Effects of premature birth on the risk for alcoholism appear to be greater in males than females

Ann M Manzardo; Wendy V Madarasz; Elizabeth C Penick; Joachim Knop; Erik Lykke Mortensen; Holger Jelling Sørensen; Jonathan D Mahnken; Ulrik Becker; Elizabeth J Nickel; William F Gabrielli

Effects of premature birth on the risk for alcoholism appear to be greater in males than females

Ann M Manzardo, Wendy V Madarasz, Elizabeth C Penick, Joachim Knop, Erik Lykke Mortensen, Holger Jelling Sørensen, Jonathan D Mahnken, Ulrik Becker, Elizabeth J Nickel, William F Gabrielli

6 Citations (Scopus)

Abstract

Objective: A large Danish birth cohort was used to test the independent and joint effects of perinatal measures associated with premature birth as predictors of the development of alcoholism in male and female subjects. Method: Subjects were born at the Copenhagen University Hospital between 1959 and 1961 (N = 9,125). A comprehensive series of measures was obtained for each of the 8,109 surviving and eligible infants before birth, during birth, shortly after birth, and at 1 year. The adult alcoholism outcome was defi ned as any ICD-10 F10 diagnosis (Mental and behavioral disorders due to alcohol use) or an equivalent ICD-8 diagnosis found in the Danish Psychiatric Central Research Register or the Municipal Alcohol Clinics of Copenhagen by 2007. Results: Multiple perinatal markers of premature birth independently predicted the development of an alcoholism diagnosis in male (n = 310) but not female (n = 138) subjects. Logistic regression modeling with a global prematurity score, adjusted for social status, maternal smoking, and gender, indicated a signifi cant association of prematurity score for males (p <.02), but not females (p =.51), on the risk of developing an alcohol use disorder. Conclusions: The results suggest that neurodevelopmental sequelae of premature birth are associated with gender-specifi c effects on the development of alcoholism in the male baby: small, premature, or growth-delayed male babies appear to be selectively vulnerable to alcoholic drinking years later. The fi ndings implicate neurodevelopmental influences in alcoholism pathophysiology in males and suggest the possibility of distinct, gender-specifi c pathways in the etiology of severe problem drinking.

Original language	English
Journal	Journal of Studies on Alcohol and Drugs
Volume	72
Issue number	3
Pages (from-to)	390-8
Number of pages	9
ISSN	1937-1888
Publication status	Published - 1 May 2011

Keywords

Adult
Alcohol Drinking
Alcoholism
Databases, Factual
Denmark
Female
Hospitals, University
Humans
Logistic Models
Longitudinal Studies
Male
Middle Aged
Pregnancy
Premature Birth
Registries
Risk Factors
Sex Factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084356/?tool=pubmed

Cite this

Manzardo, A. M., Madarasz, W. V., Penick, E. C., Knop, J., Mortensen, E. L., Sørensen, H. J., Mahnken, J. D., Becker, U., Nickel, E. J., & Gabrielli, W. F. (2011). Effects of premature birth on the risk for alcoholism appear to be greater in males than females. Journal of Studies on Alcohol and Drugs, 72(3), 390-8. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084356/?tool=pubmed

Manzardo, AM, Madarasz, WV, Penick, EC, Knop, J, Mortensen, EL, Sørensen, HJ, Mahnken, JD, Becker, U, Nickel, EJ & Gabrielli, WF 2011, 'Effects of premature birth on the risk for alcoholism appear to be greater in males than females', Journal of Studies on Alcohol and Drugs, vol. 72, no. 3, pp. 390-8. <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084356/?tool=pubmed>

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title = "Effects of premature birth on the risk for alcoholism appear to be greater in males than females",

abstract = "Objective: A large Danish birth cohort was used to test the independent and joint effects of perinatal measures associated with premature birth as predictors of the development of alcoholism in male and female subjects. Method: Subjects were born at the Copenhagen University Hospital between 1959 and 1961 (N = 9,125). A comprehensive series of measures was obtained for each of the 8,109 surviving and eligible infants before birth, during birth, shortly after birth, and at 1 year. The adult alcoholism outcome was defi ned as any ICD-10 F10 diagnosis (Mental and behavioral disorders due to alcohol use) or an equivalent ICD-8 diagnosis found in the Danish Psychiatric Central Research Register or the Municipal Alcohol Clinics of Copenhagen by 2007. Results: Multiple perinatal markers of premature birth independently predicted the development of an alcoholism diagnosis in male (n = 310) but not female (n = 138) subjects. Logistic regression modeling with a global prematurity score, adjusted for social status, maternal smoking, and gender, indicated a signifi cant association of prematurity score for males (p <.02), but not females (p =.51), on the risk of developing an alcohol use disorder. Conclusions: The results suggest that neurodevelopmental sequelae of premature birth are associated with gender-specifi c effects on the development of alcoholism in the male baby: small, premature, or growth-delayed male babies appear to be selectively vulnerable to alcoholic drinking years later. The fi ndings implicate neurodevelopmental influences in alcoholism pathophysiology in males and suggest the possibility of distinct, gender-specifi c pathways in the etiology of severe problem drinking.",

