Environmental factors in a population-based inception cohort of inflammatory bowel disease patients in Europe: An ECCO-EpiCom study

J Burisch; Natalia Pedersen; S Cukovic-Cavka; N Turk; I Kaimakliotis; D Duricova; M Bortlik; O Shonová; Ida Vind; S Avnstrøm; N Thorsgaard; S Krabbe; V Andersen; J F Dahlerup; J Kjeldsen; R Salupere; J Olsen; K R Nielsen; P Manninen; P Collin; K H Katsanos; E V Tsianos; K Ladefoged; L Lakatos; G Ragnarsson; E Björnsson; Y Bailey; C O'Morain; D Schwartz; S Odes; M Giannotta; G Girardin; G Kiudelis; L Kupcinskas; S Turcan; L Barros; F Magro; D Lazar; A Goldis; I Nikulina; E Belousova; D Martinez-Ares; V Hernandez; S Almer; Y Zhulina; J Halfvarson; N Arebi; H H Tsai; E Langholz; P Munkholm; EpiCom Group

doi:10.1016/j.crohns.2013.11.021

Environmental factors in a population-based inception cohort of inflammatory bowel disease patients in Europe: An ECCO-EpiCom study

J Burisch, Natalia Pedersen, S Cukovic-Cavka, N Turk, I Kaimakliotis, D Duricova, M Bortlik, O Shonová, Ida Vind, S Avnstrøm, N Thorsgaard, S Krabbe, V Andersen, J F Dahlerup, J Kjeldsen, R Salupere, J Olsen, K R Nielsen, P Manninen, P CollinK H Katsanos, E V Tsianos, K Ladefoged, L Lakatos, G Ragnarsson, E Björnsson, Y Bailey, C O'Morain, D Schwartz, S Odes, M Giannotta, G Girardin, G Kiudelis, L Kupcinskas, S Turcan, L Barros, F Magro, D Lazar, A Goldis, I Nikulina, E Belousova, D Martinez-Ares, V Hernandez, S Almer, Y Zhulina, J Halfvarson, N Arebi, H H Tsai, E Langholz, P Munkholm, EpiCom Group

Department of Clinical Medicine

52 Citations (Scopus)

Abstract

Background and Aims: The incidence of inflammatory bowel disease (IBD) is increasing in Eastern Europe possibly due to changes in environmental factors towards a more "westernised" standard of living. The aim of this study was to investigate differences in exposure to environmental factors prior to diagnosis in Eastern and Western European IBD patients. Methods: The EpiCom cohort is a population-based, prospective inception cohort of 1560 unselected IBD patients from 31 European countries covering a background population of 10.1. million. At the time of diagnosis patients were asked to complete an 87-item questionnaire concerning environmental factors. Results: A total of 1182 patients (76%) answered the questionnaire, 444 (38%) had Crohn's disease (CD), 627 (53%) ulcerative colitis (UC), and 111 (9%) IBD unclassified. No geographic differences regarding smoking status, caffeine intake, use of oral contraceptives, or number of first-degree relatives with IBD were found. Sugar intake was higher in CD and UC patients from Eastern Europe than in Western Europe while fibre intake was lower (p. <. 0.01). Daily consumption of fast food as well as appendectomy before the age of 20 was more frequent in Eastern European than in Western European UC patients (p. <. 0.01). Eastern European CD and UC patients had received more vaccinations and experienced fewer childhood infections than Western European patients (p. <. 0.01). Conclusions: In this European population-based inception cohort of unselected IBD patients, Eastern and Western European patients differed in environmental factors prior to diagnosis. Eastern European patients exhibited higher occurrences of suspected risk factors for IBD included in the Western lifestyle.

Original language	English
Journal	Journal of Crohn's & colitis
Volume	8
Issue number	7
Pages (from-to)	607-16
Number of pages	10
ISSN	1873-9946
DOIs	https://doi.org/10.1016/j.crohns.2013.11.021
Publication status	Published - 1 Jul 2014

Keywords

Adolescent
Adult
Aged
Aged, 80 and over
Appendectomy
Colitis, Ulcerative
Crohn Disease
Dietary Fiber
Dietary Sucrose
Europe
Fast Foods
Female
Hospitalization
Humans
Male
Measles
Middle Aged
Mumps
Prospective Studies
Questionnaires
Risk Factors
Severity of Illness Index
Vaccination
Whooping Cough
Young Adult

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.crohns.2013.11.021

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Burisch, J., Pedersen, N., Cukovic-Cavka, S., Turk, N., Kaimakliotis, I., Duricova, D., Bortlik, M., Shonová, O., Vind, I., Avnstrøm, S., Thorsgaard, N., Krabbe, S., Andersen, V., Dahlerup, J. F., Kjeldsen, J., Salupere, R., Olsen, J., Nielsen, K. R., Manninen, P., ... EpiCom Group (2014). Environmental factors in a population-based inception cohort of inflammatory bowel disease patients in Europe: An ECCO-EpiCom study . Journal of Crohn's & colitis, 8(7), 607-16. https://doi.org/10.1016/j.crohns.2013.11.021

