TY - JOUR
T1 - Evaluation of a neurodevelopmental model of schizophrenia--early postnatal PCP treatment in attentional set-shifting
AU - Broberg, Brian Villumsen
AU - Dias, Rebecca
AU - Glenthøj, Birte Yding
AU - Olsen, Christina Kurre
N1 - Keywords: Age Factors; Animals; Animals, Newborn; Attention; Behavior, Animal; Discrimination (Psychology); Disease Models, Animal; Dose-Response Relationship, Drug; Evaluation Studies as Topic; Female; Male; Odors; Phencyclidine; Pregnancy; Rats; Schizophrenia; Sex Factors
PY - 2008
Y1 - 2008
N2 - Phencyclidine (PCP) was administered to male and female Lister hooded rats on postnatal days (PND) 7, 9 and 11. All PCP animals tested in adulthood (PND 53-93) showed deficits in cognitive flexibility, specifically in their ability to shift attentional set, compared to controls. This novel finding is reminiscent of the impairment observed in schizophrenia patients, and supports the validity of the early postnatal PCP regimen as a disease-like model.
AB - Phencyclidine (PCP) was administered to male and female Lister hooded rats on postnatal days (PND) 7, 9 and 11. All PCP animals tested in adulthood (PND 53-93) showed deficits in cognitive flexibility, specifically in their ability to shift attentional set, compared to controls. This novel finding is reminiscent of the impairment observed in schizophrenia patients, and supports the validity of the early postnatal PCP regimen as a disease-like model.
U2 - http://dx.doi.org/10.1016/j.bbr.2008.02.020
DO - http://dx.doi.org/10.1016/j.bbr.2008.02.020
M3 - Journal article
SN - 0166-4328
VL - 190
SP - 160
EP - 163
JO - Behavioural Brain Research
JF - Behavioural Brain Research
IS - 1
ER -