Effects of exercise and diet in nonobese asthma patients - a randomized controlled trial

Louise Lindhardt Tønnesen; Howraman Meteran; Morten Hostrup; Nina Rica Wium Geiker; Camilla Bjørn Jensen; Celeste Porsbjerg; Arne Astrup; Jens Bangsbo; Debbie Parker; Vibeke Backer

doi:10.1016/j.jaip.2017.09.028

Effects of exercise and diet in nonobese asthma patients - a randomized controlled trial

Louise Lindhardt Tønnesen, Howraman Meteran, Morten Hostrup, Nina Rica Wium Geiker, Camilla Bjørn Jensen, Celeste Porsbjerg, Arne Astrup, Jens Bangsbo, Debbie Parker, Vibeke Backer

27 Citations (Scopus)

Abstract

Background: Behavioral interventions focusing on exercise and healthy diet improve asthma control in obese patients with asthma, but whether these interventions can lead to improvements in nonobese patients remains unclear. Objectives: In a randomized, controlled parallel-group design, we studied the effects of an 8-week intervention of either exercise (high-intensity interval training), diet (high protein/low glycemic index), or a combination of the 2, on asthma control and clinical outcomes in nonobese patients with asthma. Methods: Nonobese adult patients with asthma (n = 149) were randomized to 1 of 4 groups: an exercise group, a diet group, an exercise + diet group, or a control group. Outcomes included Asthma Control Questionnaire (ACQ) score, asthma-related quality-of-life (Asthma-Related Quality-of-Life Questionnaire [AQLQ]) score, inflammatory cell counts in induced sputum, FEV₁, fractional exhaled nitric oxide, and airway hyperresponsiveness (AHR). Results: A total of 125 patients completed the study and were included in the data analysis. Patients in the exercise + diet group improved the ACQ score from 1.9 ± 0.7 to 1.0 ± 0.7 and the AQLQ score from 5.2 ± 0.8 to 6.2 ± 0.7, which was statistically significant when compared with changes in the control group (P < .05 and <.01, respectively). The exercise group and the diet group did not improve either the ACQ score or the AQLQ score significantly compared with the control group and there were no significant changes in sputum cell counts, FEV₁, fractional exhaled nitric oxide, or AHR within any groups following the intervention period. Conclusions: The combination of exercise and diet improves asthma control in nonobese patients, but does not affect AHR or airway inflammation.

Original language	English
Journal	Journal of Allergy and Clinical Immunology: In Practice
Volume	6
Issue number	3
Pages (from-to)	803-811
Number of pages	9
ISSN	2213-2198
DOIs	https://doi.org/10.1016/j.jaip.2017.09.028
Publication status	Published - 1 May 2018

Keywords

Obstructive airway disease
Clinical trial
Diet therapy
High-intensity interval training

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10.1016/j.jaip.2017.09.028

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title = "Effects of exercise and diet in nonobese asthma patients - a randomized controlled trial",

abstract = "Background: Behavioral interventions focusing on exercise and healthy diet improve asthma control in obese patients with asthma, but whether these interventions can lead to improvements in nonobese patients remains unclear. Objectives: In a randomized, controlled parallel-group design, we studied the effects of an 8-week intervention of either exercise (high-intensity interval training), diet (high protein/low glycemic index), or a combination of the 2, on asthma control and clinical outcomes in nonobese patients with asthma. Methods: Nonobese adult patients with asthma (n = 149) were randomized to 1 of 4 groups: an exercise group, a diet group, an exercise + diet group, or a control group. Outcomes included Asthma Control Questionnaire (ACQ) score, asthma-related quality-of-life (Asthma-Related Quality-of-Life Questionnaire [AQLQ]) score, inflammatory cell counts in induced sputum, FEV1, fractional exhaled nitric oxide, and airway hyperresponsiveness (AHR). Results: A total of 125 patients completed the study and were included in the data analysis. Patients in the exercise + diet group improved the ACQ score from 1.9 ± 0.7 to 1.0 ± 0.7 and the AQLQ score from 5.2 ± 0.8 to 6.2 ± 0.7, which was statistically significant when compared with changes in the control group (P < .05 and <.01, respectively). The exercise group and the diet group did not improve either the ACQ score or the AQLQ score significantly compared with the control group and there were no significant changes in sputum cell counts, FEV1, fractional exhaled nitric oxide, or AHR within any groups following the intervention period. Conclusions: The combination of exercise and diet improves asthma control in nonobese patients, but does not affect AHR or airway inflammation.",

keywords = "Obstructive airway disease, Clinical trial, Diet therapy, High-intensity interval training",

author = "T{\o}nnesen, {Louise Lindhardt} and Howraman Meteran and Morten Hostrup and Geiker, {Nina Rica Wium} and Jensen, {Camilla Bj{\o}rn} and Celeste Porsbjerg and Arne Astrup and Jens Bangsbo and Debbie Parker and Vibeke Backer",

