Efficacy of recreational football on bone health, body composition, and physical functioning in men with prostate cancer undergoing androgen deprivation therapy: 32-week follow-up of the FC prostate randomised controlled trial

TY - JOUR

T1 - Efficacy of recreational football on bone health, body composition, and physical functioning in men with prostate cancer undergoing androgen deprivation therapy

T2 - 32-week follow-up of the FC prostate randomised controlled trial

AU - Uth, Jacob

AU - Hornstrup, Therese

AU - Christensen, Jesper F

AU - Christensen, Karl Bang

AU - Jørgensen, Niclas Rye

AU - Schmidt, Jakob Friis

AU - Brasso, Klaus

AU - Jakobsen, Markus Due

AU - Sundstrup, Emil

AU - Andersen, Lars Louis

AU - Rørth, Mikael Rahbek

AU - Midtgaard, Julie

AU - Krustrup, Peter

AU - Helge, Eva Wulff

N1 - CURIS 2016 NEXS 087

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Summary: Androgen deprivation therapy (ADT) for prostate cancer (PCa) impairs musculoskeletal health. We evaluated the efficacy of 32-week football training on bone mineral density (BMD) and physical functioning in men undergoing ADT for PCa. Football training improved the femoral shaft and total hip BMD and physical functioning parameters compared to control. Introduction: ADT is a mainstay in PCa management. Side effects include decreased bone and muscle strength and increased fracture rates. The purpose of the present study was to evaluate the effects of 32 weeks of football training on BMD, bone turnover markers (BTMs), body composition, and physical functioning in men with PCa undergoing ADT. Methods: Men receiving ADT >6 months (n = 57) were randomly allocated to a football training group (FTG) (n = 29) practising 2–3 times per week for 45–60 min or to a standard care control group (CON) (n = 28) for 32 weeks. Outcomes were total hip, femoral shaft, femoral neck and lumbar spine (L2-L4) BMD and systemic BTMs (procollagen type 1 amino-terminal propeptide, osteocalcin, C-terminal telopeptide of type 1 collagen). Additionally, physical functioning (postural balance, jump height, repeated chair rise, stair climbing) was evaluated. Results: Thirty-two-week follow-up measures were obtained for FTG (n = 21) and for CON (n = 20), respectively. Analysis of mean changes from baseline to 32 weeks showed significant differences between FTG and CON in right (0.015 g/cm2) and left (0.017 g/cm2) total hip and in right (0.018 g/cm2) and left (0.024 g/cm2) femoral shaft BMD, jump height (1.7 cm) and stair climbing (−0.21 s) all in favour of FTG (p < 0.05). No other significant between-group differences were observed. Conclusions: Compared to standard care, 32 weeks of football training improved BMD at clinically important femoral sites and parameters of physical functioning in men undergoing ADT for PCa.

AB - Summary: Androgen deprivation therapy (ADT) for prostate cancer (PCa) impairs musculoskeletal health. We evaluated the efficacy of 32-week football training on bone mineral density (BMD) and physical functioning in men undergoing ADT for PCa. Football training improved the femoral shaft and total hip BMD and physical functioning parameters compared to control. Introduction: ADT is a mainstay in PCa management. Side effects include decreased bone and muscle strength and increased fracture rates. The purpose of the present study was to evaluate the effects of 32 weeks of football training on BMD, bone turnover markers (BTMs), body composition, and physical functioning in men with PCa undergoing ADT. Methods: Men receiving ADT >6 months (n = 57) were randomly allocated to a football training group (FTG) (n = 29) practising 2–3 times per week for 45–60 min or to a standard care control group (CON) (n = 28) for 32 weeks. Outcomes were total hip, femoral shaft, femoral neck and lumbar spine (L2-L4) BMD and systemic BTMs (procollagen type 1 amino-terminal propeptide, osteocalcin, C-terminal telopeptide of type 1 collagen). Additionally, physical functioning (postural balance, jump height, repeated chair rise, stair climbing) was evaluated. Results: Thirty-two-week follow-up measures were obtained for FTG (n = 21) and for CON (n = 20), respectively. Analysis of mean changes from baseline to 32 weeks showed significant differences between FTG and CON in right (0.015 g/cm2) and left (0.017 g/cm2) total hip and in right (0.018 g/cm2) and left (0.024 g/cm2) femoral shaft BMD, jump height (1.7 cm) and stair climbing (−0.21 s) all in favour of FTG (p < 0.05). No other significant between-group differences were observed. Conclusions: Compared to standard care, 32 weeks of football training improved BMD at clinically important femoral sites and parameters of physical functioning in men undergoing ADT for PCa.

U2 - 10.1007/s00198-015-3399-0

DO - 10.1007/s00198-015-3399-0

M3 - Journal article

C2 - 26572756

SN - 0937-941X

VL - 27

SP - 1507

EP - 1518

JO - Osteoporosis International

JF - Osteoporosis International

IS - 4

ER -