Effect of vaccination against sub-clinical Porcine Circovirus type 2 infection in a high-health finishing pig herd: A randomised clinical field trial

Gitte Blach Nielsen; Jens Peter Nielsen; John Haugegaard; Matthew J. Denwood; Hans Houe

doi:10.1016/j.prevetmed.2017.04.003

Effect of vaccination against sub-clinical Porcine Circovirus type 2 infection in a high-health finishing pig herd: A randomised clinical field trial

Gitte Blach Nielsen^*, Jens Peter Nielsen, John Haugegaard, Matthew J. Denwood, Hans Houe

^*Corresponding author for this work

5 Citations (Scopus)

Abstract

During the last decade, the clinical manifestation of Porcine Circovirus type 2 (PCV2) infections has mostly changed from postweaning multisystemic wasting syndrome and high mortality to sub-clinical infections manifested only through impaired production parameters. However, co-infection with other respiratory pathogens often results in a larger effect on production, sometimes with clinical signs. Little is known about the impact of a moderate level PCV2 infection without co-infections, particularly in terms of feed conversion ratio and antimicrobial consumption. The purpose of the study was to evaluate the effect of vaccination against PCV2 in a sub-clinically infected, high-health finishing herd in terms of viral load in serum, feed conversion ratio and antimicrobial treatments. The study was conducted as a randomised clinical field trial with a parallel group design. Vaccination against PCV2 significantly (p < 0.001) reduced the prevalence of PCV2-positive serum pools, from 91% in the control group to 6% in the vaccinated group, as well as the viral load for positive pools from 5.79 to 3.99 log(10) copies per ml serum. Despite this, feed conversion ratio for the two groups were not significantly different with an average of 2.75 and 2.76 feeding units/kg gain for vaccinated and control pigs, respectively (p = 0.598). The proportion of pigs treated by injection with an antimicrobial was lower in the vaccinated group (4.4%) compared to the non-vaccinated group (5.6%), but the difference was not significant (p = 0.125). In conclusion, in this herd without respiratory co-infections and with moderate viral loads of PCV2, vaccination significantly reduced the prevalence and viral load of PCV2-positive pigs, but had no significant impact on feed conversion ratio or antimicrobial consumption.

Original language	English
Journal	Preventive Veterinary Medicine
Volume	141
Pages (from-to)	14-21
Number of pages	8
ISSN	0167-5877
DOIs	https://doi.org/10.1016/j.prevetmed.2017.04.003
Publication status	Published - 2017

Keywords

Antimicrobial treatment
Feed conversion ratio
Finishers
Porcine circovirus type 2
Vaccination
Viral load

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.prevetmed.2017.04.003

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Effect of vaccination against sub-clinical Porcine Circovirus type 2 infection in a high-health finishing pig herd: A randomised clinical field trial. / Nielsen, Gitte Blach; Nielsen, Jens Peter; Haugegaard, John et al.
In: Preventive Veterinary Medicine, Vol. 141, 2017, p. 14-21.

Research output: Contribution to journal › Journal article › Research › peer-review

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title = "Effect of vaccination against sub-clinical Porcine Circovirus type 2 infection in a high-health finishing pig herd: A randomised clinical field trial",

abstract = "During the last decade, the clinical manifestation of Porcine Circovirus type 2 (PCV2) infections has mostly changed from postweaning multisystemic wasting syndrome and high mortality to sub-clinical infections manifested only through impaired production parameters. However, co-infection with other respiratory pathogens often results in a larger effect on production, sometimes with clinical signs. Little is known about the impact of a moderate level PCV2 infection without co-infections, particularly in terms of feed conversion ratio and antimicrobial consumption. The purpose of the study was to evaluate the effect of vaccination against PCV2 in a sub-clinically infected, high-health finishing herd in terms of viral load in serum, feed conversion ratio and antimicrobial treatments. The study was conducted as a randomised clinical field trial with a parallel group design. Vaccination against PCV2 significantly (p < 0.001) reduced the prevalence of PCV2-positive serum pools, from 91% in the control group to 6% in the vaccinated group, as well as the viral load for positive pools from 5.79 to 3.99 log(10) copies per ml serum. Despite this, feed conversion ratio for the two groups were not significantly different with an average of 2.75 and 2.76 feeding units/kg gain for vaccinated and control pigs, respectively (p = 0.598). The proportion of pigs treated by injection with an antimicrobial was lower in the vaccinated group (4.4%) compared to the non-vaccinated group (5.6%), but the difference was not significant (p = 0.125). In conclusion, in this herd without respiratory co-infections and with moderate viral loads of PCV2, vaccination significantly reduced the prevalence and viral load of PCV2-positive pigs, but had no significant impact on feed conversion ratio or antimicrobial consumption.",

keywords = "Antimicrobial treatment, Feed conversion ratio, Finishers, Porcine circovirus type 2, Vaccination, Viral load",

author = "Nielsen, {Gitte Blach} and Nielsen, {Jens Peter} and John Haugegaard and Denwood, {Matthew J.} and Hans Houe",

year = "2017",

doi = "10.1016/j.prevetmed.2017.04.003",

language = "English",

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pages = "14--21",

journal = "Preventive Veterinary Medicine",

issn = "0167-5877",

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T1 - Effect of vaccination against sub-clinical Porcine Circovirus type 2 infection in a high-health finishing pig herd