keywords = "Adult, Alcohol Drinking, Alcoholism, Databases, Factual, Denmark, Female, Hospitals, University, Humans, Logistic Models, Longitudinal Studies, Male, Middle Aged, Pregnancy, Premature Birth, Registries, Risk Factors, Sex Factors",

author = "Manzardo, {Ann M} and Madarasz, {Wendy V} and Penick, {Elizabeth C} and Joachim Knop and Mortensen, {Erik Lykke} and S{\o}rensen, {Holger Jelling} and Mahnken, {Jonathan D} and Ulrik Becker and Nickel, {Elizabeth J} and Gabrielli, {William F}",

year = "2011",

month = may,

day = "1",

language = "English",

volume = "72",

pages = "390--8",

journal = "Journal of Studies on Alcohol and Drugs",

issn = "1937-1888",

publisher = "Alcohol Research Documentation, Inc.",

number = "3",

}

TY - JOUR

T1 - Effects of premature birth on the risk for alcoholism appear to be greater in males than females

AU - Manzardo, Ann M

AU - Madarasz, Wendy V

AU - Penick, Elizabeth C

AU - Knop, Joachim

AU - Mortensen, Erik Lykke

AU - Sørensen, Holger Jelling

AU - Mahnken, Jonathan D

AU - Becker, Ulrik

AU - Nickel, Elizabeth J

AU - Gabrielli, William F

PY - 2011/5/1

Y1 - 2011/5/1

N2 - Objective: A large Danish birth cohort was used to test the independent and joint effects of perinatal measures associated with premature birth as predictors of the development of alcoholism in male and female subjects. Method: Subjects were born at the Copenhagen University Hospital between 1959 and 1961 (N = 9,125). A comprehensive series of measures was obtained for each of the 8,109 surviving and eligible infants before birth, during birth, shortly after birth, and at 1 year. The adult alcoholism outcome was defi ned as any ICD-10 F10 diagnosis (Mental and behavioral disorders due to alcohol use) or an equivalent ICD-8 diagnosis found in the Danish Psychiatric Central Research Register or the Municipal Alcohol Clinics of Copenhagen by 2007. Results: Multiple perinatal markers of premature birth independently predicted the development of an alcoholism diagnosis in male (n = 310) but not female (n = 138) subjects. Logistic regression modeling with a global prematurity score, adjusted for social status, maternal smoking, and gender, indicated a signifi cant association of prematurity score for males (p <.02), but not females (p =.51), on the risk of developing an alcohol use disorder. Conclusions: The results suggest that neurodevelopmental sequelae of premature birth are associated with gender-specifi c effects on the development of alcoholism in the male baby: small, premature, or growth-delayed male babies appear to be selectively vulnerable to alcoholic drinking years later. The fi ndings implicate neurodevelopmental influences in alcoholism pathophysiology in males and suggest the possibility of distinct, gender-specifi c pathways in the etiology of severe problem drinking.

AB - Objective: A large Danish birth cohort was used to test the independent and joint effects of perinatal measures associated with premature birth as predictors of the development of alcoholism in male and female subjects. Method: Subjects were born at the Copenhagen University Hospital between 1959 and 1961 (N = 9,125). A comprehensive series of measures was obtained for each of the 8,109 surviving and eligible infants before birth, during birth, shortly after birth, and at 1 year. The adult alcoholism outcome was defi ned as any ICD-10 F10 diagnosis (Mental and behavioral disorders due to alcohol use) or an equivalent ICD-8 diagnosis found in the Danish Psychiatric Central Research Register or the Municipal Alcohol Clinics of Copenhagen by 2007. Results: Multiple perinatal markers of premature birth independently predicted the development of an alcoholism diagnosis in male (n = 310) but not female (n = 138) subjects. Logistic regression modeling with a global prematurity score, adjusted for social status, maternal smoking, and gender, indicated a signifi cant association of prematurity score for males (p <.02), but not females (p =.51), on the risk of developing an alcohol use disorder. Conclusions: The results suggest that neurodevelopmental sequelae of premature birth are associated with gender-specifi c effects on the development of alcoholism in the male baby: small, premature, or growth-delayed male babies appear to be selectively vulnerable to alcoholic drinking years later. The fi ndings implicate neurodevelopmental influences in alcoholism pathophysiology in males and suggest the possibility of distinct, gender-specifi c pathways in the etiology of severe problem drinking.

KW - Adult

KW - Alcohol Drinking

KW - Alcoholism

KW - Databases, Factual

KW - Denmark

KW - Female

KW - Hospitals, University

KW - Humans

KW - Logistic Models

KW - Longitudinal Studies

KW - Male

KW - Middle Aged

KW - Pregnancy

KW - Premature Birth

KW - Registries

KW - Risk Factors

KW - Sex Factors

M3 - Journal article

C2 - 21513675

SN - 1937-1888

VL - 72

SP - 390

EP - 398

JO - Journal of Studies on Alcohol and Drugs

JF - Journal of Studies on Alcohol and Drugs

IS - 3

ER -

Effects of premature birth on the risk for alcoholism appear to be greater in males than females

Abstract

Keywords

UN SDGs

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