Effect of meal and propranolol on whole body and splanchnic oxygen consumption in patients with cirrhosis

Aleksander Krag; Lene Simonsen; Jens H Henriksen; Lone Ottesen; Flemming Bendtsen; Aleksander Krag; L Simonsen; Jens Henrik Henriksen; L Ottesen; Flemming Bendtsen

doi:10.1152/ajpgi.00315.2005

Effect of meal and propranolol on whole body and splanchnic oxygen consumption in patients with cirrhosis

Aleksander Krag, Lene Simonsen, Jens H Henriksen, Lone Ottesen, Flemming Bendtsen, Aleksander Krag, L Simonsen, Jens Henrik Henriksen, L Ottesen, Flemming Bendtsen

Department of Clinical Medicine

3 Citations (Scopus)

Abstract

Our aim was to measure whole body energy expenditure after a mixed liquid meal, with and without simultaneous propranolol infusion, in patients with cirrhosis. We also wanted to investigate the effect of propranolol on substrate fluxes and oxygen uptake in the tissues drained by the hepatic vein and azygos vein in the postprandial period in these patients. Whole-body oxygen uptake, hepatic blood flow, hepatic venous pressure gradient and net-hepatic fluxes of oxygen, lactate, glucose, glycerol, and free fatty acids (FFA) were measured in 12 patients with alcoholic cirrhosis before and for 2 h after ingestion of a mixed liquid meal (700 kcal). Half of the patients (n = 6) were randomized to a treatment group receiving intravenous infusion of propranolol in combination with the meal. The meal-induced energy expenditure was significantly lower in patients given propranolol [15.0 +/- 18.9 vs. 67.0 +/- 26.1 kJ/120 min (means +/- SD), P < 0.01]. Meal-induced whole body oxygen uptake was lower in patients receiving propranolol (19.2 +/- 38 vs. 135.7 +/- 61 mmol/120 min, P < 0.01), and the meal-induced increase in splanchnic oxygen uptake was nonexistent when propranolol was administered in combination (-13.2 +/- 34.8 vs. 110.4 +/- 34.8 mmol/120 min, P = 0.04). Postprandially, the propranolol group had a tendency toward a reduced splanchnic glucose output, and the FFA uptake was significantly reduced. Propranolol reduces meal-induced whole body oxygen uptake and energy expenditure as well as splanchnic oxygen uptake. The splanchnic reduction in oxygen consumption can explain almost the entire reduction in whole body oxygen consumption.

Original language	English
Journal	American Journal of Physiology: Gastrointestinal and Liver Physiology
Volume	291
Issue number	1
Pages (from-to)	G8-15
ISSN	0193-1857
DOIs	https://doi.org/10.1152/ajpgi.00315.2005
Publication status	Published - 23 Feb 2006

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10.1152/ajpgi.00315.2005

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Krag, A., Simonsen, L., Henriksen, J. H., Ottesen, L., Bendtsen, F., Krag, A., Simonsen, L., Henriksen, J. H., Ottesen, L., & Bendtsen, F. (2006). Effect of meal and propranolol on whole body and splanchnic oxygen consumption in patients with cirrhosis. American Journal of Physiology: Gastrointestinal and Liver Physiology, 291(1), G8-15. https://doi.org/10.1152/ajpgi.00315.2005

Effect of meal and propranolol on whole body and splanchnic oxygen consumption in patients with cirrhosis. / Krag, Aleksander; Simonsen, Lene; Henriksen, Jens H et al.

In: American Journal of Physiology: Gastrointestinal and Liver Physiology, Vol. 291, No. 1, 23.02.2006, p. G8-15.

Research output: Contribution to journal › Journal article › Research › peer-review

Krag, A, Simonsen, L, Henriksen, JH, Ottesen, L, Bendtsen, F, Krag, A, Simonsen, L, Henriksen, JH, Ottesen, L & Bendtsen, F 2006, 'Effect of meal and propranolol on whole body and splanchnic oxygen consumption in patients with cirrhosis', American Journal of Physiology: Gastrointestinal and Liver Physiology, vol. 291, no. 1, pp. G8-15. https://doi.org/10.1152/ajpgi.00315.2005

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title = "Effect of meal and propranolol on whole body and splanchnic oxygen consumption in patients with cirrhosis",

abstract = "Our aim was to measure whole body energy expenditure after a mixed liquid meal, with and without simultaneous propranolol infusion, in patients with cirrhosis. We also wanted to investigate the effect of propranolol on substrate fluxes and oxygen uptake in the tissues drained by the hepatic vein and azygos vein in the postprandial period in these patients. Whole-body oxygen uptake, hepatic blood flow, hepatic venous pressure gradient and net-hepatic fluxes of oxygen, lactate, glucose, glycerol, and free fatty acids (FFA) were measured in 12 patients with alcoholic cirrhosis before and for 2 h after ingestion of a mixed liquid meal (700 kcal). Half of the patients (n = 6) were randomized to a treatment group receiving intravenous infusion of propranolol in combination with the meal. The meal-induced energy expenditure was significantly lower in patients given propranolol [15.0 +/- 18.9 vs. 67.0 +/- 26.1 kJ/120 min (means +/- SD), P < 0.01]. Meal-induced whole body oxygen uptake was lower in patients receiving propranolol (19.2 +/- 38 vs. 135.7 +/- 61 mmol/120 min, P < 0.01), and the meal-induced increase in splanchnic oxygen uptake was nonexistent when propranolol was administered in combination (-13.2 +/- 34.8 vs. 110.4 +/- 34.8 mmol/120 min, P = 0.04). Postprandially, the propranolol group had a tendency toward a reduced splanchnic glucose output, and the FFA uptake was significantly reduced. Propranolol reduces meal-induced whole body oxygen uptake and energy expenditure as well as splanchnic oxygen uptake. The splanchnic reduction in oxygen consumption can explain almost the entire reduction in whole body oxygen consumption.",

