Epigenetisk påvirkning af fosterets udvikling

Ida Donkin; Romain Barrès; Anja Pinborg

Epigenetisk påvirkning af fosterets udvikling

Translated title of the contribution: Epigenetic influence on embryonic development

Department of Clinical Medicine

Abstract

The epigenome is sensitive to environmental changes and can sustainably alter gene expression, notably during embryonic development. New research indicates that epigenetic factors are heritable, which is why paternal lifestyle may affect fetal development and risk of disease. Children conceived by assisted reproduction technology (ART) have an increased risk of peri- and postnatal complications, and as specific ART protocols associate with specific risk profiles, the procedures themselves may cause epigenetic changes contributing to the altered outcomes of the 5,000 Danish children annually conceived by ART.

Translated title of the contribution	Epigenetic influence on embryonic development
Original language	Danish
Article number	V02160132
Journal	Ugeskrift for Laeger
Volume	178
Issue number	37
Pages (from-to)	2-5
ISSN	0041-5782
Publication status	Published - 12 Sept 2016

Keywords

English Abstract
Journal Article

Access to Document

http://ugeskriftet.dk/videnskab/epigenetisk-paavirkning-af-fosterets-udvikling

Cite this

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AU - Donkin, Ida

AU - Barrès, Romain

AU - Pinborg, Anja

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N2 - The epigenome is sensitive to environmental changes and can sustainably alter gene expression, notably during embryonic development. New research indicates that epigenetic factors are heritable, which is why paternal lifestyle may affect fetal development and risk of disease. Children conceived by assisted reproduction technology (ART) have an increased risk of peri- and postnatal complications, and as specific ART protocols associate with specific risk profiles, the procedures themselves may cause epigenetic changes contributing to the altered outcomes of the 5,000 Danish children annually conceived by ART.

AB - The epigenome is sensitive to environmental changes and can sustainably alter gene expression, notably during embryonic development. New research indicates that epigenetic factors are heritable, which is why paternal lifestyle may affect fetal development and risk of disease. Children conceived by assisted reproduction technology (ART) have an increased risk of peri- and postnatal complications, and as specific ART protocols associate with specific risk profiles, the procedures themselves may cause epigenetic changes contributing to the altered outcomes of the 5,000 Danish children annually conceived by ART.

KW - English Abstract

KW - Journal Article

M3 - Tidsskriftartikel

C2 - 27649584

SN - 0041-5782

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IS - 37

M1 - V02160132

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Epigenetisk påvirkning af fosterets udvikling

Abstract

Keywords

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