Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome - a randomized study (SYSDIET)

M Uusitupa; Kjeld Hermansen; M J Savolainen; U Schwab; M Kolehmainen; Lea Johanne Brader; L S Mortensen; L Cloetens; A Johansson-Persson; G Önning; M Landin-Olsson; K-H Herzig; J Hukkanen; F Rosqvist; D Iggman; J Paananen; K J Pulkki; M Siloaho; Lars Ove Dragsted; T Barri; K Overvad; K E Bach Knudsen; Mette Skou Hedemann; P Arner; I Dahlman; G I A Borge; P Baardseth; S M Ulven; I Gunnarsdottir; Sigrun Jónsdóttir; I Thorsdottir; M Orešic; K S Poutanen; U Risérus; B Åkesson

doi:10.1111/joim.12044

Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome - a randomized study (SYSDIET)

M Uusitupa, Kjeld Hermansen, M J Savolainen, U Schwab, M Kolehmainen, Lea Johanne Brader, L S Mortensen, L Cloetens, A Johansson-Persson, G Önning, M Landin-Olsson, K-H Herzig, J Hukkanen, F Rosqvist, D Iggman, J Paananen, K J Pulkki, M Siloaho, Lars Ove Dragsted, T BarriK Overvad, K E Bach Knudsen, Mette Skou Hedemann, P Arner, I Dahlman, G I A Borge, P Baardseth, S M Ulven, I Gunnarsdottir, Sigrun Jónsdóttir, I Thorsdottir, M Orešic, K S Poutanen, U Risérus, B Åkesson

Department of Nutrition, Exercise and Sports

157 Citations (Scopus)

Abstract

BACKGROUND: Different healthy food patterns may modify cardiometabolic risk. We investigated the effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile, blood pressure and inflammatory markers in people with metabolic syndrome. METHODS: We conducted a randomized dietary study lasting for 18-24 weeks in individuals with features of metabolic syndrome (mean age 55 years, BMI 31.6 kg m-2 , 67% women). Altogether 309 individuals were screened, 200 started the intervention after 4-week run-in period, and 96 (proportion of dropouts 7.9%) and 70 individuals (dropouts 27%) completed the study, in the Healthy diet and Control diet groups, respectively. Healthy diet included whole-grain products, berries, fruits and vegetables, rapeseed oil, three fish meals per week and low-fat dairy products. An average Nordic diet served as a Control diet. Compliance was monitored by repeated 4-day food diaries and fatty acid composition of serum phospholipids. RESULTS: Body weight remained stable, and no significant changes were observed in insulin sensitivity or blood pressure. Significant changes between the groups were found in non-HDL cholesterol (-0.18, mmol L-1 95% CI -0.35; -0.01, P = 0.04), LDL to HDL cholesterol (-0.15, -0.28; -0.00, P = 0.046) and apolipoprotein B to apolipoprotein A1 ratios (-0.04, -0.07; -0.00, P = 0.025) favouring the Healthy diet. IL-1 Ra increased during the Control diet (difference -84, -133; -37 ng L-1 , P = 0.00053). Intakes of saturated fats (E%, beta estimate 4.28, 0.02; 8.53, P = 0.049) and magnesium (mg, -0.23, -0.41; -0.05, P = 0.012) were associated with IL-1 Ra. CONCLUSIONS: Healthy Nordic diet improved lipid profile and had a beneficial effect on low-grade inflammation.

Original language	English
Journal	Journal of Internal Medicine
Volume	274
Issue number	1
Pages (from-to)	52-66
Number of pages	15
ISSN	0954-6820
DOIs	https://doi.org/10.1111/joim.12044
Publication status	Published - 1 Jul 2013

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Uusitupa, M., Hermansen, K., Savolainen, M. J., Schwab, U., Kolehmainen, M., Brader, L. J., Mortensen, L. S., Cloetens, L., Johansson-Persson, A., Önning, G., Landin-Olsson, M., Herzig, K-H., Hukkanen, J., Rosqvist, F., Iggman, D., Paananen, J., Pulkki, K. J., Siloaho, M., Dragsted, L. O., ... Åkesson, B. (2013). Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome - a randomized study (SYSDIET). Journal of Internal Medicine, 274(1), 52-66. https://doi.org/10.1111/joim.12044

Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome - a randomized study (SYSDIET). / Uusitupa, M; Hermansen, Kjeld; Savolainen, M J et al.