T2 - A randomised clinical field trial

AU - Nielsen, Gitte Blach

AU - Nielsen, Jens Peter

AU - Haugegaard, John

AU - Denwood, Matthew J.

AU - Houe, Hans

PY - 2017

Y1 - 2017

N2 - During the last decade, the clinical manifestation of Porcine Circovirus type 2 (PCV2) infections has mostly changed from postweaning multisystemic wasting syndrome and high mortality to sub-clinical infections manifested only through impaired production parameters. However, co-infection with other respiratory pathogens often results in a larger effect on production, sometimes with clinical signs. Little is known about the impact of a moderate level PCV2 infection without co-infections, particularly in terms of feed conversion ratio and antimicrobial consumption. The purpose of the study was to evaluate the effect of vaccination against PCV2 in a sub-clinically infected, high-health finishing herd in terms of viral load in serum, feed conversion ratio and antimicrobial treatments. The study was conducted as a randomised clinical field trial with a parallel group design. Vaccination against PCV2 significantly (p < 0.001) reduced the prevalence of PCV2-positive serum pools, from 91% in the control group to 6% in the vaccinated group, as well as the viral load for positive pools from 5.79 to 3.99 log(10) copies per ml serum. Despite this, feed conversion ratio for the two groups were not significantly different with an average of 2.75 and 2.76 feeding units/kg gain for vaccinated and control pigs, respectively (p = 0.598). The proportion of pigs treated by injection with an antimicrobial was lower in the vaccinated group (4.4%) compared to the non-vaccinated group (5.6%), but the difference was not significant (p = 0.125). In conclusion, in this herd without respiratory co-infections and with moderate viral loads of PCV2, vaccination significantly reduced the prevalence and viral load of PCV2-positive pigs, but had no significant impact on feed conversion ratio or antimicrobial consumption.

AB - During the last decade, the clinical manifestation of Porcine Circovirus type 2 (PCV2) infections has mostly changed from postweaning multisystemic wasting syndrome and high mortality to sub-clinical infections manifested only through impaired production parameters. However, co-infection with other respiratory pathogens often results in a larger effect on production, sometimes with clinical signs. Little is known about the impact of a moderate level PCV2 infection without co-infections, particularly in terms of feed conversion ratio and antimicrobial consumption. The purpose of the study was to evaluate the effect of vaccination against PCV2 in a sub-clinically infected, high-health finishing herd in terms of viral load in serum, feed conversion ratio and antimicrobial treatments. The study was conducted as a randomised clinical field trial with a parallel group design. Vaccination against PCV2 significantly (p < 0.001) reduced the prevalence of PCV2-positive serum pools, from 91% in the control group to 6% in the vaccinated group, as well as the viral load for positive pools from 5.79 to 3.99 log(10) copies per ml serum. Despite this, feed conversion ratio for the two groups were not significantly different with an average of 2.75 and 2.76 feeding units/kg gain for vaccinated and control pigs, respectively (p = 0.598). The proportion of pigs treated by injection with an antimicrobial was lower in the vaccinated group (4.4%) compared to the non-vaccinated group (5.6%), but the difference was not significant (p = 0.125). In conclusion, in this herd without respiratory co-infections and with moderate viral loads of PCV2, vaccination significantly reduced the prevalence and viral load of PCV2-positive pigs, but had no significant impact on feed conversion ratio or antimicrobial consumption.

KW - Antimicrobial treatment

KW - Feed conversion ratio

KW - Finishers

KW - Porcine circovirus type 2

KW - Vaccination

KW - Viral load

U2 - 10.1016/j.prevetmed.2017.04.003

DO - 10.1016/j.prevetmed.2017.04.003

M3 - Journal article

C2 - 28532989

AN - SCOPUS:85018638282

SN - 0167-5877

VL - 141

SP - 14

EP - 21

JO - Preventive Veterinary Medicine

JF - Preventive Veterinary Medicine

ER -

Effect of vaccination against sub-clinical Porcine Circovirus type 2 infection in a high-health finishing pig herd: A randomised clinical field trial

Abstract

Keywords

UN SDGs

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