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doi = "10.1016/j.jaip.2017.09.028",

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TY - JOUR

T1 - Effects of exercise and diet in nonobese asthma patients - a randomized controlled trial

AU - Tønnesen, Louise Lindhardt

AU - Meteran, Howraman

AU - Hostrup, Morten

AU - Geiker, Nina Rica Wium

AU - Jensen, Camilla Bjørn

AU - Porsbjerg, Celeste

AU - Astrup, Arne

AU - Bangsbo, Jens

AU - Parker, Debbie

AU - Backer, Vibeke

N1 - CURIS 2018 NEXS 160

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Background: Behavioral interventions focusing on exercise and healthy diet improve asthma control in obese patients with asthma, but whether these interventions can lead to improvements in nonobese patients remains unclear. Objectives: In a randomized, controlled parallel-group design, we studied the effects of an 8-week intervention of either exercise (high-intensity interval training), diet (high protein/low glycemic index), or a combination of the 2, on asthma control and clinical outcomes in nonobese patients with asthma. Methods: Nonobese adult patients with asthma (n = 149) were randomized to 1 of 4 groups: an exercise group, a diet group, an exercise + diet group, or a control group. Outcomes included Asthma Control Questionnaire (ACQ) score, asthma-related quality-of-life (Asthma-Related Quality-of-Life Questionnaire [AQLQ]) score, inflammatory cell counts in induced sputum, FEV1, fractional exhaled nitric oxide, and airway hyperresponsiveness (AHR). Results: A total of 125 patients completed the study and were included in the data analysis. Patients in the exercise + diet group improved the ACQ score from 1.9 ± 0.7 to 1.0 ± 0.7 and the AQLQ score from 5.2 ± 0.8 to 6.2 ± 0.7, which was statistically significant when compared with changes in the control group (P < .05 and <.01, respectively). The exercise group and the diet group did not improve either the ACQ score or the AQLQ score significantly compared with the control group and there were no significant changes in sputum cell counts, FEV1, fractional exhaled nitric oxide, or AHR within any groups following the intervention period. Conclusions: The combination of exercise and diet improves asthma control in nonobese patients, but does not affect AHR or airway inflammation.

AB - Background: Behavioral interventions focusing on exercise and healthy diet improve asthma control in obese patients with asthma, but whether these interventions can lead to improvements in nonobese patients remains unclear. Objectives: In a randomized, controlled parallel-group design, we studied the effects of an 8-week intervention of either exercise (high-intensity interval training), diet (high protein/low glycemic index), or a combination of the 2, on asthma control and clinical outcomes in nonobese patients with asthma. Methods: Nonobese adult patients with asthma (n = 149) were randomized to 1 of 4 groups: an exercise group, a diet group, an exercise + diet group, or a control group. Outcomes included Asthma Control Questionnaire (ACQ) score, asthma-related quality-of-life (Asthma-Related Quality-of-Life Questionnaire [AQLQ]) score, inflammatory cell counts in induced sputum, FEV1, fractional exhaled nitric oxide, and airway hyperresponsiveness (AHR). Results: A total of 125 patients completed the study and were included in the data analysis. Patients in the exercise + diet group improved the ACQ score from 1.9 ± 0.7 to 1.0 ± 0.7 and the AQLQ score from 5.2 ± 0.8 to 6.2 ± 0.7, which was statistically significant when compared with changes in the control group (P < .05 and <.01, respectively). The exercise group and the diet group did not improve either the ACQ score or the AQLQ score significantly compared with the control group and there were no significant changes in sputum cell counts, FEV1, fractional exhaled nitric oxide, or AHR within any groups following the intervention period. Conclusions: The combination of exercise and diet improves asthma control in nonobese patients, but does not affect AHR or airway inflammation.

KW - Obstructive airway disease

KW - Clinical trial

KW - Diet therapy

KW - High-intensity interval training

U2 - 10.1016/j.jaip.2017.09.028

DO - 10.1016/j.jaip.2017.09.028

M3 - Journal article

C2 - 29133220

SN - 2213-2198

VL - 6

SP - 803

EP - 811

JO - The Journal of Allergy and Clinical Immunology: In Practice

JF - The Journal of Allergy and Clinical Immunology: In Practice

IS - 3

ER -

Effects of exercise and diet in nonobese asthma patients - a randomized controlled trial

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Keywords

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