European Multicentre Tics in Children Studies (EMTICS): protocol for two cohort studies to assess risk factors for tic onset and exacerbation in children and adolescents

EMTICS Collaborative Group

doi:10.1007/s00787-018-1190-4

European Multicentre Tics in Children Studies (EMTICS): protocol for two cohort studies to assess risk factors for tic onset and exacerbation in children and adolescents

EMTICS Collaborative Group

Department of Clinical Medicine

14 Citations (Scopus)

34 Downloads (Pure)

Abstract

Genetic predisposition, autoimmunity and environmental factors [e.g. pre- and perinatal difficulties, Group A Streptococcal (GAS) and other infections, stress-inducing events] might interact to create a neurobiological vulnerability to the development of tics and associated behaviours. However, the existing evidence for this relies primarily on small prospective or larger retrospective population-based studies, and is therefore still inconclusive. This article describes the design and methodology of the EMTICS study, a longitudinal observational European multicentre study involving 16 clinical centres, with the following objectives: (1) to investigate the association of environmental factors (GAS exposure and psychosocial stress, primarily) with the onset and course of tics and/or obsessive–compulsive symptoms through the prospective observation of at-risk individuals (ONSET cohort: 260 children aged 3–10 years who are tic-free at study entry and have a first-degree relative with a chronic tic disorder) and affected individuals (COURSE cohort: 715 youth aged 3–16 years with a tic disorder); (2) to characterise the immune response to microbial antigens and the host’s immune response regulation in association with onset and exacerbations of tics; (3) to increase knowledge of the human gene pathways influencing the pathogenesis of tic disorders; and (4) to develop prediction models for the risk of onset and exacerbations of tic disorders. The EMTICS study is, to our knowledge, the largest prospective cohort assessment of the contribution of different genetic and environmental factors to the risk of developing tics in putatively predisposed individuals and to the risk of exacerbating tics in young individuals with chronic tic disorders.

Original language	English
Journal	European Child and Adolescent Psychiatry
Volume	28
Issue number	1
Pages (from-to)	91-109
Number of pages	19
ISSN	1018-8827
DOIs	https://doi.org/10.1007/s00787-018-1190-4
Publication status	Published - 2019

Keywords

Genetics
Longitudinal
Obsessive–compulsive disorder
Streptococcal infection
Stress
Tourette syndrome

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European Multicentre Tics in Children Studies (EMTICS): protocol for two cohort studies to assess risk factors for tic onset and exacerbation in children and adolescentsFinal published version, 968 KBLicence: CC BY

Cite this

@article{2c8fdbd282c34656ad1ca2c2bee321ee,

title = "European Multicentre Tics in Children Studies (EMTICS): protocol for two cohort studies to assess risk factors for tic onset and exacerbation in children and adolescents",

abstract = "Genetic predisposition, autoimmunity and environmental factors [e.g. pre- and perinatal difficulties, Group A Streptococcal (GAS) and other infections, stress-inducing events] might interact to create a neurobiological vulnerability to the development of tics and associated behaviours. However, the existing evidence for this relies primarily on small prospective or larger retrospective population-based studies, and is therefore still inconclusive. This article describes the design and methodology of the EMTICS study, a longitudinal observational European multicentre study involving 16 clinical centres, with the following objectives: (1) to investigate the association of environmental factors (GAS exposure and psychosocial stress, primarily) with the onset and course of tics and/or obsessive–compulsive symptoms through the prospective observation of at-risk individuals (ONSET cohort: 260 children aged 3–10 years who are tic-free at study entry and have a first-degree relative with a chronic tic disorder) and affected individuals (COURSE cohort: 715 youth aged 3–16 years with a tic disorder); (2) to characterise the immune response to microbial antigens and the host{\textquoteright}s immune response regulation in association with onset and exacerbations of tics; (3) to increase knowledge of the human gene pathways influencing the pathogenesis of tic disorders; and (4) to develop prediction models for the risk of onset and exacerbations of tic disorders. The EMTICS study is, to our knowledge, the largest prospective cohort assessment of the contribution of different genetic and environmental factors to the risk of developing tics in putatively predisposed individuals and to the risk of exacerbating tics in young individuals with chronic tic disorders.",

keywords = "Genetics, Longitudinal, Obsessive–compulsive disorder, Streptococcal infection, Stress, Tourette syndrome",

author = "Anette Schrag and Davide Martino and Alan Apter and Juliane Ball and Erika Bartolini and Noa Benaroya-Milshtein and Maura Buttiglione and Francesco Cardona and Roberta Creti and Androulla Efstratiou and Maria Gariup and Marianthi Georgitsi and Tammy Hedderly and Isobel Heyman and Immaculada Margarit and Pablo Mir and Natalie Moll and Astrid Morer and Norbert M{\"u}ller and Kirsten M{\"u}ller-Vahl and Alexander M{\"u}nchau and Graziella Orefici and Plessen, {Kerstin J.} and Cesare Porcelli and Peristera Paschou and Renata Rizzo and Veit Roessner and Schwarz, {Markus J.} and Tamar Steinberg and {Tagwerker Gloor}, Friederike and Zsanett Tarnok and Susanne Walitza and Andrea Dietrich and Hoekstra, {Pieter J.} and Zacharias Anastasiou and Valentina Baglioni and Benjamin Bodmer and Emese Bognar and Bianka Burger and Judith Buse and Marta Correa Vela and Debes, {Nanette M.} and Ferro, {Maria Cristina} and Carolin Fremer and Blanca Garcia-Delgar and Mariangela Gulisano and Annelieke Hagen and Julie Hagstr{\o}m and Hedderly, {Tammy J.} and Hoekstra, {Pieter J.} and {EMTICS Collaborative Group}",

year = "2019",

doi = "10.1007/s00787-018-1190-4",

language = "English",

volume = "28",

pages = "91--109",

journal = "European Child and Adolescent Psychiatry",

issn = "1018-8827",

publisher = "Springer Medizin",

number = "1",

}

TY - JOUR

T1 - European Multicentre Tics in Children Studies (EMTICS)

