Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation

Helen Shinru Wei; Hongyi Kang; Izad-Yar Daniel Rasheed; Sitong Zhou; Nanhong Lou; Anna Gershteyn; Evan Daniel McConnell; Yixuan Wang; Kristopher Emil Richardson; Andre Francis Palmer; Chris Xu; Jiandi Wan; Maiken Nedergaard

doi:10.1016/j.neuron.2016.07.016

Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation

Helen Shinru Wei, Hongyi Kang, Izad-Yar Daniel Rasheed, Sitong Zhou, Nanhong Lou, Anna Gershteyn, Evan Daniel McConnell, Yixuan Wang, Kristopher Emil Richardson, Andre Francis Palmer, Chris Xu, Jiandi Wan, Maiken Nedergaard

75 Citations (Scopus)

Abstract

Energy production in the brain depends almost exclusively on oxidative metabolism. Neurons have small energy reserves and require a continuous supply of oxygen (O2). It is therefore not surprising that one of the hallmarks of normal brain function is the tight coupling between cerebral blood flow and neuronal activity. Since capillaries are embedded in the O2-consuming neuropil, we have here examined whether activity-dependent dips in O2 tension drive capillary hyperemia. In vivo analyses showed that transient dips in tissue O2 tension elicit capillary hyperemia. Ex vivo experiments revealed that red blood cells (RBCs) themselves act as O2 sensors that autonomously regulate their own deformability and thereby flow velocity through capillaries in response to physiological decreases in O2 tension. This observation has broad implications for understanding how local changes in blood flow are coupled to synaptic transmission.

Original language	English
Journal	Neuron
Volume	91
Issue number	4
Pages (from-to)	851-862
Number of pages	12
ISSN	0896-6273
DOIs	https://doi.org/10.1016/j.neuron.2016.07.016
Publication status	Published - 17 Aug 2016

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Journal Article

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10.1016/j.neuron.2016.07.016

http://www.cell.com/article/S0896627316304019/pdf

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title = "Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation",

abstract = "Energy production in the brain depends almost exclusively on oxidative metabolism. Neurons have small energy reserves and require a continuous supply of oxygen (O2). It is therefore not surprising that one of the hallmarks of normal brain function is the tight coupling between cerebral blood flow and neuronal activity. Since capillaries are embedded in the O2-consuming neuropil, we have here examined whether activity-dependent dips in O2 tension drive capillary hyperemia. In vivo analyses showed that transient dips in tissue O2 tension elicit capillary hyperemia. Ex vivo experiments revealed that red blood cells (RBCs) themselves act as O2 sensors that autonomously regulate their own deformability and thereby flow velocity through capillaries in response to physiological decreases in O2 tension. This observation has broad implications for understanding how local changes in blood flow are coupled to synaptic transmission.",

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T1 - Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation

AU - Wei, Helen Shinru

AU - Kang, Hongyi

AU - Rasheed, Izad-Yar Daniel

AU - Zhou, Sitong

AU - Lou, Nanhong

AU - Gershteyn, Anna

AU - McConnell, Evan Daniel

AU - Wang, Yixuan

AU - Richardson, Kristopher Emil

AU - Palmer, Andre Francis

AU - Xu, Chris

AU - Wan, Jiandi

AU - Nedergaard, Maiken

PY - 2016/8/17

Y1 - 2016/8/17

N2 - Energy production in the brain depends almost exclusively on oxidative metabolism. Neurons have small energy reserves and require a continuous supply of oxygen (O2). It is therefore not surprising that one of the hallmarks of normal brain function is the tight coupling between cerebral blood flow and neuronal activity. Since capillaries are embedded in the O2-consuming neuropil, we have here examined whether activity-dependent dips in O2 tension drive capillary hyperemia. In vivo analyses showed that transient dips in tissue O2 tension elicit capillary hyperemia. Ex vivo experiments revealed that red blood cells (RBCs) themselves act as O2 sensors that autonomously regulate their own deformability and thereby flow velocity through capillaries in response to physiological decreases in O2 tension. This observation has broad implications for understanding how local changes in blood flow are coupled to synaptic transmission.

AB - Energy production in the brain depends almost exclusively on oxidative metabolism. Neurons have small energy reserves and require a continuous supply of oxygen (O2). It is therefore not surprising that one of the hallmarks of normal brain function is the tight coupling between cerebral blood flow and neuronal activity. Since capillaries are embedded in the O2-consuming neuropil, we have here examined whether activity-dependent dips in O2 tension drive capillary hyperemia. In vivo analyses showed that transient dips in tissue O2 tension elicit capillary hyperemia. Ex vivo experiments revealed that red blood cells (RBCs) themselves act as O2 sensors that autonomously regulate their own deformability and thereby flow velocity through capillaries in response to physiological decreases in O2 tension. This observation has broad implications for understanding how local changes in blood flow are coupled to synaptic transmission.

KW - Journal Article

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DO - 10.1016/j.neuron.2016.07.016

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JO - Neuron

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ER -

Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation

Abstract

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