Estimating GFR in children with 99mTc-DTPA renography: a comparison with single-sample 51Cr-EDTA clearance

Henrik Gutte; Michael L Møller; Andreas K Pfeifer; Jørgen Mogens Thorup; Line Borgwardt; Lise Borgwardt; Ulrik S Kristoffersen; Andreas Kjaer

doi:10.1111/j.1475-097x.2009.00910.x

Estimating GFR in children with 99mTc-DTPA renography: a comparison with single-sample 51Cr-EDTA clearance

Henrik Gutte, Michael L Møller, Andreas K Pfeifer, Jørgen Mogens Thorup, Line Borgwardt, Lise Borgwardt, Ulrik S Kristoffersen, Andreas Kjaer

15 Citations (Scopus)

Abstract

Glomerular filtration rate (GFR) measurement by (51)Cr-ethylenediaminetetraacetic acid (EDTA) and blood sampling in children is usually cumbersome for the patient, parents and laboratory technicians. We have previously developed a method accurately estimating GFR in adults. The aim of the present study was to evaluate the accuracy of this non-invasive method in children. We calculated GFR from (99m)Tc-diethylene triamine pentaacetic acid (DTPA) renography and compared with (51)Cr-EDTA plasma clearance of 29 children between the age of 1 month and 12 years (mean 4.7 years). The correlation between (99m)Tc-DTPA renography and (51)Cr-EDTA plasma clearance was for all children R = 0.96 (n = 29, P

Original language	English
Journal	Clinical Physiology and Functional Imaging
Volume	30
Issue number	3
Pages (from-to)	169-74
Number of pages	6
ISSN	1475-0961
DOIs	https://doi.org/10.1111/j.1475-097x.2009.00910.x
Publication status	Published - 1 May 2010

Keywords

Child
Child, Preschool
Chromium Radioisotopes
Edetic Acid
Female
Glomerular Filtration Rate
Humans
Infant
Infant, Newborn
Kidney
Kidney Diseases
Male
Metabolic Clearance Rate
Radioisotope Renography
Radiopharmaceuticals
Reproducibility of Results
Sensitivity and Specificity
Technetium Tc 99m Pentetate

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title = "Estimating GFR in children with 99mTc-DTPA renography: a comparison with single-sample 51Cr-EDTA clearance",

abstract = "Glomerular filtration rate (GFR) measurement by (51)Cr-ethylenediaminetetraacetic acid (EDTA) and blood sampling in children is usually cumbersome for the patient, parents and laboratory technicians. We have previously developed a method accurately estimating GFR in adults. The aim of the present study was to evaluate the accuracy of this non-invasive method in children. We calculated GFR from (99m)Tc-diethylene triamine pentaacetic acid (DTPA) renography and compared with (51)Cr-EDTA plasma clearance of 29 children between the age of 1 month and 12 years (mean 4.7 years). The correlation between (99m)Tc-DTPA renography and (51)Cr-EDTA plasma clearance was for all children R = 0.96 (n = 29, P",

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author = "Henrik Gutte and M{\o}ller, {Michael L} and Pfeifer, {Andreas K} and Thorup, {J{\o}rgen Mogens} and Line Borgwardt and Lise Borgwardt and Kristoffersen, {Ulrik S} and Andreas Kjaer",

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AU - Gutte, Henrik

AU - Møller, Michael L

AU - Pfeifer, Andreas K

AU - Thorup, Jørgen Mogens

AU - Borgwardt, Line

AU - Borgwardt, Lise

AU - Kristoffersen, Ulrik S

AU - Kjaer, Andreas

PY - 2010/5/1

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N2 - Glomerular filtration rate (GFR) measurement by (51)Cr-ethylenediaminetetraacetic acid (EDTA) and blood sampling in children is usually cumbersome for the patient, parents and laboratory technicians. We have previously developed a method accurately estimating GFR in adults. The aim of the present study was to evaluate the accuracy of this non-invasive method in children. We calculated GFR from (99m)Tc-diethylene triamine pentaacetic acid (DTPA) renography and compared with (51)Cr-EDTA plasma clearance of 29 children between the age of 1 month and 12 years (mean 4.7 years). The correlation between (99m)Tc-DTPA renography and (51)Cr-EDTA plasma clearance was for all children R = 0.96 (n = 29, P

AB - Glomerular filtration rate (GFR) measurement by (51)Cr-ethylenediaminetetraacetic acid (EDTA) and blood sampling in children is usually cumbersome for the patient, parents and laboratory technicians. We have previously developed a method accurately estimating GFR in adults. The aim of the present study was to evaluate the accuracy of this non-invasive method in children. We calculated GFR from (99m)Tc-diethylene triamine pentaacetic acid (DTPA) renography and compared with (51)Cr-EDTA plasma clearance of 29 children between the age of 1 month and 12 years (mean 4.7 years). The correlation between (99m)Tc-DTPA renography and (51)Cr-EDTA plasma clearance was for all children R = 0.96 (n = 29, P

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KW - Edetic Acid

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KW - Infant

KW - Infant, Newborn

KW - Kidney

KW - Kidney Diseases

KW - Male

KW - Metabolic Clearance Rate

KW - Radioisotope Renography

KW - Radiopharmaceuticals

KW - Reproducibility of Results

KW - Sensitivity and Specificity

KW - Technetium Tc 99m Pentetate

U2 - 10.1111/j.1475-097x.2009.00910.x

DO - 10.1111/j.1475-097x.2009.00910.x

M3 - Journal article

C2 - 20214666

SN - 1475-0961

VL - 30

SP - 169

EP - 174

JO - Clinical Physiology and Functional Imaging

JF - Clinical Physiology and Functional Imaging

IS - 3

ER -

Estimating GFR in children with 99mTc-DTPA renography: a comparison with single-sample 51Cr-EDTA clearance

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Keywords

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