Effects of quorum-sensing on immunoglobulin G responses in a rat model of chronic lung infection with Pseudomonas aeruginosa

TY - JOUR

T1 - Effects of quorum-sensing on immunoglobulin G responses in a rat model of chronic lung infection with Pseudomonas aeruginosa

AU - Wu, Hong

AU - Song, Zhijun

AU - Givskov, Michael

AU - Høiby, Niels

N1 - Keywords: Animals; Antibodies, Bacterial; Bacterial Proteins; Chronic Disease; Disease Models, Animal; Immunoglobulin G; Ligases; Lung Diseases; Mutation; Prognosis; Pseudomonas Infections; Pseudomonas aeruginosa; Rats; Time Factors; Transcription Factors

PY - 2004

Y1 - 2004

N2 - Levels of serum antibodies against Pseudomonas aeruginosa were observed for 106 days in a rat model of chronic lung infection. Significantly weaker responses of serum IgG and IgG1 and a lower ratio of IgG1/IgG2a were found in the rats infected with the quorum-signal-deficient mutant, PAO1 (rhlI, lasI), compared with the wild-type PAO1. Four out of 15 rats infected with wild-type PAO1 contained bacteria in the lungs on day 106, whereas no bacteria were found in the mutant PAO1 group. The results indicate that quorum signals contribute to the persistence of the infection and influence the immune response.

AB - Levels of serum antibodies against Pseudomonas aeruginosa were observed for 106 days in a rat model of chronic lung infection. Significantly weaker responses of serum IgG and IgG1 and a lower ratio of IgG1/IgG2a were found in the rats infected with the quorum-signal-deficient mutant, PAO1 (rhlI, lasI), compared with the wild-type PAO1. Four out of 15 rats infected with wild-type PAO1 contained bacteria in the lungs on day 106, whereas no bacteria were found in the mutant PAO1 group. The results indicate that quorum signals contribute to the persistence of the infection and influence the immune response.

M3 - Journal article

C2 - 14738891

SN - 1286-4579

VL - 6

SP - 34

EP - 37

JO - Microbes and Infection

JF - Microbes and Infection

IS - 1

ER -