Burisch, J, Pedersen, N, Cukovic-Cavka, S, Turk, N, Kaimakliotis, I, Duricova, D, Bortlik, M, Shonová, O, Vind, I, Avnstrøm, S, Thorsgaard, N, Krabbe, S, Andersen, V, Dahlerup, JF, Kjeldsen, J, Salupere, R, Olsen, J, Nielsen, KR, Manninen, P, Collin, P, Katsanos, KH, Tsianos, EV, Ladefoged, K, Lakatos, L, Ragnarsson, G, Björnsson, E, Bailey, Y, O'Morain, C, Schwartz, D, Odes, S, Giannotta, M, Girardin, G, Kiudelis, G, Kupcinskas, L, Turcan, S, Barros, L, Magro, F, Lazar, D, Goldis, A, Nikulina, I, Belousova, E, Martinez-Ares, D, Hernandez, V, Almer, S, Zhulina, Y, Halfvarson, J, Arebi, N, Tsai, HH, Langholz, E , Munkholm, P & EpiCom Group 2014, 'Environmental factors in a population-based inception cohort of inflammatory bowel disease patients in Europe: An ECCO-EpiCom study ', Journal of Crohn's & colitis, vol. 8, no. 7, pp. 607-16. https://doi.org/10.1016/j.crohns.2013.11.021

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title = "Environmental factors in a population-based inception cohort of inflammatory bowel disease patients in Europe: An ECCO-EpiCom study ",

abstract = "Background and Aims: The incidence of inflammatory bowel disease (IBD) is increasing in Eastern Europe possibly due to changes in environmental factors towards a more {"}westernised{"} standard of living. The aim of this study was to investigate differences in exposure to environmental factors prior to diagnosis in Eastern and Western European IBD patients. Methods: The EpiCom cohort is a population-based, prospective inception cohort of 1560 unselected IBD patients from 31 European countries covering a background population of 10.1. million. At the time of diagnosis patients were asked to complete an 87-item questionnaire concerning environmental factors. Results: A total of 1182 patients (76%) answered the questionnaire, 444 (38%) had Crohn's disease (CD), 627 (53%) ulcerative colitis (UC), and 111 (9%) IBD unclassified. No geographic differences regarding smoking status, caffeine intake, use of oral contraceptives, or number of first-degree relatives with IBD were found. Sugar intake was higher in CD and UC patients from Eastern Europe than in Western Europe while fibre intake was lower (p. <. 0.01). Daily consumption of fast food as well as appendectomy before the age of 20 was more frequent in Eastern European than in Western European UC patients (p. <. 0.01). Eastern European CD and UC patients had received more vaccinations and experienced fewer childhood infections than Western European patients (p. <. 0.01). Conclusions: In this European population-based inception cohort of unselected IBD patients, Eastern and Western European patients differed in environmental factors prior to diagnosis. Eastern European patients exhibited higher occurrences of suspected risk factors for IBD included in the Western lifestyle.",

keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Appendectomy, Colitis, Ulcerative, Crohn Disease, Dietary Fiber, Dietary Sucrose, Europe, Fast Foods, Female, Hospitalization, Humans, Male, Measles, Middle Aged, Mumps, Prospective Studies, Questionnaires, Risk Factors, Severity of Illness Index, Vaccination, Whooping Cough, Young Adult",

author = "J Burisch and Natalia Pedersen and S Cukovic-Cavka and N Turk and I Kaimakliotis and D Duricova and M Bortlik and O Shonov{\'a} and Ida Vind and S Avnstr{\o}m and N Thorsgaard and S Krabbe and V Andersen and Dahlerup, {J F} and J Kjeldsen and R Salupere and J Olsen and Nielsen, {K R} and P Manninen and P Collin and Katsanos, {K H} and Tsianos, {E V} and K Ladefoged and L Lakatos and G Ragnarsson and E Bj{\"o}rnsson and Y Bailey and C O'Morain and D Schwartz and S Odes and M Giannotta and G Girardin and G Kiudelis and L Kupcinskas and S Turcan and L Barros and F Magro and D Lazar and A Goldis and I Nikulina and E Belousova and D Martinez-Ares and V Hernandez and S Almer and Y Zhulina and J Halfvarson and N Arebi and Tsai, {H H} and E Langholz and P Munkholm and {EpiCom Group}",

year = "2014",

month = jul,

day = "1",

doi = "10.1016/j.crohns.2013.11.021",

language = "English",

volume = "8",

pages = "607--16",

journal = "Journal of Crohn's and Colitis",

issn = "1873-9946",

publisher = "Oxford University Press",

number = "7",

}

TY - JOUR

T1 - Environmental factors in a population-based inception cohort of inflammatory bowel disease patients in Europe

