Elemental Constituents of Particulate Matter and Newborn's Size in Eight European Cohorts

Marie Pedersen; Ulrike Gehring; Rob Beelen; Meng Wang; Lise Giorgis-Allemand; Anne-Marie Nybo Andersen; Xavier Basagaña; Claire Bernard; Marta Cirach; Francesco Forastiere; Kees de Hoogh; Regina Gražulevičienė; Olena Gruzieva; Gerard Hoek; Aleksandra Jedynska; Claudia Klümper; Ingeborg M Kooter; Ursula Krämer; Jaakko Kukkonen; Daniela Porta; Dirkje S Postma; Ole Raaschou-Nielsen; Lenie van Rossem; Jordi Sunyer; Mette Sørensen; Ming-Yi Tsai; Tanja G Vrijkotte; Michael Wilhelm; Mark J Nieuwenhuijsen; Göran Pershagen; Bert Brunekreef; Manolis Kogevinas; Rémy Slama

doi:10.1289/ehp.1409546

Elemental Constituents of Particulate Matter and Newborn's Size in Eight European Cohorts

Marie Pedersen, Ulrike Gehring, Rob Beelen, Meng Wang, Lise Giorgis-Allemand, Anne-Marie Nybo Andersen, Xavier Basagaña, Claire Bernard, Marta Cirach, Francesco Forastiere, Kees de Hoogh, Regina Gražulevičienė, Olena Gruzieva, Gerard Hoek, Aleksandra Jedynska, Claudia Klümper, Ingeborg M Kooter, Ursula Krämer, Jaakko Kukkonen, Daniela PortaDirkje S Postma, Ole Raaschou-Nielsen, Lenie van Rossem, Jordi Sunyer, Mette Sørensen, Ming-Yi Tsai, Tanja G Vrijkotte, Michael Wilhelm, Mark J Nieuwenhuijsen, Göran Pershagen, Bert Brunekreef, Manolis Kogevinas, Rémy Slama

Section of Social Medicine

42 Citations (Scopus)

Abstract

Background: The health effects of suspended particulate matter (PM) may depend on its chemical composition. Associations between maternal exposure to chemical constituents of PM and newborn’s size have been little examined. Objective: We aimed to investigate the associations of exposure to elemental constituents of PM with term low birth weight (LBW; weight < 2,500 g among births after 37 weeks of gestation), mean birth weight, and head circumference, relying on standardized fine-scale exposure assessment and with extensive control for potential confounders. Methods: We pooled data from eight European cohorts comprising 34,923 singleton births in 1994-2008. Annual average concentrations of elemental constituents of PM ≤ 2.5 and ≤ 10 μm (PM_2.5 and PM₁₀) at maternal home addresses during pregnancy were estimated using land-use regression models. Adjusted associations between each birth measurement and concentrations of eight elements (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) were calculated using random-effects regression on pooled data. Results: A 200-ng/m³ increase in sulfur in PM_2.5 was associated with an increased risk of LBW (adjusted odds ratio = 1.36; 95% confidence interval: 1.17, 1.58). Increased nickel and zinc in PM_2.5 concentrations were also associated with an increased risk of LBW. Head circumference was reduced at higher exposure to all elements except potassium. All associations with sulfur were most robust to adjustment for PM_2.5 mass concentration. All results were similar for PM₁₀. conclusion: Sulfur, reflecting secondary combustion particles in this study, may adversely affect LBW and head circumference, independently of particle mass.

Original language	English
Journal	Environmental Health Perspectives
Volume	124
Issue number	1
Pages (from-to)	141-150
Number of pages	10
ISSN	0091-6765
DOIs	https://doi.org/10.1289/ehp.1409546
Publication status	Published - Jan 2016

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Pedersen, M., Gehring, U., Beelen, R., Wang, M., Giorgis-Allemand, L., Andersen, A-M. N., Basagaña, X., Bernard, C., Cirach, M., Forastiere, F., de Hoogh, K., Gražulevičienė, R., Gruzieva, O., Hoek, G., Jedynska, A., Klümper, C., Kooter, I. M., Krämer, U., Kukkonen, J., ... Slama, R. (2016). Elemental Constituents of Particulate Matter and Newborn's Size in Eight European Cohorts. Environmental Health Perspectives, 124(1), 141-150. https://doi.org/10.1289/ehp.1409546

