Elevated circulating leptin levels in arterial hypertension: relationship to arteriovenous overflow and extraction of leptin

TY - JOUR

T1 - Elevated circulating leptin levels in arterial hypertension: relationship to arteriovenous overflow and extraction of leptin

AU - Henriksen, Jens Henrik Sahl

AU - Holst, J J

AU - Moller, S

AU - Andersen, U B

AU - Bendtsen, F

AU - Jensen, G

N1 - Keywords: Adult; Aged; Blood Pressure; Body Mass Index; Case-Control Studies; Female; Humans; Hypertension; Insulin; Kidney; Least-Squares Analysis; Leptin; Liver; Male; Middle Aged; Radioimmunoassay; Renin; Statistics, Nonparametric

PY - 2000

Y1 - 2000

N2 - Leptin, a peptide hormone produced mainly in fat cells, appears to be important for the regulation of metabolism, insulin secretion/sensitivity and body weight. Recently, elevated plasma leptin levels have been reported in patients with arterial hypertension. Because a change in circulating leptin concentrations in such patients could be caused by altered rates of production or disposal, or both, the aim of the present study was to identify regions of leptin overflow into the bloodstream and of leptin extraction. Patients with arterial hypertension (n=12) and normotensive controls (n=20) were studied during catheterization with elective blood sampling from different vascular beds (artery, and renal, hepatic, iliac and cubital veins). Plasma leptin was determined by a radioimmunoassay. Patients with hypertension had significantly elevated levels of circulating leptin (12.8 ng/l, compared with 4.1 ng/l in the controls; P<0.001), and this was also the case when adjusted for body mass index (BMI) [0.435 and 0.167 ng/l per unit BMI (kg/m(2)) respectively; P<0.001]. Circulating leptin was directly related to arterial blood pressure (r=0.38-0.62, P

AB - Leptin, a peptide hormone produced mainly in fat cells, appears to be important for the regulation of metabolism, insulin secretion/sensitivity and body weight. Recently, elevated plasma leptin levels have been reported in patients with arterial hypertension. Because a change in circulating leptin concentrations in such patients could be caused by altered rates of production or disposal, or both, the aim of the present study was to identify regions of leptin overflow into the bloodstream and of leptin extraction. Patients with arterial hypertension (n=12) and normotensive controls (n=20) were studied during catheterization with elective blood sampling from different vascular beds (artery, and renal, hepatic, iliac and cubital veins). Plasma leptin was determined by a radioimmunoassay. Patients with hypertension had significantly elevated levels of circulating leptin (12.8 ng/l, compared with 4.1 ng/l in the controls; P<0.001), and this was also the case when adjusted for body mass index (BMI) [0.435 and 0.167 ng/l per unit BMI (kg/m(2)) respectively; P<0.001]. Circulating leptin was directly related to arterial blood pressure (r=0.38-0.62, P

M3 - Journal article

C2 - 11099396

SN - 0143-5221

VL - 99

SP - 527

EP - 534

JO - Clinical Science

JF - Clinical Science

IS - 6

ER -