T2 - An ECCO-EpiCom study

AU - Burisch, J

AU - Pedersen, Natalia

AU - Cukovic-Cavka, S

AU - Turk, N

AU - Kaimakliotis, I

AU - Duricova, D

AU - Bortlik, M

AU - Shonová, O

AU - Vind, Ida

AU - Avnstrøm, S

AU - Thorsgaard, N

AU - Krabbe, S

AU - Andersen, V

AU - Dahlerup, J F

AU - Kjeldsen, J

AU - Salupere, R

AU - Olsen, J

AU - Nielsen, K R

AU - Manninen, P

AU - Collin, P

AU - Katsanos, K H

AU - Tsianos, E V

AU - Ladefoged, K

AU - Lakatos, L

AU - Ragnarsson, G

AU - Björnsson, E

AU - Bailey, Y

AU - O'Morain, C

AU - Schwartz, D

AU - Odes, S

AU - Giannotta, M

AU - Girardin, G

AU - Kiudelis, G

AU - Kupcinskas, L

AU - Turcan, S

AU - Barros, L

AU - Magro, F

AU - Lazar, D

AU - Goldis, A

AU - Nikulina, I

AU - Belousova, E

AU - Martinez-Ares, D

AU - Hernandez, V

AU - Almer, S

AU - Zhulina, Y

AU - Halfvarson, J

AU - Arebi, N

AU - Tsai, H H

AU - Langholz, E

AU - Munkholm, P

AU - EpiCom Group

PY - 2014/7/1

Y1 - 2014/7/1

N2 - Background and Aims: The incidence of inflammatory bowel disease (IBD) is increasing in Eastern Europe possibly due to changes in environmental factors towards a more "westernised" standard of living. The aim of this study was to investigate differences in exposure to environmental factors prior to diagnosis in Eastern and Western European IBD patients. Methods: The EpiCom cohort is a population-based, prospective inception cohort of 1560 unselected IBD patients from 31 European countries covering a background population of 10.1. million. At the time of diagnosis patients were asked to complete an 87-item questionnaire concerning environmental factors. Results: A total of 1182 patients (76%) answered the questionnaire, 444 (38%) had Crohn's disease (CD), 627 (53%) ulcerative colitis (UC), and 111 (9%) IBD unclassified. No geographic differences regarding smoking status, caffeine intake, use of oral contraceptives, or number of first-degree relatives with IBD were found. Sugar intake was higher in CD and UC patients from Eastern Europe than in Western Europe while fibre intake was lower (p. <. 0.01). Daily consumption of fast food as well as appendectomy before the age of 20 was more frequent in Eastern European than in Western European UC patients (p. <. 0.01). Eastern European CD and UC patients had received more vaccinations and experienced fewer childhood infections than Western European patients (p. <. 0.01). Conclusions: In this European population-based inception cohort of unselected IBD patients, Eastern and Western European patients differed in environmental factors prior to diagnosis. Eastern European patients exhibited higher occurrences of suspected risk factors for IBD included in the Western lifestyle.

AB - Background and Aims: The incidence of inflammatory bowel disease (IBD) is increasing in Eastern Europe possibly due to changes in environmental factors towards a more "westernised" standard of living. The aim of this study was to investigate differences in exposure to environmental factors prior to diagnosis in Eastern and Western European IBD patients. Methods: The EpiCom cohort is a population-based, prospective inception cohort of 1560 unselected IBD patients from 31 European countries covering a background population of 10.1. million. At the time of diagnosis patients were asked to complete an 87-item questionnaire concerning environmental factors. Results: A total of 1182 patients (76%) answered the questionnaire, 444 (38%) had Crohn's disease (CD), 627 (53%) ulcerative colitis (UC), and 111 (9%) IBD unclassified. No geographic differences regarding smoking status, caffeine intake, use of oral contraceptives, or number of first-degree relatives with IBD were found. Sugar intake was higher in CD and UC patients from Eastern Europe than in Western Europe while fibre intake was lower (p. <. 0.01). Daily consumption of fast food as well as appendectomy before the age of 20 was more frequent in Eastern European than in Western European UC patients (p. <. 0.01). Eastern European CD and UC patients had received more vaccinations and experienced fewer childhood infections than Western European patients (p. <. 0.01). Conclusions: In this European population-based inception cohort of unselected IBD patients, Eastern and Western European patients differed in environmental factors prior to diagnosis. Eastern European patients exhibited higher occurrences of suspected risk factors for IBD included in the Western lifestyle.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Appendectomy

KW - Colitis, Ulcerative

KW - Crohn Disease

KW - Dietary Fiber

KW - Dietary Sucrose

KW - Europe

KW - Fast Foods

KW - Female

KW - Hospitalization

KW - Humans

KW - Male

KW - Measles

KW - Middle Aged

KW - Mumps

KW - Prospective Studies

KW - Questionnaires

KW - Risk Factors

KW - Severity of Illness Index

KW - Vaccination

KW - Whooping Cough

KW - Young Adult

U2 - 10.1016/j.crohns.2013.11.021

DO - 10.1016/j.crohns.2013.11.021

M3 - Journal article

C2 - 24315795

SN - 1873-9946

VL - 8

SP - 607

EP - 616

JO - Journal of Crohn's and Colitis

JF - Journal of Crohn's and Colitis

IS - 7

ER -

Environmental factors in a population-based inception cohort of inflammatory bowel disease patients in Europe: An ECCO-EpiCom study

Abstract

Keywords

UN SDGs

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