Effects of physical training on endothelial function and limb blood flow in type 2 diabetes.

TY - JOUR

T1 - Effects of physical training on endothelial function and limb blood flow in type 2 diabetes.

AU - Sonne, Mette Paulli

AU - Scheede-Bergdahl, Celena

AU - Olsen, David Benee

AU - Højbjerre, Lise

AU - Alibegovic, Amra

AU - Nielsen, Ninna Bo

AU - Stallknecht, Bente

AU - Helge, Jørn Wulff

AU - Vaag, Allan

AU - Dela, Flemming

N1 - Keywords: Diabetes Mellitus, Type 2; Endothelium, Vascular; Exercise; Humans; Leg; Vasodilation

PY - 2007

Y1 - 2007

N2 - The term "endothelial dysfunction" refers to the inability or attenuated effect of the endothelial cells in participating in the relaxation of the adjacent smooth muscle, thus causing less vasodilation. Although endothelial dysfunction is often seen in patients with type 2 diabetes, it does not necessarily follow that insulin resistance and (or) hyperglycemia is causing the inability to respond properly to vasodilatory stimuli. Rather, this could be related to the impact of concomitant cardiovascular risk factors that are almost invariably present in patients with type 2 diabetes. The impact of physical training - or the opposite, inactivity - on endothelial function is not fully elucidated. Some studies have shown positive effects of physical training, whereas others have not. In general, physical training can improve endothelial function when this is impaired. However, physical training does not seem to have any effect on endothelial function when this is normal.

AB - The term "endothelial dysfunction" refers to the inability or attenuated effect of the endothelial cells in participating in the relaxation of the adjacent smooth muscle, thus causing less vasodilation. Although endothelial dysfunction is often seen in patients with type 2 diabetes, it does not necessarily follow that insulin resistance and (or) hyperglycemia is causing the inability to respond properly to vasodilatory stimuli. Rather, this could be related to the impact of concomitant cardiovascular risk factors that are almost invariably present in patients with type 2 diabetes. The impact of physical training - or the opposite, inactivity - on endothelial function is not fully elucidated. Some studies have shown positive effects of physical training, whereas others have not. In general, physical training can improve endothelial function when this is impaired. However, physical training does not seem to have any effect on endothelial function when this is normal.

U2 - 10.1139/h07-103

DO - 10.1139/h07-103

M3 - Journal article

C2 - 18059619

SN - 1715-5312

VL - 32

SP - 936

EP - 941

JO - Applied Physiology, Nutrition and Metabolism

JF - Applied Physiology, Nutrition and Metabolism

IS - 5

ER -