Effects of cognitive therapy versus interpersonal psychotherapy in patients with major depressive disorder: a systematic review of randomized clinical trials with meta-analyses and trial sequential analyses

Janus Christian Jakobsen; J L Hansen; Sebastian Simonsen; Erik Simonsen; Christian Gluud

doi:10.1017/s0033291711002236

Effects of cognitive therapy versus interpersonal psychotherapy in patients with major depressive disorder: a systematic review of randomized clinical trials with meta-analyses and trial sequential analyses

Janus Christian Jakobsen, J L Hansen, Sebastian Simonsen, Erik Simonsen, Christian Gluud

Department of Clinical Medicine

39 Citations (Scopus)

Abstract

Background Major depressive disorder afflicts an estimated 17% of individuals during their lifetime at tremendous suffering and cost. Cognitive therapy and interpersonal psychotherapy are treatment options, but their effects have only been limitedly compared in systematic reviews.Method Using Cochrane systematic review methodology we compared the benefits and harm of cognitive therapy versus interpersonal psychotherapy for major depressive disorder. Trials were identified by searching the Cochrane Library's CENTRAL, Medline via PubMed, EMBASE, Psychlit, PsycInfo, and Science Citation Index Expanded until February 2010. Continuous outcome measures were assessed by mean difference and dichotomous outcomes by odds ratio. We conducted trial sequential analysis to control for random errors.Results We included seven trials randomizing 741 participants. All trials had high risk of bias. Meta-analysis of the four trials reporting data at cessation of treatment on the Hamilton Rating Scale for Depression showed no significant difference between the two interventions [mean difference â̂'1.02, 95% confidence interval (CI) â̂'2.35 to 0.32]. Meta-analysis of the five trials reporting data at cessation of treatment on the Beck Depression Inventory showed comparable results (mean difference â̂'1.29, 95% CI â̂'2.73 to 0.14). Trial sequential analysis indicated that more data are needed to definitively settle the question of a differential effect. None of the included trial reported on adverse events.Conclusions Randomized trials with low risk of bias and low risk of random errors are needed, although the effects of cognitive therapy and interpersonal psychotherapy do not seem to differ significantly regarding depressive symptoms. Future trials should report on adverse events.

Original language	English
Journal	Psychological Medicine
Volume	42
Issue number	7
Pages (from-to)	1343-57
Number of pages	15
ISSN	0033-2917
DOIs	https://doi.org/10.1017/s0033291711002236
Publication status	Published - Jul 2012

Keywords

Bias (Epidemiology)
Cognitive Therapy
Depressive Disorder, Major
Female
Humans
Interpersonal Relations
Male
Outcome Assessment (Health Care)
Psychiatric Status Rating Scales
Psychotherapy
Randomized Controlled Trials as Topic
Research Design
Comparative Study
Journal Article
Meta-Analysis
Review

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Effects of cognitive therapy versus interpersonal psychotherapy in patients with major depressive disorder : a systematic review of randomized clinical trials with meta-analyses and trial sequential analyses. / Jakobsen, Janus Christian; Hansen, J L; Simonsen, Sebastian et al.

In: Psychological Medicine, Vol. 42, No. 7, 07.2012, p. 1343-57.

Research output: Contribution to journal › Journal article › Research › peer-review

Jakobsen, JC, Hansen, JL, Simonsen, S, Simonsen, E & Gluud, C 2012, 'Effects of cognitive therapy versus interpersonal psychotherapy in patients with major depressive disorder: a systematic review of randomized clinical trials with meta-analyses and trial sequential analyses', Psychological Medicine, vol. 42, no. 7, pp. 1343-57. https://doi.org/10.1017/s0033291711002236

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title = "Effects of cognitive therapy versus interpersonal psychotherapy in patients with major depressive disorder: a systematic review of randomized clinical trials with meta-analyses and trial sequential analyses",

abstract = "Background Major depressive disorder afflicts an estimated 17% of individuals during their lifetime at tremendous suffering and cost. Cognitive therapy and interpersonal psychotherapy are treatment options, but their effects have only been limitedly compared in systematic reviews.Method Using Cochrane systematic review methodology we compared the benefits and harm of cognitive therapy versus interpersonal psychotherapy for major depressive disorder. Trials were identified by searching the Cochrane Library's CENTRAL, Medline via PubMed, EMBASE, Psychlit, PsycInfo, and Science Citation Index Expanded until February 2010. Continuous outcome measures were assessed by mean difference and dichotomous outcomes by odds ratio. We conducted trial sequential analysis to control for random errors.Results We included seven trials randomizing 741 participants. All trials had high risk of bias. Meta-analysis of the four trials reporting data at cessation of treatment on the Hamilton Rating Scale for Depression showed no significant difference between the two interventions [mean difference {\^a}̂'1.02, 95% confidence interval (CI) {\^a}̂'2.35 to 0.32]. Meta-analysis of the five trials reporting data at cessation of treatment on the Beck Depression Inventory showed comparable results (mean difference {\^a}̂'1.29, 95% CI {\^a}̂'2.73 to 0.14). Trial sequential analysis indicated that more data are needed to definitively settle the question of a differential effect. None of the included trial reported on adverse events.Conclusions Randomized trials with low risk of bias and low risk of random errors are needed, although the effects of cognitive therapy and interpersonal psychotherapy do not seem to differ significantly regarding depressive symptoms. Future trials should report on adverse events.",

