Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling

M Givskov; R de Nys; M Manefield; L Gram; R Maximilien; Leo Eberl; Søren Molin; P D Steinberg; S Kjelleberg

Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling

M Givskov, R de Nys, M Manefield, L Gram, R Maximilien, Leo Eberl, Søren Molin, P D Steinberg, S Kjelleberg

599 Citations (Scopus)

Abstract

Acylated homoserine lactones (AHLs) play a widespread role in intercellular communication among bacteria. The Australian macroalga Delisea pulchra produces secondary metabolites which have structural similarities to AHL molecules. We report here that these metabolites inhibited AHL-controlled processes in prokaryotes. Our results suggest that the interaction between higher organisms and their surface-associated bacteria may be mediated by interference with bacterial regulatory systems.

Original language	English
Journal	Journal of Bacteriology
Volume	178
Issue number	22
Pages (from-to)	6618-22
Number of pages	5
ISSN	0021-9193
Publication status	Published - 1996
Externally published	Yes

Cite this

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title = "Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling",

abstract = "Acylated homoserine lactones (AHLs) play a widespread role in intercellular communication among bacteria. The Australian macroalga Delisea pulchra produces secondary metabolites which have structural similarities to AHL molecules. We report here that these metabolites inhibited AHL-controlled processes in prokaryotes. Our results suggest that the interaction between higher organisms and their surface-associated bacteria may be mediated by interference with bacterial regulatory systems.",

author = "M Givskov and {de Nys}, R and M Manefield and L Gram and R Maximilien and Leo Eberl and S{\o}ren Molin and Steinberg, {P D} and S Kjelleberg",

year = "1996",

language = "English",

volume = "178",

pages = "6618--22",

journal = "Journal of Bacteriology",

issn = "0021-9193",

publisher = "American Society for Microbiology",

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TY - JOUR

T1 - Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling

AU - Givskov, M

AU - de Nys, R

AU - Manefield, M

AU - Gram, L

AU - Maximilien, R

AU - Eberl, Leo

AU - Molin, Søren

AU - Steinberg, P D

AU - Kjelleberg, S

PY - 1996

Y1 - 1996

N2 - Acylated homoserine lactones (AHLs) play a widespread role in intercellular communication among bacteria. The Australian macroalga Delisea pulchra produces secondary metabolites which have structural similarities to AHL molecules. We report here that these metabolites inhibited AHL-controlled processes in prokaryotes. Our results suggest that the interaction between higher organisms and their surface-associated bacteria may be mediated by interference with bacterial regulatory systems.

AB - Acylated homoserine lactones (AHLs) play a widespread role in intercellular communication among bacteria. The Australian macroalga Delisea pulchra produces secondary metabolites which have structural similarities to AHL molecules. We report here that these metabolites inhibited AHL-controlled processes in prokaryotes. Our results suggest that the interaction between higher organisms and their surface-associated bacteria may be mediated by interference with bacterial regulatory systems.

M3 - Journal article

C2 - 8932319

SN - 0021-9193

VL - 178

SP - 6618

EP - 6622

JO - Journal of Bacteriology

JF - Journal of Bacteriology

IS - 22

ER -

Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling

Abstract

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