Erosive potential of saliva stimulating tablets with and without fluoride in irradiated head and neck cancer patients

Christel Lajer; Christian Buchwald; Birgitte Nauntofte; Lena Specht; Allan Bardow; Thorbjörg Jensdottir; Christel Lajer; Christian Buchwald; Birgitte Nauntofte; Lena Specht; Allan Bardow Jensen; Thorbjörg Jensdottir

doi:10.1016/j.radonc.2009.06.028

Erosive potential of saliva stimulating tablets with and without fluoride in irradiated head and neck cancer patients

Christel Lajer, Christian Buchwald, Birgitte Nauntofte, Lena Specht, Allan Bardow, Thorbjörg Jensdottir, Christel Lajer, Christian Buchwald, Birgitte Nauntofte, Lena Specht, Allan Bardow Jensen, Thorbjörg Jensdottir

15 Citations (Scopus)

Abstract

BACKGROUND: Patients irradiated in the head and neck region often suffer from severe dry mouth and use acidic saliva stimulating products, which may cause erosion of teeth. PURPOSE: To determine saliva stimulating effects and erosive potential (EP) of acidic saliva stimulating tablets (Xerodent) with and without fluoride in irradiated head and neck cancer patients. MATERIALS AND METHOD: Nineteen irradiated patients (median age 57 years) sucked Xerodent tablets with and without fluoride. Saliva collections were divided into three 10-min sessions in the sequence: unstimulated whole saliva, Xerodent stimulated saliva without fluoride, and with fluoride. Saliva pH was determined without loss of CO(2) and in combination with inorganic measures used to calculate the degree of saturation of hydroxyapatite (HAp) and fluorapatite (FAp). EP was determined directly in all saliva samples by monitored dissolution of HAp crystals. RESULTS: Saliva flow rates increased significantly (15-fold) when sucking both tablets (p<0.001). Major changes in saliva composition caused undersaturation of HAp in some samples. However, no dissolution of HAp occurred in the saliva obtained with any of the two tablets. This was most likely due to the limited drop in pH resulting in saliva that was still supersaturated with respect to FAp. CONCLUSION: Both Xerodent with and without fluoride were evaluated as non-erosive, however, for additional caries protection the fluoride variant is preferable.

Original language	English
Journal	Radiotherapy & Oncology
Volume	93
Issue number	3
Pages (from-to)	534-8
Number of pages	5
ISSN	0167-8140
DOIs	https://doi.org/10.1016/j.radonc.2009.06.028 https://doi.org/10.1016/j.radonc.2009.06.028
Publication status	Published - 1 Dec 2009

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http://www.ncbi.nlm.nih.gov/pubmed/?term=Erosive+potential+of+saliva+stimulating+tablets+with+and+without+fluoride+in+irradiated+head+and+neck+cancer+patients

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Lajer, C., Buchwald, C., Nauntofte, B., Specht, L., Bardow, A., Jensdottir, T., Lajer, C., Buchwald, C., Nauntofte, B., Specht, L., Jensen, A. B., & Jensdottir, T. (2009). Erosive potential of saliva stimulating tablets with and without fluoride in irradiated head and neck cancer patients. Radiotherapy & Oncology, 93(3), 534-8. https://doi.org/10.1016/j.radonc.2009.06.028, https://doi.org/10.1016/j.radonc.2009.06.028

Lajer, C, Buchwald, C, Nauntofte, B, Specht, L, Bardow, A, Jensdottir, T, Lajer, C, Buchwald, C, Nauntofte, B, Specht, L, Jensen, AB & Jensdottir, T 2009, 'Erosive potential of saliva stimulating tablets with and without fluoride in irradiated head and neck cancer patients', Radiotherapy & Oncology, vol. 93, no. 3, pp. 534-8. https://doi.org/10.1016/j.radonc.2009.06.028, https://doi.org/10.1016/j.radonc.2009.06.028

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title = "Erosive potential of saliva stimulating tablets with and without fluoride in irradiated head and neck cancer patients",

abstract = "BACKGROUND: Patients irradiated in the head and neck region often suffer from severe dry mouth and use acidic saliva stimulating products, which may cause erosion of teeth. PURPOSE: To determine saliva stimulating effects and erosive potential (EP) of acidic saliva stimulating tablets (Xerodent) with and without fluoride in irradiated head and neck cancer patients. MATERIALS AND METHOD: Nineteen irradiated patients (median age 57 years) sucked Xerodent tablets with and without fluoride. Saliva collections were divided into three 10-min sessions in the sequence: unstimulated whole saliva, Xerodent stimulated saliva without fluoride, and with fluoride. Saliva pH was determined without loss of CO(2) and in combination with inorganic measures used to calculate the degree of saturation of hydroxyapatite (HAp) and fluorapatite (FAp). EP was determined directly in all saliva samples by monitored dissolution of HAp crystals. RESULTS: Saliva flow rates increased significantly (15-fold) when sucking both tablets (p<0.001). Major changes in saliva composition caused undersaturation of HAp in some samples. However, no dissolution of HAp occurred in the saliva obtained with any of the two tablets. This was most likely due to the limited drop in pH resulting in saliva that was still supersaturated with respect to FAp. CONCLUSION: Both Xerodent with and without fluoride were evaluated as non-erosive, however, for additional caries protection the fluoride variant is preferable.",

