Estimates of insulin sensitivity and β-cell function in children and adolescents with and without components of the metabolic syndrome

Christine Frithioff-Bøjsøe; Cæcilie Trier; Cilius Esmann Fonvig; Anne Nissen; Julie Tonsgaard Kloppenborg; Pernille Maria Mollerup; Poul Jannik Bjerrum; Oluf Pedersen; Torben Hansen; Jens-Christian Holm

doi:10.18544/pedm-23.03.0083

Estimates of insulin sensitivity and β-cell function in children and adolescents with and without components of the metabolic syndrome

Christine Frithioff-Bøjsøe, Cæcilie Trier, Cilius Esmann Fonvig, Anne Nissen, Julie Tonsgaard Kloppenborg, Pernille Maria Mollerup, Poul Jannik Bjerrum, Oluf Pedersen, Torben Hansen, Jens-Christian Holm

1 Citation (Scopus)

Abstract

Introduction: The accumulation of components of the metabolic syndrome (MetS) is associated with a disturbed glucose metabolism in obese children. Aim of study: The aim of the present study was to evaluate the association between MetS and estimates of insulin sensitivity and β-cell function obtained from oral glucose tolerance test (OGTT)-derived indices in lean and obese children. Material and methods: A 2-hour OGTT was administered in 83 children aged 7-17 years. 47 children were obese and recruited from a childhood obesity clinic and 36 were lean age- and sex-matched controls. Surrogate measures of insulin sensitivity and β-cell function were assessed by the OGTT-derived indices: the Matsuda index, the insulinogenic index, and the oral disposition index. The severity of MetS was assessed by measures of waist circumference, blood pressure, and fasting levels of triglycerides, high-density lipoprotein cholesterol, and glucose. Results: The 83 children were allocated to one of three groups according to the number of components of MetS: the median body mass index standard deviation score was 0.2 (range -0.6-2.9) in the low MetS risk group (n=36), 2.8 (0.1-4.1) in the high MetS risk group (n=25), and 2.9 (2.1-4.4) in the MetS group (n=22). An increasing number of MetS components were associated with a lower insulin sensitivity and an altered β-cell function according to the Matsuda index (p<0.0001), the insulinogenic index (p<0.0001), and the oral disposition index (p=0.005). Conclusions: Children burdened by the accumulation of components of MetS exhibited a disturbed glucose metabolism as expressed by lowered peripheral insulin sensitivity and β-cell function.

Original language	English
Journal	Pediatric Endocrinology, Diabetes and Metabolism
Volume	23
Issue number	3
Pages (from-to)	122-129
Number of pages	8
ISSN	2081-237X
DOIs	https://doi.org/10.18544/pedm-23.03.0083
Publication status	Published - 2017

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Frithioff-Bøjsøe, C., Trier, C., Esmann Fonvig, C., Nissen, A., Kloppenborg, J. T., Mollerup, P. M., Bjerrum, P. J., Pedersen, O., Hansen, T., & Holm, J-C. (2017). Estimates of insulin sensitivity and β-cell function in children and adolescents with and without components of the metabolic syndrome. Pediatric Endocrinology, Diabetes and Metabolism, 23(3), 122-129. https://doi.org/10.18544/pedm-23.03.0083

Estimates of insulin sensitivity and β-cell function in children and adolescents with and without components of the metabolic syndrome. / Frithioff-Bøjsøe, Christine; Trier, Cæcilie; Esmann Fonvig, Cilius et al.

In: Pediatric Endocrinology, Diabetes and Metabolism, Vol. 23, No. 3, 2017, p. 122-129.

Research output: Contribution to journal › Journal article › Research › peer-review

Frithioff-Bøjsøe, C, Trier, C, Esmann Fonvig, C, Nissen, A, Kloppenborg, JT, Mollerup, PM, Bjerrum, PJ, Pedersen, O , Hansen, T & Holm, J-C 2017, 'Estimates of insulin sensitivity and β-cell function in children and adolescents with and without components of the metabolic syndrome', Pediatric Endocrinology, Diabetes and Metabolism, vol. 23, no. 3, pp. 122-129. https://doi.org/10.18544/pedm-23.03.0083

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title = "Estimates of insulin sensitivity and β-cell function in children and adolescents with and without components of the metabolic syndrome",

abstract = "Introduction: The accumulation of components of the metabolic syndrome (MetS) is associated with a disturbed glucose metabolism in obese children. Aim of study: The aim of the present study was to evaluate the association between MetS and estimates of insulin sensitivity and β-cell function obtained from oral glucose tolerance test (OGTT)-derived indices in lean and obese children. Material and methods: A 2-hour OGTT was administered in 83 children aged 7-17 years. 47 children were obese and recruited from a childhood obesity clinic and 36 were lean age- and sex-matched controls. Surrogate measures of insulin sensitivity and β-cell function were assessed by the OGTT-derived indices: the Matsuda index, the insulinogenic index, and the oral disposition index. The severity of MetS was assessed by measures of waist circumference, blood pressure, and fasting levels of triglycerides, high-density lipoprotein cholesterol, and glucose. Results: The 83 children were allocated to one of three groups according to the number of components of MetS: the median body mass index standard deviation score was 0.2 (range -0.6-2.9) in the low MetS risk group (n=36), 2.8 (0.1-4.1) in the high MetS risk group (n=25), and 2.9 (2.1-4.4) in the MetS group (n=22). An increasing number of MetS components were associated with a lower insulin sensitivity and an altered β-cell function according to the Matsuda index (p<0.0001), the insulinogenic index (p<0.0001), and the oral disposition index (p=0.005). Conclusions: Children burdened by the accumulation of components of MetS exhibited a disturbed glucose metabolism as expressed by lowered peripheral insulin sensitivity and β-cell function.",