keywords = "Bias (Epidemiology), Cognitive Therapy, Depressive Disorder, Major, Female, Humans, Interpersonal Relations, Male, Outcome Assessment (Health Care), Psychiatric Status Rating Scales, Psychotherapy, Randomized Controlled Trials as Topic, Research Design, Comparative Study, Journal Article, Meta-Analysis, Review",

author = "Jakobsen, {Janus Christian} and Hansen, {J L} and Sebastian Simonsen and Erik Simonsen and Christian Gluud",

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T1 - Effects of cognitive therapy versus interpersonal psychotherapy in patients with major depressive disorder

T2 - a systematic review of randomized clinical trials with meta-analyses and trial sequential analyses

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AU - Hansen, J L

AU - Simonsen, Sebastian

AU - Simonsen, Erik

AU - Gluud, Christian

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N2 - Background Major depressive disorder afflicts an estimated 17% of individuals during their lifetime at tremendous suffering and cost. Cognitive therapy and interpersonal psychotherapy are treatment options, but their effects have only been limitedly compared in systematic reviews.Method Using Cochrane systematic review methodology we compared the benefits and harm of cognitive therapy versus interpersonal psychotherapy for major depressive disorder. Trials were identified by searching the Cochrane Library's CENTRAL, Medline via PubMed, EMBASE, Psychlit, PsycInfo, and Science Citation Index Expanded until February 2010. Continuous outcome measures were assessed by mean difference and dichotomous outcomes by odds ratio. We conducted trial sequential analysis to control for random errors.Results We included seven trials randomizing 741 participants. All trials had high risk of bias. Meta-analysis of the four trials reporting data at cessation of treatment on the Hamilton Rating Scale for Depression showed no significant difference between the two interventions [mean difference â̂'1.02, 95% confidence interval (CI) â̂'2.35 to 0.32]. Meta-analysis of the five trials reporting data at cessation of treatment on the Beck Depression Inventory showed comparable results (mean difference â̂'1.29, 95% CI â̂'2.73 to 0.14). Trial sequential analysis indicated that more data are needed to definitively settle the question of a differential effect. None of the included trial reported on adverse events.Conclusions Randomized trials with low risk of bias and low risk of random errors are needed, although the effects of cognitive therapy and interpersonal psychotherapy do not seem to differ significantly regarding depressive symptoms. Future trials should report on adverse events.

AB - Background Major depressive disorder afflicts an estimated 17% of individuals during their lifetime at tremendous suffering and cost. Cognitive therapy and interpersonal psychotherapy are treatment options, but their effects have only been limitedly compared in systematic reviews.Method Using Cochrane systematic review methodology we compared the benefits and harm of cognitive therapy versus interpersonal psychotherapy for major depressive disorder. Trials were identified by searching the Cochrane Library's CENTRAL, Medline via PubMed, EMBASE, Psychlit, PsycInfo, and Science Citation Index Expanded until February 2010. Continuous outcome measures were assessed by mean difference and dichotomous outcomes by odds ratio. We conducted trial sequential analysis to control for random errors.Results We included seven trials randomizing 741 participants. All trials had high risk of bias. Meta-analysis of the four trials reporting data at cessation of treatment on the Hamilton Rating Scale for Depression showed no significant difference between the two interventions [mean difference â̂'1.02, 95% confidence interval (CI) â̂'2.35 to 0.32]. Meta-analysis of the five trials reporting data at cessation of treatment on the Beck Depression Inventory showed comparable results (mean difference â̂'1.29, 95% CI â̂'2.73 to 0.14). Trial sequential analysis indicated that more data are needed to definitively settle the question of a differential effect. None of the included trial reported on adverse events.Conclusions Randomized trials with low risk of bias and low risk of random errors are needed, although the effects of cognitive therapy and interpersonal psychotherapy do not seem to differ significantly regarding depressive symptoms. Future trials should report on adverse events.

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KW - Cognitive Therapy

KW - Depressive Disorder, Major

KW - Female

KW - Humans

KW - Interpersonal Relations

KW - Male

KW - Outcome Assessment (Health Care)

KW - Psychiatric Status Rating Scales

KW - Psychotherapy

KW - Randomized Controlled Trials as Topic

KW - Research Design

KW - Comparative Study

KW - Journal Article

KW - Meta-Analysis

KW - Review

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DO - 10.1017/s0033291711002236

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C2 - 22051174

SN - 0033-2917

VL - 42

SP - 1343

EP - 1357

JO - Psychological Medicine

JF - Psychological Medicine

IS - 7

ER -