T2 - protocol for two cohort studies to assess risk factors for tic onset and exacerbation in children and adolescents

AU - Schrag, Anette

AU - Martino, Davide

AU - Apter, Alan

AU - Ball, Juliane

AU - Bartolini, Erika

AU - Benaroya-Milshtein, Noa

AU - Buttiglione, Maura

AU - Cardona, Francesco

AU - Creti, Roberta

AU - Efstratiou, Androulla

AU - Gariup, Maria

AU - Georgitsi, Marianthi

AU - Hedderly, Tammy

AU - Heyman, Isobel

AU - Margarit, Immaculada

AU - Mir, Pablo

AU - Moll, Natalie

AU - Morer, Astrid

AU - Müller, Norbert

AU - Müller-Vahl, Kirsten

AU - Münchau, Alexander

AU - Orefici, Graziella

AU - Plessen, Kerstin J.

AU - Porcelli, Cesare

AU - Paschou, Peristera

AU - Rizzo, Renata

AU - Roessner, Veit

AU - Schwarz, Markus J.

AU - Steinberg, Tamar

AU - Tagwerker Gloor, Friederike

AU - Tarnok, Zsanett

AU - Walitza, Susanne

AU - Dietrich, Andrea

AU - Hoekstra, Pieter J.

AU - Anastasiou, Zacharias

AU - Baglioni, Valentina

AU - Bodmer, Benjamin

AU - Bognar, Emese

AU - Burger, Bianka

AU - Buse, Judith

AU - Correa Vela, Marta

AU - Debes, Nanette M.

AU - Ferro, Maria Cristina

AU - Fremer, Carolin

AU - Garcia-Delgar, Blanca

AU - Gulisano, Mariangela

AU - Hagen, Annelieke

AU - Hagstrøm, Julie

AU - Hedderly, Tammy J.

AU - Hoekstra, Pieter J.

AU - EMTICS Collaborative Group

PY - 2019

Y1 - 2019

N2 - Genetic predisposition, autoimmunity and environmental factors [e.g. pre- and perinatal difficulties, Group A Streptococcal (GAS) and other infections, stress-inducing events] might interact to create a neurobiological vulnerability to the development of tics and associated behaviours. However, the existing evidence for this relies primarily on small prospective or larger retrospective population-based studies, and is therefore still inconclusive. This article describes the design and methodology of the EMTICS study, a longitudinal observational European multicentre study involving 16 clinical centres, with the following objectives: (1) to investigate the association of environmental factors (GAS exposure and psychosocial stress, primarily) with the onset and course of tics and/or obsessive–compulsive symptoms through the prospective observation of at-risk individuals (ONSET cohort: 260 children aged 3–10 years who are tic-free at study entry and have a first-degree relative with a chronic tic disorder) and affected individuals (COURSE cohort: 715 youth aged 3–16 years with a tic disorder); (2) to characterise the immune response to microbial antigens and the host’s immune response regulation in association with onset and exacerbations of tics; (3) to increase knowledge of the human gene pathways influencing the pathogenesis of tic disorders; and (4) to develop prediction models for the risk of onset and exacerbations of tic disorders. The EMTICS study is, to our knowledge, the largest prospective cohort assessment of the contribution of different genetic and environmental factors to the risk of developing tics in putatively predisposed individuals and to the risk of exacerbating tics in young individuals with chronic tic disorders.

AB - Genetic predisposition, autoimmunity and environmental factors [e.g. pre- and perinatal difficulties, Group A Streptococcal (GAS) and other infections, stress-inducing events] might interact to create a neurobiological vulnerability to the development of tics and associated behaviours. However, the existing evidence for this relies primarily on small prospective or larger retrospective population-based studies, and is therefore still inconclusive. This article describes the design and methodology of the EMTICS study, a longitudinal observational European multicentre study involving 16 clinical centres, with the following objectives: (1) to investigate the association of environmental factors (GAS exposure and psychosocial stress, primarily) with the onset and course of tics and/or obsessive–compulsive symptoms through the prospective observation of at-risk individuals (ONSET cohort: 260 children aged 3–10 years who are tic-free at study entry and have a first-degree relative with a chronic tic disorder) and affected individuals (COURSE cohort: 715 youth aged 3–16 years with a tic disorder); (2) to characterise the immune response to microbial antigens and the host’s immune response regulation in association with onset and exacerbations of tics; (3) to increase knowledge of the human gene pathways influencing the pathogenesis of tic disorders; and (4) to develop prediction models for the risk of onset and exacerbations of tic disorders. The EMTICS study is, to our knowledge, the largest prospective cohort assessment of the contribution of different genetic and environmental factors to the risk of developing tics in putatively predisposed individuals and to the risk of exacerbating tics in young individuals with chronic tic disorders.

KW - Genetics

KW - Longitudinal

KW - Obsessive–compulsive disorder

KW - Streptococcal infection

KW - Stress

KW - Tourette syndrome

U2 - 10.1007/s00787-018-1190-4

DO - 10.1007/s00787-018-1190-4

M3 - Journal article

C2 - 29982875

AN - SCOPUS:85049568242

SN - 1018-8827

VL - 28

SP - 91

EP - 109

JO - European Child and Adolescent Psychiatry

JF - European Child and Adolescent Psychiatry

IS - 1

ER -

European Multicentre Tics in Children Studies (EMTICS): protocol for two cohort studies to assess risk factors for tic onset and exacerbation in children and adolescents

Abstract

Keywords

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