Estimating glomerular filtration rate using the new CKD-EPI equation and other equations in patients with autosomal dominant polycystic kidney disease

Bjarne Orskov; Malene L Borresen; Bo Feldt-Rasmussen; Ole Østergaard; Inga Laursen; Svend Strandgaard; Bjarne Ørskov; Malene L Borresen; Bo Feldt-Rasmussen; Ole Østergaard; Inga Laursen; Svend Valdemar Strandgaard

doi:10.1159/000256657

Estimating glomerular filtration rate using the new CKD-EPI equation and other equations in patients with autosomal dominant polycystic kidney disease

Bjarne Orskov, Malene L Borresen, Bo Feldt-Rasmussen, Ole Østergaard, Inga Laursen, Svend Strandgaard, Bjarne Ørskov, Malene L Borresen, Bo Feldt-Rasmussen, Ole Østergaard, Inga Laursen, Svend Valdemar Strandgaard

31 Citations (Scopus)

Abstract

BACKGROUND: No studies have compared the performance of equations for estimating glomerular filtration rate (GFR) in patients with autosomal dominant polycystic kidney disease (ADPKD), where the declining GFR typically is followed for many years or even decades. This was the purpose of the present investigation. METHODS: 101 ADPKD patients with chronic kidney disease stages 1-5 were recruited and GFR was measured with the (51)Cr-EDTA clearance method, and estimated with the Modification of Diet in Renal Disease Study (MDRD) equation with 4 variables, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, the Cockcroft-Gault equation adjusted for body surface area and the MDRD equation with cystatin C. Performance was evaluated by mean bias, precision and accuracy. RESULTS: The MDRD equation with cystatin C had 97% of GFR estimates within 30% of measured GFR (accuracy). Both the CKD-EPI and Cockcroft-Gault equations had an accuracy of 90% whereas the MDRD equation had an accuracy of 83%. This difference of accuracy was especially marked with GFR >60 ml/min/1.73 m(2). CONCLUSION: For estimating GFR in ADPKD patients the MDRD equation with cystatin C incorporated had the best performance. The CKD-EPI or the Cockcroft-Gault equations showed better performance compared to the 4-variable MDRD equation.

Original language	English
Journal	American Journal of Nephrology
Volume	31
Issue number	1
Pages (from-to)	53-7
Number of pages	5
ISSN	0250-8095
DOIs	https://doi.org/10.1159/000256657
Publication status	Published - 1 Jan 2010

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Orskov, B., Borresen, M. L., Feldt-Rasmussen, B., Østergaard, O., Laursen, I., Strandgaard, S., Ørskov, B., Borresen, M. L., Feldt-Rasmussen, B., Østergaard, O., Laursen, I., & Strandgaard, S. V. (2010). Estimating glomerular filtration rate using the new CKD-EPI equation and other equations in patients with autosomal dominant polycystic kidney disease. American Journal of Nephrology, 31(1), 53-7. https://doi.org/10.1159/000256657

Estimating glomerular filtration rate using the new CKD-EPI equation and other equations in patients with autosomal dominant polycystic kidney disease. / Orskov, Bjarne; Borresen, Malene L; Feldt-Rasmussen, Bo et al.
In: American Journal of Nephrology, Vol. 31, No. 1, 01.01.2010, p. 53-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Orskov, B, Borresen, ML, Feldt-Rasmussen, B, Østergaard, O, Laursen, I, Strandgaard, S, Ørskov, B, Borresen, ML, Feldt-Rasmussen, B, Østergaard, O, Laursen, I & Strandgaard, SV 2010, 'Estimating glomerular filtration rate using the new CKD-EPI equation and other equations in patients with autosomal dominant polycystic kidney disease', American Journal of Nephrology, vol. 31, no. 1, pp. 53-7. https://doi.org/10.1159/000256657

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title = "Estimating glomerular filtration rate using the new CKD-EPI equation and other equations in patients with autosomal dominant polycystic kidney disease",

abstract = "BACKGROUND: No studies have compared the performance of equations for estimating glomerular filtration rate (GFR) in patients with autosomal dominant polycystic kidney disease (ADPKD), where the declining GFR typically is followed for many years or even decades. This was the purpose of the present investigation. METHODS: 101 ADPKD patients with chronic kidney disease stages 1-5 were recruited and GFR was measured with the (51)Cr-EDTA clearance method, and estimated with the Modification of Diet in Renal Disease Study (MDRD) equation with 4 variables, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, the Cockcroft-Gault equation adjusted for body surface area and the MDRD equation with cystatin C. Performance was evaluated by mean bias, precision and accuracy. RESULTS: The MDRD equation with cystatin C had 97% of GFR estimates within 30% of measured GFR (accuracy). Both the CKD-EPI and Cockcroft-Gault equations had an accuracy of 90% whereas the MDRD equation had an accuracy of 83%. This difference of accuracy was especially marked with GFR >60 ml/min/1.73 m(2). CONCLUSION: For estimating GFR in ADPKD patients the MDRD equation with cystatin C incorporated had the best performance. The CKD-EPI or the Cockcroft-Gault equations showed better performance compared to the 4-variable MDRD equation.",

