Electrochemical studies of the interactional mechanism and scavenging activity of antioxidants towards dinitroaromatics

Nasima Arshad; Naveed K Janjua; Athar Y. Khan; Javeed H Zaidi; Leif Horsfelt Skibsted

doi:10.1007/s00706-011-0606-3

Electrochemical studies of the interactional mechanism and scavenging activity of antioxidants towards dinitroaromatics

Nasima Arshad, Naveed K Janjua, Athar Y. Khan, Javeed H Zaidi, Leif Horsfelt Skibsted

5 Citations (Scopus)

Abstract

In the work discussed in this paper, cyclic voltammetric results obtained for the interaction of ascorbic acid, β-carotene, and three structurally related flavonoids (quercetin, rutin, and morin) with the anion radical of 1,3-dinitrobenzene were used to determine their antioxidant activity. The extent of the antioxidant-anion radical interactions was measured as the antioxidant activity coefficient. Higher values of this coefficient obtained for the three flavonoids in DMF are indicative of their greater antioxidant activity than ascorbic acid and β-carotene in this solvent. On the basis of cyclic voltammetric responses, a possible mechanism of the reaction of the reduction product of 1,3-dinitrobenzene with the antioxidants is proposed. Hyperchem PM3 quantum mechanical semi-empirical calculations of charges on reactive sites of the antioxidants and the 1,3-dinitrobenzene anion radical were also carried out; the results obtained supported the proposed mechanism of interaction.

Original language	English
Journal	Monatshefte fuer Chemie
Volume	143
Pages (from-to)	377-383
Number of pages	7
ISSN	0026-9247
DOIs	https://doi.org/10.1007/s00706-011-0606-3
Publication status	Published - Mar 2012

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title = "Electrochemical studies of the interactional mechanism and scavenging activity of antioxidants towards dinitroaromatics",

abstract = "In the work discussed in this paper, cyclic voltammetric results obtained for the interaction of ascorbic acid, β-carotene, and three structurally related flavonoids (quercetin, rutin, and morin) with the anion radical of 1,3-dinitrobenzene were used to determine their antioxidant activity. The extent of the antioxidant-anion radical interactions was measured as the antioxidant activity coefficient. Higher values of this coefficient obtained for the three flavonoids in DMF are indicative of their greater antioxidant activity than ascorbic acid and β-carotene in this solvent. On the basis of cyclic voltammetric responses, a possible mechanism of the reaction of the reduction product of 1,3-dinitrobenzene with the antioxidants is proposed. Hyperchem PM3 quantum mechanical semi-empirical calculations of charges on reactive sites of the antioxidants and the 1,3-dinitrobenzene anion radical were also carried out; the results obtained supported the proposed mechanism of interaction.",

author = "Nasima Arshad and Janjua, {Naveed K} and Khan, {Athar Y.} and Zaidi, {Javeed H} and Skibsted, {Leif Horsfelt}",

year = "2012",

month = mar,

doi = "10.1007/s00706-011-0606-3",

language = "English",

volume = "143",

pages = "377--383",

journal = "Monatshefte fur Chemie",

issn = "0026-9247",

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TY - JOUR

T1 - Electrochemical studies of the interactional mechanism and scavenging activity of antioxidants towards dinitroaromatics

AU - Arshad, Nasima

AU - Janjua, Naveed K

AU - Khan, Athar Y.

AU - Zaidi, Javeed H

AU - Skibsted, Leif Horsfelt

PY - 2012/3

Y1 - 2012/3

N2 - In the work discussed in this paper, cyclic voltammetric results obtained for the interaction of ascorbic acid, β-carotene, and three structurally related flavonoids (quercetin, rutin, and morin) with the anion radical of 1,3-dinitrobenzene were used to determine their antioxidant activity. The extent of the antioxidant-anion radical interactions was measured as the antioxidant activity coefficient. Higher values of this coefficient obtained for the three flavonoids in DMF are indicative of their greater antioxidant activity than ascorbic acid and β-carotene in this solvent. On the basis of cyclic voltammetric responses, a possible mechanism of the reaction of the reduction product of 1,3-dinitrobenzene with the antioxidants is proposed. Hyperchem PM3 quantum mechanical semi-empirical calculations of charges on reactive sites of the antioxidants and the 1,3-dinitrobenzene anion radical were also carried out; the results obtained supported the proposed mechanism of interaction.

AB - In the work discussed in this paper, cyclic voltammetric results obtained for the interaction of ascorbic acid, β-carotene, and three structurally related flavonoids (quercetin, rutin, and morin) with the anion radical of 1,3-dinitrobenzene were used to determine their antioxidant activity. The extent of the antioxidant-anion radical interactions was measured as the antioxidant activity coefficient. Higher values of this coefficient obtained for the three flavonoids in DMF are indicative of their greater antioxidant activity than ascorbic acid and β-carotene in this solvent. On the basis of cyclic voltammetric responses, a possible mechanism of the reaction of the reduction product of 1,3-dinitrobenzene with the antioxidants is proposed. Hyperchem PM3 quantum mechanical semi-empirical calculations of charges on reactive sites of the antioxidants and the 1,3-dinitrobenzene anion radical were also carried out; the results obtained supported the proposed mechanism of interaction.

U2 - 10.1007/s00706-011-0606-3

DO - 10.1007/s00706-011-0606-3

M3 - Journal article

SN - 0026-9247

VL - 143

SP - 377

EP - 383

JO - Monatshefte fur Chemie

JF - Monatshefte fur Chemie

ER -

Electrochemical studies of the interactional mechanism and scavenging activity of antioxidants towards dinitroaromatics

Abstract

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