Effect of sex in the MRMT-1 model of cancer-induced bone pain

TY - JOUR

T1 - Effect of sex in the MRMT-1 model of cancer-induced bone pain

AU - Falk, Sarah

AU - Al-Dihaissy, Tamara

AU - Mezzanotte, Laura

AU - Heegaard, Anne-Marie

N1 - CURIS 2015 NEXS 426

PY - 2015

Y1 - 2015

N2 - An overwhelming amount of evidence demonstrates sex-induced variation in pain processing, and has thus increased the focus on sex as an essential parameter for optimization of in vivo models in pain research. Mammary cancer cells are often used to model metastatic bone pain in vivo, and are commonly used in both males and females. Here we demonstrate that compared to male rats, female rats have an increased capacity for recovery following inoculation of MRMT-1 mammary cells, thus potentially causing a sex-dependent bias in interpretation of the data.

AB - An overwhelming amount of evidence demonstrates sex-induced variation in pain processing, and has thus increased the focus on sex as an essential parameter for optimization of in vivo models in pain research. Mammary cancer cells are often used to model metastatic bone pain in vivo, and are commonly used in both males and females. Here we demonstrate that compared to male rats, female rats have an increased capacity for recovery following inoculation of MRMT-1 mammary cells, thus potentially causing a sex-dependent bias in interpretation of the data.

U2 - 10.12688/f1000research.6827.3

DO - 10.12688/f1000research.6827.3

M3 - Journal article

C2 - 26834983

SN - 2046-1402

VL - 4

SP - 1

EP - 18

JO - F1000Research

JF - F1000Research

IS - 445

M1 - 445

ER -