In vitro effect of chloroquine, mefloquine and quinine on human lymphocyte proliferative responses to malaria antigens and other antigens/mitogens

I C Bygbjerg; T G Theander; B J Andersen; H Flachs; S Jepsen; P B Larsen

In vitro effect of chloroquine, mefloquine and quinine on human lymphocyte proliferative responses to malaria antigens and other antigens/mitogens

I C Bygbjerg, T G Theander, B J Andersen, H Flachs, S Jepsen, P B Larsen

Department of Immunology and Microbiology

14 Citations (Scopus)

Abstract

The effect of 3 antimalarial quinoline derivatives, chloroquine, mefloquine and quinine on human blood mononuclear cells in vitro was studied. High concentrations profoundly suppressed the proliferation of mitogen- and antigen-stimulated lymphocytes, as indicated by decreased 14C-thymidine incorporation. On a weight base, the most potent drug was mefloquine. At clinically relevant doses, chloroquine and mefloquine did not affect the response to malaria antigens, but mefloquine decreased the response to phytohaemagglutinin; quinine suppressed the response to all mitogens (with the exception of pokeweed mitogen) and antigens studied, including P. falciparum merozoites. The drugs' potential adverse effect on the immune system is discussed.

Original language	English
Journal	Tropical Medicine and Parasitology
Volume	37
Issue number	3
Pages (from-to)	245-7
Number of pages	2
ISSN	0177-2392
Publication status	Published - 1986

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@article{548dd220a0dd11dd86a6000ea68e967b,

title = "In vitro effect of chloroquine, mefloquine and quinine on human lymphocyte proliferative responses to malaria antigens and other antigens/mitogens",

abstract = "The effect of 3 antimalarial quinoline derivatives, chloroquine, mefloquine and quinine on human blood mononuclear cells in vitro was studied. High concentrations profoundly suppressed the proliferation of mitogen- and antigen-stimulated lymphocytes, as indicated by decreased 14C-thymidine incorporation. On a weight base, the most potent drug was mefloquine. At clinically relevant doses, chloroquine and mefloquine did not affect the response to malaria antigens, but mefloquine decreased the response to phytohaemagglutinin; quinine suppressed the response to all mitogens (with the exception of pokeweed mitogen) and antigens studied, including P. falciparum merozoites. The drugs' potential adverse effect on the immune system is discussed.",

author = "Bygbjerg, {I C} and Theander, {T G} and Andersen, {B J} and H Flachs and S Jepsen and Larsen, {P B}",

note = "Keywords: Adult; Antigens, Fungal; Antigens, Protozoan; Candida albicans; Chloroquine; Humans; Lymphocyte Activation; Mefloquine; Mitogens; Plasmodium falciparum; Quinine; Quinolines; Tuberculin",

year = "1986",

language = "English",

volume = "37",

pages = "245--7",

journal = "Tropical Medicine and Parasitology",

issn = "0177-2392",

publisher = "Wiley-Blackwell",

number = "3",

}

TY - JOUR

T1 - In vitro effect of chloroquine, mefloquine and quinine on human lymphocyte proliferative responses to malaria antigens and other antigens/mitogens

AU - Bygbjerg, I C

AU - Theander, T G

AU - Andersen, B J

AU - Flachs, H

AU - Jepsen, S

AU - Larsen, P B

N1 - Keywords: Adult; Antigens, Fungal; Antigens, Protozoan; Candida albicans; Chloroquine; Humans; Lymphocyte Activation; Mefloquine; Mitogens; Plasmodium falciparum; Quinine; Quinolines; Tuberculin

PY - 1986

Y1 - 1986

N2 - The effect of 3 antimalarial quinoline derivatives, chloroquine, mefloquine and quinine on human blood mononuclear cells in vitro was studied. High concentrations profoundly suppressed the proliferation of mitogen- and antigen-stimulated lymphocytes, as indicated by decreased 14C-thymidine incorporation. On a weight base, the most potent drug was mefloquine. At clinically relevant doses, chloroquine and mefloquine did not affect the response to malaria antigens, but mefloquine decreased the response to phytohaemagglutinin; quinine suppressed the response to all mitogens (with the exception of pokeweed mitogen) and antigens studied, including P. falciparum merozoites. The drugs' potential adverse effect on the immune system is discussed.

AB - The effect of 3 antimalarial quinoline derivatives, chloroquine, mefloquine and quinine on human blood mononuclear cells in vitro was studied. High concentrations profoundly suppressed the proliferation of mitogen- and antigen-stimulated lymphocytes, as indicated by decreased 14C-thymidine incorporation. On a weight base, the most potent drug was mefloquine. At clinically relevant doses, chloroquine and mefloquine did not affect the response to malaria antigens, but mefloquine decreased the response to phytohaemagglutinin; quinine suppressed the response to all mitogens (with the exception of pokeweed mitogen) and antigens studied, including P. falciparum merozoites. The drugs' potential adverse effect on the immune system is discussed.

M3 - Journal article

C2 - 3538350

SN - 0177-2392

VL - 37

SP - 245

EP - 247

JO - Tropical Medicine and Parasitology

JF - Tropical Medicine and Parasitology

IS - 3

ER -

In vitro effect of chloroquine, mefloquine and quinine on human lymphocyte proliferative responses to malaria antigens and other antigens/mitogens

Abstract

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