Pedersen, M, Gehring, U, Beelen, R, Wang, M, Giorgis-Allemand, L, Andersen, A-MN, Basagaña, X, Bernard, C, Cirach, M, Forastiere, F, de Hoogh, K, Gražulevičienė, R, Gruzieva, O, Hoek, G, Jedynska, A, Klümper, C, Kooter, IM, Krämer, U, Kukkonen, J, Porta, D, Postma, DS, Raaschou-Nielsen, O, van Rossem, L, Sunyer, J, Sørensen, M, Tsai, M-Y, Vrijkotte, TG, Wilhelm, M, Nieuwenhuijsen, MJ, Pershagen, G, Brunekreef, B, Kogevinas, M & Slama, R 2016, 'Elemental Constituents of Particulate Matter and Newborn's Size in Eight European Cohorts', Environmental Health Perspectives, vol. 124, no. 1, pp. 141-150. https://doi.org/10.1289/ehp.1409546

@article{0f30aea308e54ec7b1428928c534f048,

title = "Elemental Constituents of Particulate Matter and Newborn's Size in Eight European Cohorts",

abstract = "Background: The health effects of suspended particulate matter (PM) may depend on its chemical composition. Associations between maternal exposure to chemical constituents of PM and newborn{\textquoteright}s size have been little examined. Objective: We aimed to investigate the associations of exposure to elemental constituents of PM with term low birth weight (LBW; weight < 2,500 g among births after 37 weeks of gestation), mean birth weight, and head circumference, relying on standardized fine-scale exposure assessment and with extensive control for potential confounders. Methods: We pooled data from eight European cohorts comprising 34,923 singleton births in 1994-2008. Annual average concentrations of elemental constituents of PM ≤ 2.5 and ≤ 10 μm (PM2.5 and PM10) at maternal home addresses during pregnancy were estimated using land-use regression models. Adjusted associations between each birth measurement and concentrations of eight elements (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) were calculated using random-effects regression on pooled data. Results: A 200-ng/m3 increase in sulfur in PM2.5 was associated with an increased risk of LBW (adjusted odds ratio = 1.36; 95% confidence interval: 1.17, 1.58). Increased nickel and zinc in PM2.5 concentrations were also associated with an increased risk of LBW. Head circumference was reduced at higher exposure to all elements except potassium. All associations with sulfur were most robust to adjustment for PM2.5 mass concentration. All results were similar for PM10. conclusion: Sulfur, reflecting secondary combustion particles in this study, may adversely affect LBW and head circumference, independently of particle mass.",

author = "Marie Pedersen and Ulrike Gehring and Rob Beelen and Meng Wang and Lise Giorgis-Allemand and Andersen, {Anne-Marie Nybo} and Xavier Basaga{\~n}a and Claire Bernard and Marta Cirach and Francesco Forastiere and {de Hoogh}, Kees and Regina Gra{\v z}ulevi{\v c}ienė and Olena Gruzieva and Gerard Hoek and Aleksandra Jedynska and Claudia Kl{\"u}mper and Kooter, {Ingeborg M} and Ursula Kr{\"a}mer and Jaakko Kukkonen and Daniela Porta and Postma, {Dirkje S} and Ole Raaschou-Nielsen and {van Rossem}, Lenie and Jordi Sunyer and Mette S{\o}rensen and Ming-Yi Tsai and Vrijkotte, {Tanja G} and Michael Wilhelm and Nieuwenhuijsen, {Mark J} and G{\"o}ran Pershagen and Bert Brunekreef and Manolis Kogevinas and R{\'e}my Slama",

year = "2016",

month = jan,

doi = "10.1289/ehp.1409546",

language = "English",

volume = "124",

pages = "141--150",

journal = "Environmental Health Perspectives",

issn = "0091-6765",

publisher = "National Institute of Environmental Health Sciences",

number = "1",

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TY - JOUR

T1 - Elemental Constituents of Particulate Matter and Newborn's Size in Eight European Cohorts