author = "Bjarne Orskov and Borresen, {Malene L} and Bo Feldt-Rasmussen and Ole {\O}stergaard and Inga Laursen and Svend Strandgaard and Bjarne {\O}rskov and Borresen, {Malene L} and Bo Feldt-Rasmussen and Ole {\O}stergaard and Inga Laursen and Strandgaard, {Svend Valdemar}",

note = "Keywords: Adolescent; Adult; Aged; Female; Glomerular Filtration Rate; Humans; Male; Mathematics; Middle Aged; Polycystic Kidney, Autosomal Dominant; Reproducibility of Results; Young Adult",

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AU - Orskov, Bjarne

AU - Borresen, Malene L

AU - Feldt-Rasmussen, Bo

AU - Østergaard, Ole

AU - Laursen, Inga

AU - Strandgaard, Svend

AU - Ørskov, Bjarne

AU - Borresen, Malene L

AU - Feldt-Rasmussen, Bo

AU - Østergaard, Ole

AU - Laursen, Inga

AU - Strandgaard, Svend Valdemar

N1 - Keywords: Adolescent; Adult; Aged; Female; Glomerular Filtration Rate; Humans; Male; Mathematics; Middle Aged; Polycystic Kidney, Autosomal Dominant; Reproducibility of Results; Young Adult

PY - 2010/1/1

Y1 - 2010/1/1

N2 - BACKGROUND: No studies have compared the performance of equations for estimating glomerular filtration rate (GFR) in patients with autosomal dominant polycystic kidney disease (ADPKD), where the declining GFR typically is followed for many years or even decades. This was the purpose of the present investigation. METHODS: 101 ADPKD patients with chronic kidney disease stages 1-5 were recruited and GFR was measured with the (51)Cr-EDTA clearance method, and estimated with the Modification of Diet in Renal Disease Study (MDRD) equation with 4 variables, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, the Cockcroft-Gault equation adjusted for body surface area and the MDRD equation with cystatin C. Performance was evaluated by mean bias, precision and accuracy. RESULTS: The MDRD equation with cystatin C had 97% of GFR estimates within 30% of measured GFR (accuracy). Both the CKD-EPI and Cockcroft-Gault equations had an accuracy of 90% whereas the MDRD equation had an accuracy of 83%. This difference of accuracy was especially marked with GFR >60 ml/min/1.73 m(2). CONCLUSION: For estimating GFR in ADPKD patients the MDRD equation with cystatin C incorporated had the best performance. The CKD-EPI or the Cockcroft-Gault equations showed better performance compared to the 4-variable MDRD equation.

AB - BACKGROUND: No studies have compared the performance of equations for estimating glomerular filtration rate (GFR) in patients with autosomal dominant polycystic kidney disease (ADPKD), where the declining GFR typically is followed for many years or even decades. This was the purpose of the present investigation. METHODS: 101 ADPKD patients with chronic kidney disease stages 1-5 were recruited and GFR was measured with the (51)Cr-EDTA clearance method, and estimated with the Modification of Diet in Renal Disease Study (MDRD) equation with 4 variables, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, the Cockcroft-Gault equation adjusted for body surface area and the MDRD equation with cystatin C. Performance was evaluated by mean bias, precision and accuracy. RESULTS: The MDRD equation with cystatin C had 97% of GFR estimates within 30% of measured GFR (accuracy). Both the CKD-EPI and Cockcroft-Gault equations had an accuracy of 90% whereas the MDRD equation had an accuracy of 83%. This difference of accuracy was especially marked with GFR >60 ml/min/1.73 m(2). CONCLUSION: For estimating GFR in ADPKD patients the MDRD equation with cystatin C incorporated had the best performance. The CKD-EPI or the Cockcroft-Gault equations showed better performance compared to the 4-variable MDRD equation.

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JO - American Journal of Nephrology

JF - American Journal of Nephrology

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ER -

Estimating glomerular filtration rate using the new CKD-EPI equation and other equations in patients with autosomal dominant polycystic kidney disease

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