Effects of Roux-en-Y Gastric Bypass on Fasting and Postprandial Levels of the Inflammatory Markers YKL-40 and MCP-1 in Patients with Type 2 Diabetes and Glucose Tolerant Subjects

Stine Brinkløv Thomsen; Camilla Noelle Rathcke; Nils Bruun Jørgensen; Sten Madsbad; Henrik Vestergaard

doi:10.1155/2013/361781

Effects of Roux-en-Y Gastric Bypass on Fasting and Postprandial Levels of the Inflammatory Markers YKL-40 and MCP-1 in Patients with Type 2 Diabetes and Glucose Tolerant Subjects

Stine Brinkløv Thomsen, Camilla Noelle Rathcke, Nils Bruun Jørgensen, Sten Madsbad, Henrik Vestergaard

Department of Clinical Medicine

9 Citations (Scopus)

Abstract

Background. The inflammatory markers YKL-40 and monocyte chemoattractant protein-1 (MCP-1) are elevated in morbidly obese patients and decline after weight loss. The objective of our study was to investigate the possible changes of YKL-40 and MCP-1, in both the fasting and the postprandial states, following Roux-en-Y gastric bypass (RYGB) in subjects with type 2 diabetes (T2D) and normal glucose tolerance (NGT). Methods. Ten obese patients with T2D and 10 subjects with NGT were examined in the fasting state and after a standard meal prior to and after (1 week, 3 months, and 1 year) RYGB. Results. Fasting state MCP-1 levels decreased after RYGB in both groups (P values < 0.0001) whereas fasting YKL-40 levels were unchanged (P values ≥ 0.120). Postprandial MCP-1 levels showed a tendency towards a decrease on most study days; however, the changes were only significant at 1 week (P=0.001) and 1 yr (P<0.0001) in the T2D group and at 3 mo after RYGB in the NGT group (P=0.009). YKL-40 levels showed a slight, postprandial suppression on all study days in the T2D group (all P values ≤ 0.021). Conclusions. Fasting MCP-1 levels, but not YKL-40 levels, decrease after RYGB in subjects with T2D and NGT. Postprandial changes of inflammatory markers are discrete and inconsistent.

Original language	English
Article number	361781
Journal	International Journal of Obesity
Volume	2013
Number of pages	10
ISSN	0307-0565
DOIs	https://doi.org/10.1155/2013/361781
Publication status	Published - 2013

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Effects of Roux-en-Y Gastric Bypass on Fasting and Postprandial Levels of the Inflammatory Markers YKL-40 and MCP-1 in Patients with Type 2 Diabetes and Glucose Tolerant Subjects. / Thomsen, Stine Brinkløv; Rathcke, Camilla Noelle; Jørgensen, Nils Bruun et al.
In: International Journal of Obesity, Vol. 2013, 361781, 2013.

Research output: Contribution to journal › Journal article › Research › peer-review

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title = "Effects of Roux-en-Y Gastric Bypass on Fasting and Postprandial Levels of the Inflammatory Markers YKL-40 and MCP-1 in Patients with Type 2 Diabetes and Glucose Tolerant Subjects",

abstract = "Background. The inflammatory markers YKL-40 and monocyte chemoattractant protein-1 (MCP-1) are elevated in morbidly obese patients and decline after weight loss. The objective of our study was to investigate the possible changes of YKL-40 and MCP-1, in both the fasting and the postprandial states, following Roux-en-Y gastric bypass (RYGB) in subjects with type 2 diabetes (T2D) and normal glucose tolerance (NGT). Methods. Ten obese patients with T2D and 10 subjects with NGT were examined in the fasting state and after a standard meal prior to and after (1 week, 3 months, and 1 year) RYGB. Results. Fasting state MCP-1 levels decreased after RYGB in both groups (P values < 0.0001) whereas fasting YKL-40 levels were unchanged (P values ≥ 0.120). Postprandial MCP-1 levels showed a tendency towards a decrease on most study days; however, the changes were only significant at 1 week (P=0.001) and 1 yr (P<0.0001) in the T2D group and at 3 mo after RYGB in the NGT group (P=0.009). YKL-40 levels showed a slight, postprandial suppression on all study days in the T2D group (all P values ≤ 0.021). Conclusions. Fasting MCP-1 levels, but not YKL-40 levels, decrease after RYGB in subjects with T2D and NGT. Postprandial changes of inflammatory markers are discrete and inconsistent.",

