Effect of simethicone on lactulose-induced H2 production and gastrointestinal symptoms

Henrik Friis; S Bodé; J J Rumessen; E Gudmand-Høyer

Effect of simethicone on lactulose-induced H2 production and gastrointestinal symptoms

Henrik Friis, S Bodé, J J Rumessen, E Gudmand-Høyer

Lifecourse Nutrition & Health

23 Citations (Scopus)

Abstract

The results of studies of the effect of simethicone on abdominal gas-related symptoms have been contradictory. In a randomized, double-blind cross-over study, 10 healthy volunteers were given 30 g lactulose and 600 mg simethicone or placebo. End-expiratory breath samples were collected and analyzed for H2 and gastrointestinal symptoms registered. There were no differences in biochemical parameters or symptom score between simethicone and placebo. In contrast to previous studies, we used a sufficiently large dose of lactulose to produce gastrointestinal symptoms, a higher dose of simethicone and placebo tablets containing the same additives as the simethicone tablets. There was no demonstrable effect of simethicone on symptoms or intestinal gas production caused by carbohydrate malabsorption.

Original language	English
Journal	Digestion
Volume	49
Issue number	4
Pages (from-to)	227-230
Number of pages	4
ISSN	0012-2823
Publication status	Published - 1991

Keywords

Adult
Breath Tests
Double-Blind Method
Female
Flatulence
Gastrointestinal Diseases
Humans
Hydrogen
Lactulose
Male
Simethicone

Cite this

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title = "Effect of simethicone on lactulose-induced H2 production and gastrointestinal symptoms",

abstract = "The results of studies of the effect of simethicone on abdominal gas-related symptoms have been contradictory. In a randomized, double-blind cross-over study, 10 healthy volunteers were given 30 g lactulose and 600 mg simethicone or placebo. End-expiratory breath samples were collected and analyzed for H2 and gastrointestinal symptoms registered. There were no differences in biochemical parameters or symptom score between simethicone and placebo. In contrast to previous studies, we used a sufficiently large dose of lactulose to produce gastrointestinal symptoms, a higher dose of simethicone and placebo tablets containing the same additives as the simethicone tablets. There was no demonstrable effect of simethicone on symptoms or intestinal gas production caused by carbohydrate malabsorption.",

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T1 - Effect of simethicone on lactulose-induced H2 production and gastrointestinal symptoms

AU - Friis, Henrik

AU - Bodé, S

AU - Rumessen, J J

AU - Gudmand-Høyer, E

PY - 1991

Y1 - 1991

N2 - The results of studies of the effect of simethicone on abdominal gas-related symptoms have been contradictory. In a randomized, double-blind cross-over study, 10 healthy volunteers were given 30 g lactulose and 600 mg simethicone or placebo. End-expiratory breath samples were collected and analyzed for H2 and gastrointestinal symptoms registered. There were no differences in biochemical parameters or symptom score between simethicone and placebo. In contrast to previous studies, we used a sufficiently large dose of lactulose to produce gastrointestinal symptoms, a higher dose of simethicone and placebo tablets containing the same additives as the simethicone tablets. There was no demonstrable effect of simethicone on symptoms or intestinal gas production caused by carbohydrate malabsorption.

AB - The results of studies of the effect of simethicone on abdominal gas-related symptoms have been contradictory. In a randomized, double-blind cross-over study, 10 healthy volunteers were given 30 g lactulose and 600 mg simethicone or placebo. End-expiratory breath samples were collected and analyzed for H2 and gastrointestinal symptoms registered. There were no differences in biochemical parameters or symptom score between simethicone and placebo. In contrast to previous studies, we used a sufficiently large dose of lactulose to produce gastrointestinal symptoms, a higher dose of simethicone and placebo tablets containing the same additives as the simethicone tablets. There was no demonstrable effect of simethicone on symptoms or intestinal gas production caused by carbohydrate malabsorption.

KW - Adult

KW - Breath Tests

KW - Double-Blind Method

KW - Female

KW - Flatulence

KW - Gastrointestinal Diseases

KW - Humans

KW - Hydrogen

KW - Lactulose

KW - Male

KW - Simethicone

M3 - Journal article

C2 - 1797602

SN - 0012-2823

VL - 49

SP - 227

EP - 230

JO - Digestion

JF - Digestion

IS - 4

ER -

Effect of simethicone on lactulose-induced H2 production and gastrointestinal symptoms

Abstract

Keywords

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