In: Journal of Internal Medicine, Vol. 274, No. 1, 01.07.2013, p. 52-66.

Research output: Contribution to journal › Journal article › Research › peer-review

Uusitupa, M, Hermansen, K, Savolainen, MJ, Schwab, U, Kolehmainen, M, Brader, LJ, Mortensen, LS, Cloetens, L, Johansson-Persson, A, Önning, G, Landin-Olsson, M, Herzig, K-H, Hukkanen, J, Rosqvist, F, Iggman, D, Paananen, J, Pulkki, KJ, Siloaho, M, Dragsted, LO, Barri, T, Overvad, K, Bach Knudsen, KE, Hedemann, MS, Arner, P, Dahlman, I, Borge, GIA, Baardseth, P, Ulven, SM, Gunnarsdottir, I, Jónsdóttir, S, Thorsdottir, I, Orešic, M, Poutanen, KS, Risérus, U & Åkesson, B 2013, 'Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome - a randomized study (SYSDIET)', Journal of Internal Medicine, vol. 274, no. 1, pp. 52-66. https://doi.org/10.1111/joim.12044

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title = "Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome - a randomized study (SYSDIET)",

abstract = "BACKGROUND: Different healthy food patterns may modify cardiometabolic risk. We investigated the effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile, blood pressure and inflammatory markers in people with metabolic syndrome. METHODS: We conducted a randomized dietary study lasting for 18-24 weeks in individuals with features of metabolic syndrome (mean age 55 years, BMI 31.6 kg m-2 , 67% women). Altogether 309 individuals were screened, 200 started the intervention after 4-week run-in period, and 96 (proportion of dropouts 7.9%) and 70 individuals (dropouts 27%) completed the study, in the Healthy diet and Control diet groups, respectively. Healthy diet included whole-grain products, berries, fruits and vegetables, rapeseed oil, three fish meals per week and low-fat dairy products. An average Nordic diet served as a Control diet. Compliance was monitored by repeated 4-day food diaries and fatty acid composition of serum phospholipids. RESULTS: Body weight remained stable, and no significant changes were observed in insulin sensitivity or blood pressure. Significant changes between the groups were found in non-HDL cholesterol (-0.18, mmol L-1 95% CI -0.35; -0.01, P = 0.04), LDL to HDL cholesterol (-0.15, -0.28; -0.00, P = 0.046) and apolipoprotein B to apolipoprotein A1 ratios (-0.04, -0.07; -0.00, P = 0.025) favouring the Healthy diet. IL-1 Ra increased during the Control diet (difference -84, -133; -37 ng L-1 , P = 0.00053). Intakes of saturated fats (E%, beta estimate 4.28, 0.02; 8.53, P = 0.049) and magnesium (mg, -0.23, -0.41; -0.05, P = 0.012) were associated with IL-1 Ra. CONCLUSIONS: Healthy Nordic diet improved lipid profile and had a beneficial effect on low-grade inflammation.",

author = "M Uusitupa and Kjeld Hermansen and Savolainen, {M J} and U Schwab and M Kolehmainen and Brader, {Lea Johanne} and Mortensen, {L S} and L Cloetens and A Johansson-Persson and G {\"O}nning and M Landin-Olsson and K-H Herzig and J Hukkanen and F Rosqvist and D Iggman and J Paananen and Pulkki, {K J} and M Siloaho and Dragsted, {Lars Ove} and T Barri and K Overvad and {Bach Knudsen}, {K E} and Hedemann, {Mette Skou} and P Arner and I Dahlman and Borge, {G I A} and P Baardseth and Ulven, {S M} and I Gunnarsdottir and Sigrun J{\'o}nsd{\'o}ttir and I Thorsdottir and M Ore{\v s}ic and Poutanen, {K S} and U Ris{\'e}rus and B {\AA}kesson",

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T1 - Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome - a randomized study (SYSDIET)

