TY - RPRT
T1 - EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2013. Scientific Opinion on Dietary Reference Values for manganese
AU - Publication, EFSA
AU - Tetens, Inge
PY - 2013
Y1 - 2013
N2 - Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies (NDA) derived Dietary Reference Values (DRVs) for manganese. Manganese is an essential dietary mineral which is a component of a number of metalloenzymes involved in amino acid, lipid and carbohydrate metabolism. A specific manganese deficiency syndrome has not been described in humans. The body is able to adapt to a wide range of manganese intakes by regulating both efficiency of absorption in the intestine and the quantity excreted via bile. There are no reliable and validated biomarkers of manganese intake or status and data on manganese intakes versus health outcomes are not available for DRVs for manganese. As there is insufficient evidence available to derive an average requirement or a population reference intake, an Adequate Intake (AI) is proposed. Mean intakes of manganese in adults in the EU are around 3 mg/day. In addition, null or positive balances have consistently been observed with intakes of manganese above 2.5 mg/day. An AI of 3 mg/day is proposed for adults, including pregnant and lactating women. For infants aged from 7 to 11 months, an AI of 0.02–0.5 mg/day is proposed, which reflects the wide range of manganese intakes that appear to be adequate for this age group. The AI for children and adolescents is based on extrapolation from the adult AI using isometric scaling and reference body weights of the respective age groups.
AB - Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies (NDA) derived Dietary Reference Values (DRVs) for manganese. Manganese is an essential dietary mineral which is a component of a number of metalloenzymes involved in amino acid, lipid and carbohydrate metabolism. A specific manganese deficiency syndrome has not been described in humans. The body is able to adapt to a wide range of manganese intakes by regulating both efficiency of absorption in the intestine and the quantity excreted via bile. There are no reliable and validated biomarkers of manganese intake or status and data on manganese intakes versus health outcomes are not available for DRVs for manganese. As there is insufficient evidence available to derive an average requirement or a population reference intake, an Adequate Intake (AI) is proposed. Mean intakes of manganese in adults in the EU are around 3 mg/day. In addition, null or positive balances have consistently been observed with intakes of manganese above 2.5 mg/day. An AI of 3 mg/day is proposed for adults, including pregnant and lactating women. For infants aged from 7 to 11 months, an AI of 0.02–0.5 mg/day is proposed, which reflects the wide range of manganese intakes that appear to be adequate for this age group. The AI for children and adolescents is based on extrapolation from the adult AI using isometric scaling and reference body weights of the respective age groups.
U2 - 10.2903/j.efsa.2013.3419
DO - 10.2903/j.efsa.2013.3419
M3 - Report
BT - EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2013. Scientific Opinion on Dietary Reference Values for manganese
PB - European Food Safety Authority
ER -