author = "Aleksander Krag and Lene Simonsen and Henriksen, {Jens H} and Lone Ottesen and Flemming Bendtsen and Aleksander Krag and L Simonsen and Henriksen, {Jens Henrik} and L Ottesen and Flemming Bendtsen",

note = "Keywords: Dose-Response Relationship, Drug; Energy Metabolism; Female; Humans; Infusions, Intravenous; Liver Cirrhosis; Male; Metabolic Clearance Rate; Middle Aged; Organ Specificity; Oxygen; Oxygen Consumption; Postprandial Period; Propranolol; Splanchnic Circulation; Tissue Distribution",

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T1 - Effect of meal and propranolol on whole body and splanchnic oxygen consumption in patients with cirrhosis

AU - Krag, Aleksander

AU - Simonsen, Lene

AU - Henriksen, Jens H

AU - Ottesen, Lone

AU - Bendtsen, Flemming

AU - Krag, Aleksander

AU - Simonsen, L

AU - Henriksen, Jens Henrik

AU - Ottesen, L

AU - Bendtsen, Flemming

N1 - Keywords: Dose-Response Relationship, Drug; Energy Metabolism; Female; Humans; Infusions, Intravenous; Liver Cirrhosis; Male; Metabolic Clearance Rate; Middle Aged; Organ Specificity; Oxygen; Oxygen Consumption; Postprandial Period; Propranolol; Splanchnic Circulation; Tissue Distribution

PY - 2006/2/23

Y1 - 2006/2/23

N2 - Our aim was to measure whole body energy expenditure after a mixed liquid meal, with and without simultaneous propranolol infusion, in patients with cirrhosis. We also wanted to investigate the effect of propranolol on substrate fluxes and oxygen uptake in the tissues drained by the hepatic vein and azygos vein in the postprandial period in these patients. Whole-body oxygen uptake, hepatic blood flow, hepatic venous pressure gradient and net-hepatic fluxes of oxygen, lactate, glucose, glycerol, and free fatty acids (FFA) were measured in 12 patients with alcoholic cirrhosis before and for 2 h after ingestion of a mixed liquid meal (700 kcal). Half of the patients (n = 6) were randomized to a treatment group receiving intravenous infusion of propranolol in combination with the meal. The meal-induced energy expenditure was significantly lower in patients given propranolol [15.0 +/- 18.9 vs. 67.0 +/- 26.1 kJ/120 min (means +/- SD), P < 0.01]. Meal-induced whole body oxygen uptake was lower in patients receiving propranolol (19.2 +/- 38 vs. 135.7 +/- 61 mmol/120 min, P < 0.01), and the meal-induced increase in splanchnic oxygen uptake was nonexistent when propranolol was administered in combination (-13.2 +/- 34.8 vs. 110.4 +/- 34.8 mmol/120 min, P = 0.04). Postprandially, the propranolol group had a tendency toward a reduced splanchnic glucose output, and the FFA uptake was significantly reduced. Propranolol reduces meal-induced whole body oxygen uptake and energy expenditure as well as splanchnic oxygen uptake. The splanchnic reduction in oxygen consumption can explain almost the entire reduction in whole body oxygen consumption.

AB - Our aim was to measure whole body energy expenditure after a mixed liquid meal, with and without simultaneous propranolol infusion, in patients with cirrhosis. We also wanted to investigate the effect of propranolol on substrate fluxes and oxygen uptake in the tissues drained by the hepatic vein and azygos vein in the postprandial period in these patients. Whole-body oxygen uptake, hepatic blood flow, hepatic venous pressure gradient and net-hepatic fluxes of oxygen, lactate, glucose, glycerol, and free fatty acids (FFA) were measured in 12 patients with alcoholic cirrhosis before and for 2 h after ingestion of a mixed liquid meal (700 kcal). Half of the patients (n = 6) were randomized to a treatment group receiving intravenous infusion of propranolol in combination with the meal. The meal-induced energy expenditure was significantly lower in patients given propranolol [15.0 +/- 18.9 vs. 67.0 +/- 26.1 kJ/120 min (means +/- SD), P < 0.01]. Meal-induced whole body oxygen uptake was lower in patients receiving propranolol (19.2 +/- 38 vs. 135.7 +/- 61 mmol/120 min, P < 0.01), and the meal-induced increase in splanchnic oxygen uptake was nonexistent when propranolol was administered in combination (-13.2 +/- 34.8 vs. 110.4 +/- 34.8 mmol/120 min, P = 0.04). Postprandially, the propranolol group had a tendency toward a reduced splanchnic glucose output, and the FFA uptake was significantly reduced. Propranolol reduces meal-induced whole body oxygen uptake and energy expenditure as well as splanchnic oxygen uptake. The splanchnic reduction in oxygen consumption can explain almost the entire reduction in whole body oxygen consumption.

U2 - 10.1152/ajpgi.00315.2005

DO - 10.1152/ajpgi.00315.2005

M3 - Journal article

C2 - 16500921

SN - 0193-1857

VL - 291

SP - G8-15

JO - American Journal of Physiology: Gastrointestinal and Liver Physiology

JF - American Journal of Physiology: Gastrointestinal and Liver Physiology

IS - 1

ER -

Effect of meal and propranolol on whole body and splanchnic oxygen consumption in patients with cirrhosis

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