy of MSCT with invasive coronary angiography. RESULTS: The AVA was measured by MSCT and TTE in all 14 studies, and by TEE in four studies. The results of the meta-analyses showed that planimetry by MSCT overestimated the AVA, with a bias of 0.08 (95% CI 0.04, 0.13) cm2) (p = 0.0001) compared to TTE. The MSCT measurement was concordant with planimetry by TEE, with a small bias of -0.02 (95% CI -0.16, 0.11) cm2 (p = 0.71). MSCT, when compared to invasive angiography for the detection of significant coronary stenosis, showed sensitivity, specificity and diagnostic odds ratio of 95.5% (95% CI 88-99), 81% (95% CI 75-86)%, and 53 (95% CI 19-147), respectively. CONCLUSION: MSCT is a reliable method for the quantification of AVA, and represents a promising technique for the combined evaluation of aortic valve morphology and coronary artery disease.

AB - BACKGROUND AND AIM OF THE STUDY: It has not yet been established whether multi-slice computed tomography (MSCT) is reliable for the quantification of aortic valve area (AVA) in patients with aortic valve stenosis (AVS) and simultaneously for assessment of the coronary anatomy. The study aim, via a systematic literature review and meta-analysis, was to explore whether MSCT is a reliable method for AVA quantification, and simultaneously to assess the coronary anatomy in patients with AVS. METHODS: A comprehensive systematic literature search and meta-analysis was conducted that included 14 studies totaling 470 patients. The meta-analysis was carried out to examine the reliability of MSCT compared to transthoracic echocardiography (TTE) and transesophageal echocardiography (TEE). Seven studies including 266 patients with AVS were also eligible for a secondary analysis to compare the accuracy of MSCT with invasive coronary angiography. RESULTS: The AVA was measured by MSCT and TTE in all 14 studies, and by TEE in four studies. The results of the meta-analyses showed that planimetry by MSCT overestimated the AVA, with a bias of 0.08 (95% CI 0.04, 0.13) cm2) (p = 0.0001) compared to TTE. The MSCT measurement was concordant with planimetry by TEE, with a small bias of -0.02 (95% CI -0.16, 0.11) cm2 (p = 0.71). MSCT, when compared to invasive angiography for the detection of significant coronary stenosis, showed sensitivity, specificity and diagnostic odds ratio of 95.5% (95% CI 88-99), 81% (95% CI 75-86)%, and 53 (95% CI 19-147), respectively. CONCLUSION: MSCT is a reliable method for the quantification of AVA, and represents a promising technique for the combined evaluation of aortic valve morphology and coronary artery disease.

M3 - Journal article

SN - 0966-8519

VL - 18

SP - 634

EP - 643

JO - Journal of Heart Valve Disease

JF - Journal of Heart Valve Disease

IS - 6

ER -

Evaluation of aortic valve stenosis by cardiac multislice computed tomography compared with echocardiography: a systematic review and meta-analysis

Abstract

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