author = "Christine Frithioff-B{\o}js{\o}e and C{\ae}cilie Trier and {Esmann Fonvig}, Cilius and Anne Nissen and Kloppenborg, {Julie Tonsgaard} and Mollerup, {Pernille Maria} and Bjerrum, {Poul Jannik} and Oluf Pedersen and Torben Hansen and Jens-Christian Holm",

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T1 - Estimates of insulin sensitivity and β-cell function in children and adolescents with and without components of the metabolic syndrome

AU - Frithioff-Bøjsøe, Christine

AU - Trier, Cæcilie

AU - Esmann Fonvig, Cilius

AU - Nissen, Anne

AU - Kloppenborg, Julie Tonsgaard

AU - Mollerup, Pernille Maria

AU - Bjerrum, Poul Jannik

AU - Pedersen, Oluf

AU - Hansen, Torben

AU - Holm, Jens-Christian

PY - 2017

Y1 - 2017

N2 - Introduction: The accumulation of components of the metabolic syndrome (MetS) is associated with a disturbed glucose metabolism in obese children. Aim of study: The aim of the present study was to evaluate the association between MetS and estimates of insulin sensitivity and β-cell function obtained from oral glucose tolerance test (OGTT)-derived indices in lean and obese children. Material and methods: A 2-hour OGTT was administered in 83 children aged 7-17 years. 47 children were obese and recruited from a childhood obesity clinic and 36 were lean age- and sex-matched controls. Surrogate measures of insulin sensitivity and β-cell function were assessed by the OGTT-derived indices: the Matsuda index, the insulinogenic index, and the oral disposition index. The severity of MetS was assessed by measures of waist circumference, blood pressure, and fasting levels of triglycerides, high-density lipoprotein cholesterol, and glucose. Results: The 83 children were allocated to one of three groups according to the number of components of MetS: the median body mass index standard deviation score was 0.2 (range -0.6-2.9) in the low MetS risk group (n=36), 2.8 (0.1-4.1) in the high MetS risk group (n=25), and 2.9 (2.1-4.4) in the MetS group (n=22). An increasing number of MetS components were associated with a lower insulin sensitivity and an altered β-cell function according to the Matsuda index (p<0.0001), the insulinogenic index (p<0.0001), and the oral disposition index (p=0.005). Conclusions: Children burdened by the accumulation of components of MetS exhibited a disturbed glucose metabolism as expressed by lowered peripheral insulin sensitivity and β-cell function.

AB - Introduction: The accumulation of components of the metabolic syndrome (MetS) is associated with a disturbed glucose metabolism in obese children. Aim of study: The aim of the present study was to evaluate the association between MetS and estimates of insulin sensitivity and β-cell function obtained from oral glucose tolerance test (OGTT)-derived indices in lean and obese children. Material and methods: A 2-hour OGTT was administered in 83 children aged 7-17 years. 47 children were obese and recruited from a childhood obesity clinic and 36 were lean age- and sex-matched controls. Surrogate measures of insulin sensitivity and β-cell function were assessed by the OGTT-derived indices: the Matsuda index, the insulinogenic index, and the oral disposition index. The severity of MetS was assessed by measures of waist circumference, blood pressure, and fasting levels of triglycerides, high-density lipoprotein cholesterol, and glucose. Results: The 83 children were allocated to one of three groups according to the number of components of MetS: the median body mass index standard deviation score was 0.2 (range -0.6-2.9) in the low MetS risk group (n=36), 2.8 (0.1-4.1) in the high MetS risk group (n=25), and 2.9 (2.1-4.4) in the MetS group (n=22). An increasing number of MetS components were associated with a lower insulin sensitivity and an altered β-cell function according to the Matsuda index (p<0.0001), the insulinogenic index (p<0.0001), and the oral disposition index (p=0.005). Conclusions: Children burdened by the accumulation of components of MetS exhibited a disturbed glucose metabolism as expressed by lowered peripheral insulin sensitivity and β-cell function.

U2 - 10.18544/pedm-23.03.0083

DO - 10.18544/pedm-23.03.0083

M3 - Journal article

C2 - 29253032

SN - 2081-237X

VL - 23

SP - 122

EP - 129

JO - Pediatric Endocrinology, Diabetes and Metabolism

JF - Pediatric Endocrinology, Diabetes and Metabolism

IS - 3

ER -

Estimates of insulin sensitivity and β-cell function in children and adolescents with and without components of the metabolic syndrome

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