TY - JOUR
T1 - Effect of milk proteins on linear growth and IGF variables in overweight adolescents
AU - Larnkjær, Anni
AU - Arnberg, Karina
AU - Michaelsen, Kim F
AU - Jensen, Signe Marie
AU - Mølgaard, Christian
N1 - CURIS 2014 NEXS 074
PY - 2014/4
Y1 - 2014/4
N2 - Objective: Milk may stimulate growth acting via insulin-like growth factor-I (IGF-I) secretion but the effect in adolescents is less examined. This study investigates the effect of milk proteins on linear growth, IGF-I, IGF binding protein-3 (IGFBP-3) and IGF-I/IGFBP-3 ratio in overweight adolescents. Design: The trial included 193 overweight adolescents aged 12-15. years. They were randomized to drink 1. L/day of: skimmed milk, whey, casein or water for 12. weeks; all milk-based drinks contained 35. g protein/L. A subgroup of 32 adolescents was examined 12. weeks before they were randomized into the groups and started the intervention (pre-test control group). Examinations included anthropometry, diet registration and blood samples which were analyzed for IGF-I and IGFBP-3 by chemiluminescence methods. The effects of milk-based drinks on linear growth, IGF-I, IGFBP-3 and IGF-I availability, calculated as the IGF-I/IGFBP-3 ratio, were compared with baseline, the pre-test control group and water. Results: IGF-I increased with skimmed milk (P = 0.015) and tended to increase with casein (P = 0.075) compared to the pre-test control group. IGFBP-3 but not IGF-I increased with skimmed milk (P = 0.006) and casein (P = 0.001) compared to water. There was no difference in height or height Z-score for any of the milk-based test drink groups compared to water or compared to the pre-test control group. However, height Z-score decreased within the whey group. Conclusions: Skimmed milk and casein may have a stimulating effect on the IGF-I system whereas there was no positive effect on height in overweight adolescents during this 12. week intervention.
AB - Objective: Milk may stimulate growth acting via insulin-like growth factor-I (IGF-I) secretion but the effect in adolescents is less examined. This study investigates the effect of milk proteins on linear growth, IGF-I, IGF binding protein-3 (IGFBP-3) and IGF-I/IGFBP-3 ratio in overweight adolescents. Design: The trial included 193 overweight adolescents aged 12-15. years. They were randomized to drink 1. L/day of: skimmed milk, whey, casein or water for 12. weeks; all milk-based drinks contained 35. g protein/L. A subgroup of 32 adolescents was examined 12. weeks before they were randomized into the groups and started the intervention (pre-test control group). Examinations included anthropometry, diet registration and blood samples which were analyzed for IGF-I and IGFBP-3 by chemiluminescence methods. The effects of milk-based drinks on linear growth, IGF-I, IGFBP-3 and IGF-I availability, calculated as the IGF-I/IGFBP-3 ratio, were compared with baseline, the pre-test control group and water. Results: IGF-I increased with skimmed milk (P = 0.015) and tended to increase with casein (P = 0.075) compared to the pre-test control group. IGFBP-3 but not IGF-I increased with skimmed milk (P = 0.006) and casein (P = 0.001) compared to water. There was no difference in height or height Z-score for any of the milk-based test drink groups compared to water or compared to the pre-test control group. However, height Z-score decreased within the whey group. Conclusions: Skimmed milk and casein may have a stimulating effect on the IGF-I system whereas there was no positive effect on height in overweight adolescents during this 12. week intervention.
U2 - 10.1016/j.ghir.2013.12.004
DO - 10.1016/j.ghir.2013.12.004
M3 - Journal article
C2 - 24461794
SN - 1096-6374
VL - 24
SP - 54
EP - 59
JO - Growth Hormone & I G F Research
JF - Growth Hormone & I G F Research
IS - 2-3
ER -