Abstract
In vitro studies have indicated that the antifolates pyrimethamine [4, 6] and cycloguanil (the active metabolite of proguanil) suppress the proliferation of stimulated human lymphocytes; proguanil has no effect [2]. During the early growth phase of the cells, 14C-thymidine (14C-TdR) incorporation is increased by pyrimethamine and cycloguanil, reflecting blockage of endogenous TdR synthesis [3]. Proguanil (Paludrine) is increasingly being used for malaria prophylaxis. It is considered the most innocuous of the antimalarials currently employed. Since nothing is known about the effect of oral proguanil on human lymphocytes, the present study was undertaken. Little information is available about the serum levels of proguanil and cycloguanil following ingestion of prophylactic doses [8]. Therefore, the serum concentrations of proguanil and cycloguanil were estimated, to allow comparison with previous in vitro studies [2].
| Original language | English |
|---|---|
| Journal | European Journal of Clinical Pharmacology |
| Volume | 30 |
| Issue number | 2 |
| Pages (from-to) | 249-51 |
| Number of pages | 3 |
| ISSN | 0031-6970 |
| Publication status | Published - 1 Jan 1986 |
Keywords
- Adult
- Humans
- Leukocyte Count
- Leukocytes
- Lymphocyte Activation
- Lymphocytes
- Phytohemagglutinins
- Proguanil
- Pyrimethamine
- Thymidine
- Time Factors
- Triazines