author = "Christel Lajer and Christian Buchwald and Birgitte Nauntofte and Lena Specht and Allan Bardow and Thorbj{\"o}rg Jensdottir and Christel Lajer and Christian Buchwald and Birgitte Nauntofte and Lena Specht and Jensen, {Allan Bardow} and Thorbj{\"o}rg Jensdottir",

note = "Keywords: Apatites; Dental Caries; Durapatite; Female; Fluorides; Head and Neck Neoplasms; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Radioactive Hazard Release; Saliva; Salivary Glands; Tooth Erosion; Xerostomia",

year = "2009",

month = dec,

day = "1",

doi = "10.1016/j.radonc.2009.06.028",

language = "English",

volume = "93",

pages = "534--8",

journal = "Radiotherapy & Oncology",

issn = "0167-8140",

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TY - JOUR

T1 - Erosive potential of saliva stimulating tablets with and without fluoride in irradiated head and neck cancer patients

AU - Lajer, Christel

AU - Buchwald, Christian

AU - Nauntofte, Birgitte

AU - Specht, Lena

AU - Bardow, Allan

AU - Jensdottir, Thorbjörg

AU - Lajer, Christel

AU - Buchwald, Christian

AU - Nauntofte, Birgitte

AU - Specht, Lena

AU - Jensen, Allan Bardow

AU - Jensdottir, Thorbjörg

N1 - Keywords: Apatites; Dental Caries; Durapatite; Female; Fluorides; Head and Neck Neoplasms; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Radioactive Hazard Release; Saliva; Salivary Glands; Tooth Erosion; Xerostomia

PY - 2009/12/1

Y1 - 2009/12/1

N2 - BACKGROUND: Patients irradiated in the head and neck region often suffer from severe dry mouth and use acidic saliva stimulating products, which may cause erosion of teeth. PURPOSE: To determine saliva stimulating effects and erosive potential (EP) of acidic saliva stimulating tablets (Xerodent) with and without fluoride in irradiated head and neck cancer patients. MATERIALS AND METHOD: Nineteen irradiated patients (median age 57 years) sucked Xerodent tablets with and without fluoride. Saliva collections were divided into three 10-min sessions in the sequence: unstimulated whole saliva, Xerodent stimulated saliva without fluoride, and with fluoride. Saliva pH was determined without loss of CO(2) and in combination with inorganic measures used to calculate the degree of saturation of hydroxyapatite (HAp) and fluorapatite (FAp). EP was determined directly in all saliva samples by monitored dissolution of HAp crystals. RESULTS: Saliva flow rates increased significantly (15-fold) when sucking both tablets (p<0.001). Major changes in saliva composition caused undersaturation of HAp in some samples. However, no dissolution of HAp occurred in the saliva obtained with any of the two tablets. This was most likely due to the limited drop in pH resulting in saliva that was still supersaturated with respect to FAp. CONCLUSION: Both Xerodent with and without fluoride were evaluated as non-erosive, however, for additional caries protection the fluoride variant is preferable.

AB - BACKGROUND: Patients irradiated in the head and neck region often suffer from severe dry mouth and use acidic saliva stimulating products, which may cause erosion of teeth. PURPOSE: To determine saliva stimulating effects and erosive potential (EP) of acidic saliva stimulating tablets (Xerodent) with and without fluoride in irradiated head and neck cancer patients. MATERIALS AND METHOD: Nineteen irradiated patients (median age 57 years) sucked Xerodent tablets with and without fluoride. Saliva collections were divided into three 10-min sessions in the sequence: unstimulated whole saliva, Xerodent stimulated saliva without fluoride, and with fluoride. Saliva pH was determined without loss of CO(2) and in combination with inorganic measures used to calculate the degree of saturation of hydroxyapatite (HAp) and fluorapatite (FAp). EP was determined directly in all saliva samples by monitored dissolution of HAp crystals. RESULTS: Saliva flow rates increased significantly (15-fold) when sucking both tablets (p<0.001). Major changes in saliva composition caused undersaturation of HAp in some samples. However, no dissolution of HAp occurred in the saliva obtained with any of the two tablets. This was most likely due to the limited drop in pH resulting in saliva that was still supersaturated with respect to FAp. CONCLUSION: Both Xerodent with and without fluoride were evaluated as non-erosive, however, for additional caries protection the fluoride variant is preferable.

U2 - 10.1016/j.radonc.2009.06.028

DO - 10.1016/j.radonc.2009.06.028

M3 - Journal article

C2 - 19619910

SN - 0167-8140

VL - 93

SP - 534

EP - 538

JO - Radiotherapy & Oncology

JF - Radiotherapy & Oncology

IS - 3

ER -

Erosive potential of saliva stimulating tablets with and without fluoride in irradiated head and neck cancer patients

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