Energy metabolism during repeated sets of leg press exercise leading to failure or not

Esteban M Gorostiaga; Ion Navarro-Amézqueta; José A L Calbet; Ylva Hellsten; Roser Cusso; Mario Guerrero; Cristina Granados; Miriam González-Izal; Javier Ibañez; Mikel Izquierdo

doi:10.1371/annotation/ca21efee-84a1-4031-9dcd-224af64b7753

Energy metabolism during repeated sets of leg press exercise leading to failure or not

Esteban M Gorostiaga, Ion Navarro-Amézqueta, José A L Calbet, Ylva Hellsten, Roser Cusso, Mario Guerrero, Cristina Granados, Miriam González-Izal, Javier Ibañez, Mikel Izquierdo

72 Citations (Scopus)

Abstract

This investigation examined the influence of the number of repetitions per set on power output and muscle metabolism during leg press exercise. Six trained men (age 34±6 yr) randomly performed either 5 sets of 10 repetitions (10REP), or 10 sets of 5 repetitions (5REP) of bilateral leg press exercise, with the same initial load and rest intervals between sets. Muscle biopsies (vastus lateralis) were taken before the first set, and after the first and the final sets. Compared with 5REP, 10REP resulted in a markedly greater decrease (P<0.05) of the power output, muscle PCr and ATP content, and markedly higher (P<0.05) levels of muscle lactate and IMP. Significant correlations (P<0.01) were observed between changes in muscle PCr and muscle lactate (R² = 0.46), between changes in muscle PCr and IMP (R² = 0.44) as well as between changes in power output and changes in muscle ATP (R² = 0.59) and lactate (R² = 0.64) levels. Reducing the number of repetitions per set by 50% causes a lower disruption to the energy balance in the muscle. The correlations suggest that the changes in PCr and muscle lactate mainly occur simultaneously during exercise, whereas IMP only accumulates when PCr levels are low. The decrease in ATP stores may contribute to fatigue.

Original language	English
Article number	e40621
Journal	P L o S One
Volume	7
Issue number	7
Number of pages	9
ISSN	1932-6203
DOIs	https://doi.org/10.1371/annotation/ca21efee-84a1-4031-9dcd-224af64b7753 https://doi.org/10.1371/journal.pone.0040621
Publication status	Published - 13 Jul 2012

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Gorostiaga, E. M., Navarro-Amézqueta, I., Calbet, J. A. L., Hellsten, Y., Cusso, R., Guerrero, M., Granados, C., González-Izal, M., Ibañez, J., & Izquierdo, M. (2012). Energy metabolism during repeated sets of leg press exercise leading to failure or not. P L o S One, 7(7), [e40621]. https://doi.org/10.1371/annotation/ca21efee-84a1-4031-9dcd-224af64b7753, https://doi.org/10.1371/journal.pone.0040621

Gorostiaga, EM, Navarro-Amézqueta, I, Calbet, JAL, Hellsten, Y, Cusso, R, Guerrero, M, Granados, C, González-Izal, M, Ibañez, J & Izquierdo, M 2012, 'Energy metabolism during repeated sets of leg press exercise leading to failure or not', P L o S One, vol. 7, no. 7, e40621. https://doi.org/10.1371/annotation/ca21efee-84a1-4031-9dcd-224af64b7753, https://doi.org/10.1371/journal.pone.0040621

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abstract = "This investigation examined the influence of the number of repetitions per set on power output and muscle metabolism during leg press exercise. Six trained men (age 34±6 yr) randomly performed either 5 sets of 10 repetitions (10REP), or 10 sets of 5 repetitions (5REP) of bilateral leg press exercise, with the same initial load and rest intervals between sets. Muscle biopsies (vastus lateralis) were taken before the first set, and after the first and the final sets. Compared with 5REP, 10REP resulted in a markedly greater decrease (P<0.05) of the power output, muscle PCr and ATP content, and markedly higher (P<0.05) levels of muscle lactate and IMP. Significant correlations (P<0.01) were observed between changes in muscle PCr and muscle lactate (R2 = 0.46), between changes in muscle PCr and IMP (R2 = 0.44) as well as between changes in power output and changes in muscle ATP (R2 = 0.59) and lactate (R2 = 0.64) levels. Reducing the number of repetitions per set by 50% causes a lower disruption to the energy balance in the muscle. The correlations suggest that the changes in PCr and muscle lactate mainly occur simultaneously during exercise, whereas IMP only accumulates when PCr levels are low. The decrease in ATP stores may contribute to fatigue.",

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AU - Gorostiaga, Esteban M

AU - Navarro-Amézqueta, Ion

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AU - Hellsten, Ylva

AU - Cusso, Roser

AU - Guerrero, Mario

AU - Granados, Cristina

AU - González-Izal, Miriam

AU - Ibañez, Javier

AU - Izquierdo, Mikel

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N2 - This investigation examined the influence of the number of repetitions per set on power output and muscle metabolism during leg press exercise. Six trained men (age 34±6 yr) randomly performed either 5 sets of 10 repetitions (10REP), or 10 sets of 5 repetitions (5REP) of bilateral leg press exercise, with the same initial load and rest intervals between sets. Muscle biopsies (vastus lateralis) were taken before the first set, and after the first and the final sets. Compared with 5REP, 10REP resulted in a markedly greater decrease (P<0.05) of the power output, muscle PCr and ATP content, and markedly higher (P<0.05) levels of muscle lactate and IMP. Significant correlations (P<0.01) were observed between changes in muscle PCr and muscle lactate (R2 = 0.46), between changes in muscle PCr and IMP (R2 = 0.44) as well as between changes in power output and changes in muscle ATP (R2 = 0.59) and lactate (R2 = 0.64) levels. Reducing the number of repetitions per set by 50% causes a lower disruption to the energy balance in the muscle. The correlations suggest that the changes in PCr and muscle lactate mainly occur simultaneously during exercise, whereas IMP only accumulates when PCr levels are low. The decrease in ATP stores may contribute to fatigue.

AB - This investigation examined the influence of the number of repetitions per set on power output and muscle metabolism during leg press exercise. Six trained men (age 34±6 yr) randomly performed either 5 sets of 10 repetitions (10REP), or 10 sets of 5 repetitions (5REP) of bilateral leg press exercise, with the same initial load and rest intervals between sets. Muscle biopsies (vastus lateralis) were taken before the first set, and after the first and the final sets. Compared with 5REP, 10REP resulted in a markedly greater decrease (P<0.05) of the power output, muscle PCr and ATP content, and markedly higher (P<0.05) levels of muscle lactate and IMP. Significant correlations (P<0.01) were observed between changes in muscle PCr and muscle lactate (R2 = 0.46), between changes in muscle PCr and IMP (R2 = 0.44) as well as between changes in power output and changes in muscle ATP (R2 = 0.59) and lactate (R2 = 0.64) levels. Reducing the number of repetitions per set by 50% causes a lower disruption to the energy balance in the muscle. The correlations suggest that the changes in PCr and muscle lactate mainly occur simultaneously during exercise, whereas IMP only accumulates when PCr levels are low. The decrease in ATP stores may contribute to fatigue.

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Energy metabolism during repeated sets of leg press exercise leading to failure or not

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