author = "Thomsen, {Stine Brinkl{\o}v} and Rathcke, {Camilla Noelle} and J{\o}rgensen, {Nils Bruun} and Sten Madsbad and Henrik Vestergaard",

year = "2013",

doi = "10.1155/2013/361781",

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journal = "International Journal of Obesity",

issn = "0307-0565",

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T1 - Effects of Roux-en-Y Gastric Bypass on Fasting and Postprandial Levels of the Inflammatory Markers YKL-40 and MCP-1 in Patients with Type 2 Diabetes and Glucose Tolerant Subjects

AU - Thomsen, Stine Brinkløv

AU - Rathcke, Camilla Noelle

AU - Jørgensen, Nils Bruun

AU - Madsbad, Sten

AU - Vestergaard, Henrik

PY - 2013

Y1 - 2013

N2 - Background. The inflammatory markers YKL-40 and monocyte chemoattractant protein-1 (MCP-1) are elevated in morbidly obese patients and decline after weight loss. The objective of our study was to investigate the possible changes of YKL-40 and MCP-1, in both the fasting and the postprandial states, following Roux-en-Y gastric bypass (RYGB) in subjects with type 2 diabetes (T2D) and normal glucose tolerance (NGT). Methods. Ten obese patients with T2D and 10 subjects with NGT were examined in the fasting state and after a standard meal prior to and after (1 week, 3 months, and 1 year) RYGB. Results. Fasting state MCP-1 levels decreased after RYGB in both groups (P values < 0.0001) whereas fasting YKL-40 levels were unchanged (P values ≥ 0.120). Postprandial MCP-1 levels showed a tendency towards a decrease on most study days; however, the changes were only significant at 1 week (P=0.001) and 1 yr (P<0.0001) in the T2D group and at 3 mo after RYGB in the NGT group (P=0.009). YKL-40 levels showed a slight, postprandial suppression on all study days in the T2D group (all P values ≤ 0.021). Conclusions. Fasting MCP-1 levels, but not YKL-40 levels, decrease after RYGB in subjects with T2D and NGT. Postprandial changes of inflammatory markers are discrete and inconsistent.

AB - Background. The inflammatory markers YKL-40 and monocyte chemoattractant protein-1 (MCP-1) are elevated in morbidly obese patients and decline after weight loss. The objective of our study was to investigate the possible changes of YKL-40 and MCP-1, in both the fasting and the postprandial states, following Roux-en-Y gastric bypass (RYGB) in subjects with type 2 diabetes (T2D) and normal glucose tolerance (NGT). Methods. Ten obese patients with T2D and 10 subjects with NGT were examined in the fasting state and after a standard meal prior to and after (1 week, 3 months, and 1 year) RYGB. Results. Fasting state MCP-1 levels decreased after RYGB in both groups (P values < 0.0001) whereas fasting YKL-40 levels were unchanged (P values ≥ 0.120). Postprandial MCP-1 levels showed a tendency towards a decrease on most study days; however, the changes were only significant at 1 week (P=0.001) and 1 yr (P<0.0001) in the T2D group and at 3 mo after RYGB in the NGT group (P=0.009). YKL-40 levels showed a slight, postprandial suppression on all study days in the T2D group (all P values ≤ 0.021). Conclusions. Fasting MCP-1 levels, but not YKL-40 levels, decrease after RYGB in subjects with T2D and NGT. Postprandial changes of inflammatory markers are discrete and inconsistent.

U2 - 10.1155/2013/361781

DO - 10.1155/2013/361781

M3 - Journal article

C2 - 24303210

SN - 0307-0565

VL - 2013

JO - International Journal of Obesity

JF - International Journal of Obesity

M1 - 361781

ER -

Effects of Roux-en-Y Gastric Bypass on Fasting and Postprandial Levels of the Inflammatory Markers YKL-40 and MCP-1 in Patients with Type 2 Diabetes and Glucose Tolerant Subjects

Abstract

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