AU - Pedersen, Marie

AU - Gehring, Ulrike

AU - Beelen, Rob

AU - Wang, Meng

AU - Giorgis-Allemand, Lise

AU - Andersen, Anne-Marie Nybo

AU - Basagaña, Xavier

AU - Bernard, Claire

AU - Cirach, Marta

AU - Forastiere, Francesco

AU - de Hoogh, Kees

AU - Gražulevičienė, Regina

AU - Gruzieva, Olena

AU - Hoek, Gerard

AU - Jedynska, Aleksandra

AU - Klümper, Claudia

AU - Kooter, Ingeborg M

AU - Krämer, Ursula

AU - Kukkonen, Jaakko

AU - Porta, Daniela

AU - Postma, Dirkje S

AU - Raaschou-Nielsen, Ole

AU - van Rossem, Lenie

AU - Sunyer, Jordi

AU - Sørensen, Mette

AU - Tsai, Ming-Yi

AU - Vrijkotte, Tanja G

AU - Wilhelm, Michael

AU - Nieuwenhuijsen, Mark J

AU - Pershagen, Göran

AU - Brunekreef, Bert

AU - Kogevinas, Manolis

AU - Slama, Rémy

PY - 2016/1

Y1 - 2016/1

N2 - Background: The health effects of suspended particulate matter (PM) may depend on its chemical composition. Associations between maternal exposure to chemical constituents of PM and newborn’s size have been little examined. Objective: We aimed to investigate the associations of exposure to elemental constituents of PM with term low birth weight (LBW; weight < 2,500 g among births after 37 weeks of gestation), mean birth weight, and head circumference, relying on standardized fine-scale exposure assessment and with extensive control for potential confounders. Methods: We pooled data from eight European cohorts comprising 34,923 singleton births in 1994-2008. Annual average concentrations of elemental constituents of PM ≤ 2.5 and ≤ 10 μm (PM2.5 and PM10) at maternal home addresses during pregnancy were estimated using land-use regression models. Adjusted associations between each birth measurement and concentrations of eight elements (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) were calculated using random-effects regression on pooled data. Results: A 200-ng/m3 increase in sulfur in PM2.5 was associated with an increased risk of LBW (adjusted odds ratio = 1.36; 95% confidence interval: 1.17, 1.58). Increased nickel and zinc in PM2.5 concentrations were also associated with an increased risk of LBW. Head circumference was reduced at higher exposure to all elements except potassium. All associations with sulfur were most robust to adjustment for PM2.5 mass concentration. All results were similar for PM10. conclusion: Sulfur, reflecting secondary combustion particles in this study, may adversely affect LBW and head circumference, independently of particle mass.

AB - Background: The health effects of suspended particulate matter (PM) may depend on its chemical composition. Associations between maternal exposure to chemical constituents of PM and newborn’s size have been little examined. Objective: We aimed to investigate the associations of exposure to elemental constituents of PM with term low birth weight (LBW; weight < 2,500 g among births after 37 weeks of gestation), mean birth weight, and head circumference, relying on standardized fine-scale exposure assessment and with extensive control for potential confounders. Methods: We pooled data from eight European cohorts comprising 34,923 singleton births in 1994-2008. Annual average concentrations of elemental constituents of PM ≤ 2.5 and ≤ 10 μm (PM2.5 and PM10) at maternal home addresses during pregnancy were estimated using land-use regression models. Adjusted associations between each birth measurement and concentrations of eight elements (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) were calculated using random-effects regression on pooled data. Results: A 200-ng/m3 increase in sulfur in PM2.5 was associated with an increased risk of LBW (adjusted odds ratio = 1.36; 95% confidence interval: 1.17, 1.58). Increased nickel and zinc in PM2.5 concentrations were also associated with an increased risk of LBW. Head circumference was reduced at higher exposure to all elements except potassium. All associations with sulfur were most robust to adjustment for PM2.5 mass concentration. All results were similar for PM10. conclusion: Sulfur, reflecting secondary combustion particles in this study, may adversely affect LBW and head circumference, independently of particle mass.

U2 - 10.1289/ehp.1409546

DO - 10.1289/ehp.1409546

M3 - Journal article

C2 - 26046983

SN - 0091-6765

VL - 124

SP - 141

EP - 150

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

IS - 1

ER -

Elemental Constituents of Particulate Matter and Newborn's Size in Eight European Cohorts

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