Endocrine mechanisms and assay issues in premature progesterone elevation in assisted reproductive technology

Dominique de Ziegler; Claus Yding Andersen; Frank Z. Stanczyk; Jean Marc Ayoubi

doi:10.1016/j.fertnstert.2018.02.137

Endocrine mechanisms and assay issues in premature progesterone elevation in assisted reproductive technology

Dominique de Ziegler^*, Claus Yding Andersen, Frank Z. Stanczyk, Jean Marc Ayoubi

^*Corresponding author for this work

Department of Clinical Medicine

5 Citations (Scopus)

Abstract

Progesterone elevation occurring in the late phases of controlled ovarian stimulation (COS) has been reported for over 25 years. Yet doubts remain regarding the mechanisms at play in this phenomenon and its net consequences on assisted reproductive technology outcome, which is known to occur in poor and good assisted reproductive technology responders. The pathophysiology of end-COS progesterone elevation encountered in gonadotropin-suppressed cycles is different from that prevailing at the time of, and just after, ovulation. The different divergence in practical consequences of end-COS progesterone elevation led to review the progesterone assays developed for measuring progesterone in the luteal phase of the menstrual cycle, but commonly used for measuring all forms of progesterone elevation.

Original language	English
Journal	Fertility and Sterility
Volume	109
Issue number	4
Pages (from-to)	571-576
Number of pages	6
ISSN	0015-0282
DOIs	https://doi.org/10.1016/j.fertnstert.2018.02.137
Publication status	Published - 2018

Keywords

ART
COS
IVF
luteinization
Progesterone

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10.1016/j.fertnstert.2018.02.137

http://www.fertstert.org/article/S0015028218302371/pdf

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title = "Endocrine mechanisms and assay issues in premature progesterone elevation in assisted reproductive technology",

abstract = "Progesterone elevation occurring in the late phases of controlled ovarian stimulation (COS) has been reported for over 25 years. Yet doubts remain regarding the mechanisms at play in this phenomenon and its net consequences on assisted reproductive technology outcome, which is known to occur in poor and good assisted reproductive technology responders. The pathophysiology of end-COS progesterone elevation encountered in gonadotropin-suppressed cycles is different from that prevailing at the time of, and just after, ovulation. The different divergence in practical consequences of end-COS progesterone elevation led to review the progesterone assays developed for measuring progesterone in the luteal phase of the menstrual cycle, but commonly used for measuring all forms of progesterone elevation.",

keywords = "ART, COS, IVF, luteinization, Progesterone",

author = "{de Ziegler}, Dominique and Andersen, {Claus Yding} and Stanczyk, {Frank Z.} and Ayoubi, {Jean Marc}",

year = "2018",

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language = "English",

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pages = "571--576",

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issn = "0015-0282",

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TY - JOUR

T1 - Endocrine mechanisms and assay issues in premature progesterone elevation in assisted reproductive technology

AU - de Ziegler, Dominique

AU - Andersen, Claus Yding

AU - Stanczyk, Frank Z.

AU - Ayoubi, Jean Marc

PY - 2018

Y1 - 2018

N2 - Progesterone elevation occurring in the late phases of controlled ovarian stimulation (COS) has been reported for over 25 years. Yet doubts remain regarding the mechanisms at play in this phenomenon and its net consequences on assisted reproductive technology outcome, which is known to occur in poor and good assisted reproductive technology responders. The pathophysiology of end-COS progesterone elevation encountered in gonadotropin-suppressed cycles is different from that prevailing at the time of, and just after, ovulation. The different divergence in practical consequences of end-COS progesterone elevation led to review the progesterone assays developed for measuring progesterone in the luteal phase of the menstrual cycle, but commonly used for measuring all forms of progesterone elevation.

AB - Progesterone elevation occurring in the late phases of controlled ovarian stimulation (COS) has been reported for over 25 years. Yet doubts remain regarding the mechanisms at play in this phenomenon and its net consequences on assisted reproductive technology outcome, which is known to occur in poor and good assisted reproductive technology responders. The pathophysiology of end-COS progesterone elevation encountered in gonadotropin-suppressed cycles is different from that prevailing at the time of, and just after, ovulation. The different divergence in practical consequences of end-COS progesterone elevation led to review the progesterone assays developed for measuring progesterone in the luteal phase of the menstrual cycle, but commonly used for measuring all forms of progesterone elevation.

KW - ART

KW - COS

KW - IVF

KW - luteinization

KW - Progesterone

U2 - 10.1016/j.fertnstert.2018.02.137

DO - 10.1016/j.fertnstert.2018.02.137

M3 - Review

C2 - 29653702

AN - SCOPUS:85045038423

SN - 0015-0282

VL - 109

SP - 571

EP - 576

JO - Fertility and Sterility

JF - Fertility and Sterility

IS - 4

ER -

Endocrine mechanisms and assay issues in premature progesterone elevation in assisted reproductive technology

Abstract

Keywords

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