AU - Uusitupa, M

AU - Hermansen, Kjeld

AU - Savolainen, M J

AU - Schwab, U

AU - Kolehmainen, M

AU - Brader, Lea Johanne

AU - Mortensen, L S

AU - Cloetens, L

AU - Johansson-Persson, A

AU - Önning, G

AU - Landin-Olsson, M

AU - Herzig, K-H

AU - Hukkanen, J

AU - Rosqvist, F

AU - Iggman, D

AU - Paananen, J

AU - Pulkki, K J

AU - Siloaho, M

AU - Dragsted, Lars Ove

AU - Barri, T

AU - Overvad, K

AU - Bach Knudsen, K E

AU - Hedemann, Mette Skou

AU - Arner, P

AU - Dahlman, I

AU - Borge, G I A

AU - Baardseth, P

AU - Ulven, S M

AU - Gunnarsdottir, I

AU - Jónsdóttir, Sigrun

AU - Thorsdottir, I

AU - Orešic, M

AU - Poutanen, K S

AU - Risérus, U

AU - Åkesson, B

N1 - CURIS 2013 NEXS 049

PY - 2013/7/1

Y1 - 2013/7/1

N2 - BACKGROUND: Different healthy food patterns may modify cardiometabolic risk. We investigated the effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile, blood pressure and inflammatory markers in people with metabolic syndrome. METHODS: We conducted a randomized dietary study lasting for 18-24 weeks in individuals with features of metabolic syndrome (mean age 55 years, BMI 31.6 kg m-2 , 67% women). Altogether 309 individuals were screened, 200 started the intervention after 4-week run-in period, and 96 (proportion of dropouts 7.9%) and 70 individuals (dropouts 27%) completed the study, in the Healthy diet and Control diet groups, respectively. Healthy diet included whole-grain products, berries, fruits and vegetables, rapeseed oil, three fish meals per week and low-fat dairy products. An average Nordic diet served as a Control diet. Compliance was monitored by repeated 4-day food diaries and fatty acid composition of serum phospholipids. RESULTS: Body weight remained stable, and no significant changes were observed in insulin sensitivity or blood pressure. Significant changes between the groups were found in non-HDL cholesterol (-0.18, mmol L-1 95% CI -0.35; -0.01, P = 0.04), LDL to HDL cholesterol (-0.15, -0.28; -0.00, P = 0.046) and apolipoprotein B to apolipoprotein A1 ratios (-0.04, -0.07; -0.00, P = 0.025) favouring the Healthy diet. IL-1 Ra increased during the Control diet (difference -84, -133; -37 ng L-1 , P = 0.00053). Intakes of saturated fats (E%, beta estimate 4.28, 0.02; 8.53, P = 0.049) and magnesium (mg, -0.23, -0.41; -0.05, P = 0.012) were associated with IL-1 Ra. CONCLUSIONS: Healthy Nordic diet improved lipid profile and had a beneficial effect on low-grade inflammation.

AB - BACKGROUND: Different healthy food patterns may modify cardiometabolic risk. We investigated the effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile, blood pressure and inflammatory markers in people with metabolic syndrome. METHODS: We conducted a randomized dietary study lasting for 18-24 weeks in individuals with features of metabolic syndrome (mean age 55 years, BMI 31.6 kg m-2 , 67% women). Altogether 309 individuals were screened, 200 started the intervention after 4-week run-in period, and 96 (proportion of dropouts 7.9%) and 70 individuals (dropouts 27%) completed the study, in the Healthy diet and Control diet groups, respectively. Healthy diet included whole-grain products, berries, fruits and vegetables, rapeseed oil, three fish meals per week and low-fat dairy products. An average Nordic diet served as a Control diet. Compliance was monitored by repeated 4-day food diaries and fatty acid composition of serum phospholipids. RESULTS: Body weight remained stable, and no significant changes were observed in insulin sensitivity or blood pressure. Significant changes between the groups were found in non-HDL cholesterol (-0.18, mmol L-1 95% CI -0.35; -0.01, P = 0.04), LDL to HDL cholesterol (-0.15, -0.28; -0.00, P = 0.046) and apolipoprotein B to apolipoprotein A1 ratios (-0.04, -0.07; -0.00, P = 0.025) favouring the Healthy diet. IL-1 Ra increased during the Control diet (difference -84, -133; -37 ng L-1 , P = 0.00053). Intakes of saturated fats (E%, beta estimate 4.28, 0.02; 8.53, P = 0.049) and magnesium (mg, -0.23, -0.41; -0.05, P = 0.012) were associated with IL-1 Ra. CONCLUSIONS: Healthy Nordic diet improved lipid profile and had a beneficial effect on low-grade inflammation.

U2 - 10.1111/joim.12044

DO - 10.1111/joim.12044

M3 - Journal article

C2 - 23398528

SN - 0955-7873

VL - 274

SP - 52

EP - 66

JO - Acta Medica Scandinavica

JF - Acta Medica Scandinavica

IS - 1

ER -

Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome - a randomized study (SYSDIET)

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