Ethane and n-pentane in exhaled breath are biomarkers of exposure not effect

Katrine A Gorham; Mads Peter Sulbæk Andersen; Simone Meinardi; Ralph J Delfino; Norbert Staimer; Thomas Tjoa; F Sherwood Rowland; Donald R Blake

doi:10.1080/13547500902730680

Ethane and n-pentane in exhaled breath are biomarkers of exposure not effect

Katrine A Gorham, Mads Peter Sulbæk Andersen, Simone Meinardi, Ralph J Delfino, Norbert Staimer, Thomas Tjoa, F Sherwood Rowland, Donald R Blake

Department of Chemistry

13 Citations (Scopus)

Abstract

The relationship of exhaled ethane and n-pentane to exhaled NO, carbonylated proteins, and indoor/outdoor atmospheric pollutants were examined in order to evaluate ethane and n-pentane as potential markers of airway inflammation and/or oxidative stress. Exhaled NO and carbonylated proteins were found to have no significant associations with either ethane (p = 0.96 and p = 0.81, respectively) or n-pentane (p = 0.44 and 0.28, respectively) when outliers were included. In the case where outliers were removed n-pentane was found to be inversely associated with carbonylated proteins. Exhaled hydrocarbons adjusted for indoor hydrocarbon concentrations were instead found to be positively associated with air pollutants (NO, NO(2) and CO), suggesting pollutant exposure is driving exhaled hydrocarbon concentrations. Given these findings, ethane and n-pentane do not appear to be markers of airway inflammation or oxidative stress.

Original language	English
Journal	Biomarkers
Volume	14
Issue number	1
Pages (from-to)	17-25
Number of pages	9
ISSN	1354-750X
DOIs	https://doi.org/10.1080/13547500902730680
Publication status	Published - 2009

Keywords

Aged
Aged, 80 and over
Biological Markers
Breath Tests
Ethane
Female
Humans
Male
Pentanes

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10.1080/13547500902730680

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title = "Ethane and n-pentane in exhaled breath are biomarkers of exposure not effect",

abstract = "The relationship of exhaled ethane and n-pentane to exhaled NO, carbonylated proteins, and indoor/outdoor atmospheric pollutants were examined in order to evaluate ethane and n-pentane as potential markers of airway inflammation and/or oxidative stress. Exhaled NO and carbonylated proteins were found to have no significant associations with either ethane (p = 0.96 and p = 0.81, respectively) or n-pentane (p = 0.44 and 0.28, respectively) when outliers were included. In the case where outliers were removed n-pentane was found to be inversely associated with carbonylated proteins. Exhaled hydrocarbons adjusted for indoor hydrocarbon concentrations were instead found to be positively associated with air pollutants (NO, NO(2) and CO), suggesting pollutant exposure is driving exhaled hydrocarbon concentrations. Given these findings, ethane and n-pentane do not appear to be markers of airway inflammation or oxidative stress.",

keywords = "Aged, Aged, 80 and over, Biological Markers, Breath Tests, Ethane, Female, Humans, Male, Pentanes",

author = "Gorham, {Katrine A} and Andersen, {Mads Peter Sulb{\ae}k} and Simone Meinardi and Delfino, {Ralph J} and Norbert Staimer and Thomas Tjoa and Rowland, {F Sherwood} and Blake, {Donald R}",

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T1 - Ethane and n-pentane in exhaled breath are biomarkers of exposure not effect

AU - Gorham, Katrine A

AU - Andersen, Mads Peter Sulbæk

AU - Meinardi, Simone

AU - Delfino, Ralph J

AU - Staimer, Norbert

AU - Tjoa, Thomas

AU - Rowland, F Sherwood

AU - Blake, Donald R

PY - 2009

Y1 - 2009

N2 - The relationship of exhaled ethane and n-pentane to exhaled NO, carbonylated proteins, and indoor/outdoor atmospheric pollutants were examined in order to evaluate ethane and n-pentane as potential markers of airway inflammation and/or oxidative stress. Exhaled NO and carbonylated proteins were found to have no significant associations with either ethane (p = 0.96 and p = 0.81, respectively) or n-pentane (p = 0.44 and 0.28, respectively) when outliers were included. In the case where outliers were removed n-pentane was found to be inversely associated with carbonylated proteins. Exhaled hydrocarbons adjusted for indoor hydrocarbon concentrations were instead found to be positively associated with air pollutants (NO, NO(2) and CO), suggesting pollutant exposure is driving exhaled hydrocarbon concentrations. Given these findings, ethane and n-pentane do not appear to be markers of airway inflammation or oxidative stress.

AB - The relationship of exhaled ethane and n-pentane to exhaled NO, carbonylated proteins, and indoor/outdoor atmospheric pollutants were examined in order to evaluate ethane and n-pentane as potential markers of airway inflammation and/or oxidative stress. Exhaled NO and carbonylated proteins were found to have no significant associations with either ethane (p = 0.96 and p = 0.81, respectively) or n-pentane (p = 0.44 and 0.28, respectively) when outliers were included. In the case where outliers were removed n-pentane was found to be inversely associated with carbonylated proteins. Exhaled hydrocarbons adjusted for indoor hydrocarbon concentrations were instead found to be positively associated with air pollutants (NO, NO(2) and CO), suggesting pollutant exposure is driving exhaled hydrocarbon concentrations. Given these findings, ethane and n-pentane do not appear to be markers of airway inflammation or oxidative stress.

KW - Aged

KW - Aged, 80 and over

KW - Biological Markers

KW - Breath Tests

KW - Ethane

KW - Female

KW - Humans

KW - Male

KW - Pentanes

U2 - 10.1080/13547500902730680

DO - 10.1080/13547500902730680

M3 - Journal article

C2 - 19283520

SN - 1354-750X

VL - 14

SP - 17

EP - 25

JO - Biomarkers

JF - Biomarkers

IS - 1

ER -

Ethane and n-pentane in exhaled breath are biomarkers of exposure not effect

Abstract

Keywords

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