Effect of Rosa canina L. (Rose-hip) on cold during winter season in a middle-class population: A randomized, double-blinded, placebo-controlled trial

TY - JOUR

T1 - Effect of Rosa canina L. (Rose-hip) on cold during winter season in a middle-class population

T2 - A randomized, double-blinded, placebo-controlled trial

AU - Winther, Kaj

AU - Warholm, Lina

AU - Campbell-Tofte, Joan

AU - Marstrand, Kristian

N1 - CURIS 2018 NEXS 376

PY - 2018/9

Y1 - 2018/9

N2 - Aim: The common cold has social and economic implications worldwide. This study aimed to test if a liquid standardised preparation, Hyben Vital, based on shells from Rose-hip (Rosa canina L.), reduces the incidence and symptoms of the common cold in Danish middle-class volunteers. Methods: Volunteers (n = 120) were randomly allocated to daily treatments with either 2 g of liquid Rose-hip (RH) or placebo (P) for six months during winter. Primary effect variables: The frequency of colds and symptoms related to cold. Secondary effect variables: Evaluations from diaries of muscle stiffness and general well-being (numerical scales). Results: A number of 107 volunteers completed the trial and 31 out of 58 patients (53.4%) in the P group reported cold vs 24 out of 55 patients (43.6%) in the RH group; 18.4% reduction (p = 0.348). The numbers of volunteers reporting the different symptoms of cold in P-group vs RH-group were: Coughing: 23 vs 18, p < 0.422; Headache: 26 vs 17, p < 0.112; Muscle stiffness: 27 vs 15, p < 0.027 and Fatigue: 29 vs 20, p < 0.115. Muscle stiffness, evaluated over 6 month, fell from initial 2.40 ± 2.32 to 2.02 ± 2.15 in the RH group and from 2.37 ± 2.40 to 2.93 ± 2.50 in the P group, (p < 0.043, comparing groups). The delta improvement in general well-being was 0.21 ± 0.74 (p < 0.019) vs 0.12 ± 1.08 (p < 0.078) in the RH-and P group, respectively (p < 0.861, comparing groups). Conclusion: Our data suggest that administration of liquid Rose-hip reduces the incidence of colds by 18% and lowers the number of patients reporting the different symptoms of cold.

AB - Aim: The common cold has social and economic implications worldwide. This study aimed to test if a liquid standardised preparation, Hyben Vital, based on shells from Rose-hip (Rosa canina L.), reduces the incidence and symptoms of the common cold in Danish middle-class volunteers. Methods: Volunteers (n = 120) were randomly allocated to daily treatments with either 2 g of liquid Rose-hip (RH) or placebo (P) for six months during winter. Primary effect variables: The frequency of colds and symptoms related to cold. Secondary effect variables: Evaluations from diaries of muscle stiffness and general well-being (numerical scales). Results: A number of 107 volunteers completed the trial and 31 out of 58 patients (53.4%) in the P group reported cold vs 24 out of 55 patients (43.6%) in the RH group; 18.4% reduction (p = 0.348). The numbers of volunteers reporting the different symptoms of cold in P-group vs RH-group were: Coughing: 23 vs 18, p < 0.422; Headache: 26 vs 17, p < 0.112; Muscle stiffness: 27 vs 15, p < 0.027 and Fatigue: 29 vs 20, p < 0.115. Muscle stiffness, evaluated over 6 month, fell from initial 2.40 ± 2.32 to 2.02 ± 2.15 in the RH group and from 2.37 ± 2.40 to 2.93 ± 2.50 in the P group, (p < 0.043, comparing groups). The delta improvement in general well-being was 0.21 ± 0.74 (p < 0.019) vs 0.12 ± 1.08 (p < 0.078) in the RH-and P group, respectively (p < 0.861, comparing groups). Conclusion: Our data suggest that administration of liquid Rose-hip reduces the incidence of colds by 18% and lowers the number of patients reporting the different symptoms of cold.

KW - Arthritis

KW - Common cold

KW - Herbal treatment

KW - Inflammation

KW - Rosa canina

KW - Rose-hip

U2 - 10.1016/j.hermed.2018.04.003

DO - 10.1016/j.hermed.2018.04.003

M3 - Journal article

AN - SCOPUS:85047177834

SN - 2210-8033

VL - 13

SP - 34

EP - 41

JO - Journal of Herbal Medicine

JF - Journal of Herbal Medicine

ER -