Effect of Intracoronary and Intravenous Melatonin on Myocardial Salvage Index in Patients with ST-Elevation Myocardial Infarction: a Randomized Placebo Controlled Trial

Sarah Ekeloef; Natalie Halladin; Siv Fonnes; Svend Eggert Jensen; Tomas Zaremba; Jacob Rosenberg; Grete Jonsson; Jens Aarøe; Lærke Smidt Gasbjerg; Mette Marie Rosenkilde; Ismail Gögenur

doi:10.1007/s12265-017-9768-7

Effect of Intracoronary and Intravenous Melatonin on Myocardial Salvage Index in Patients with ST-Elevation Myocardial Infarction: a Randomized Placebo Controlled Trial

Sarah Ekeloef^*, Natalie Halladin, Siv Fonnes, Svend Eggert Jensen, Tomas Zaremba, Jacob Rosenberg, Grete Jonsson, Jens Aarøe, Lærke Smidt Gasbjerg, Mette Marie Rosenkilde, Ismail Gögenur

^*Corresponding author for this work

15 Citations (Scopus)

Abstract

Melatonin has attenuated myocardial ischemia reperfusion injury in experimental studies. We hypothesized that the administration of melatonin during acute myocardial reperfusion improves myocardial salvage index in patients with ST-elevation myocardial infarction. Patients (n = 48) were randomized in a 1:1 ratio to intracoronary and intravenous melatonin (total 50 mg) or placebo. The myocardial salvage index assessed by cardiac magnetic resonance imaging at day 4 (± 1 day) after primary percutaneous coronary intervention was similar in the melatonin group (n = 22) at 55.3% (95% CI 47.0–63.6) and the placebo group (n = 19) at 61.5% (95% CI 57.5–65.5), p = 0.21. The levels of high-sensitive troponin T, creatinine kinase myocardial band, and oxidative biomarkers (advanced oxidation protein products, malondialdehyde, myeloperoxidase) were similar in the groups. The frequency of clinical events at 90 days did not differ between the groups. In conclusion, melatonin did not improve the myocardial salvage index after primary percutaneous coronary intervention in patients with ST elevation myocardial infarction compared with placebo.

Original language	English
Journal	Journal of Cardiovascular Translational Research
Volume	10
Issue number	5-6
Pages (from-to)	470-479
Number of pages	10
ISSN	1937-5387
DOIs	https://doi.org/10.1007/s12265-017-9768-7
Publication status	Published - Dec 2017

Keywords

Acute myocardial infarction
Ischemic heart disease
Melatonin
Myocardial reperfusion injury
Primary percutaneous coronary intervention

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Ekeloef, S., Halladin, N., Fonnes, S., Jensen, S. E., Zaremba, T., Rosenberg, J., Jonsson, G., Aarøe, J., Gasbjerg, L. S., Rosenkilde, M. M., & Gögenur, I. (2017). Effect of Intracoronary and Intravenous Melatonin on Myocardial Salvage Index in Patients with ST-Elevation Myocardial Infarction: a Randomized Placebo Controlled Trial. Journal of Cardiovascular Translational Research, 10(5-6), 470-479. https://doi.org/10.1007/s12265-017-9768-7

Effect of Intracoronary and Intravenous Melatonin on Myocardial Salvage Index in Patients with ST-Elevation Myocardial Infarction: a Randomized Placebo Controlled Trial. / Ekeloef, Sarah; Halladin, Natalie; Fonnes, Siv et al.
In: Journal of Cardiovascular Translational Research, Vol. 10, No. 5-6, 12.2017, p. 470-479.

Research output: Contribution to journal › Journal article › Research › peer-review

Ekeloef, S, Halladin, N, Fonnes, S, Jensen, SE, Zaremba, T, Rosenberg, J, Jonsson, G, Aarøe, J, Gasbjerg, LS , Rosenkilde, MM & Gögenur, I 2017, 'Effect of Intracoronary and Intravenous Melatonin on Myocardial Salvage Index in Patients with ST-Elevation Myocardial Infarction: a Randomized Placebo Controlled Trial', Journal of Cardiovascular Translational Research, vol. 10, no. 5-6, pp. 470-479. https://doi.org/10.1007/s12265-017-9768-7

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title = "Effect of Intracoronary and Intravenous Melatonin on Myocardial Salvage Index in Patients with ST-Elevation Myocardial Infarction: a Randomized Placebo Controlled Trial",

abstract = "Melatonin has attenuated myocardial ischemia reperfusion injury in experimental studies. We hypothesized that the administration of melatonin during acute myocardial reperfusion improves myocardial salvage index in patients with ST-elevation myocardial infarction. Patients (n = 48) were randomized in a 1:1 ratio to intracoronary and intravenous melatonin (total 50 mg) or placebo. The myocardial salvage index assessed by cardiac magnetic resonance imaging at day 4 (± 1 day) after primary percutaneous coronary intervention was similar in the melatonin group (n = 22) at 55.3% (95% CI 47.0–63.6) and the placebo group (n = 19) at 61.5% (95% CI 57.5–65.5), p = 0.21. The levels of high-sensitive troponin T, creatinine kinase myocardial band, and oxidative biomarkers (advanced oxidation protein products, malondialdehyde, myeloperoxidase) were similar in the groups. The frequency of clinical events at 90 days did not differ between the groups. In conclusion, melatonin did not improve the myocardial salvage index after primary percutaneous coronary intervention in patients with ST elevation myocardial infarction compared with placebo.",

keywords = "Acute myocardial infarction, Ischemic heart disease, Melatonin, Myocardial reperfusion injury, Primary percutaneous coronary intervention",

author = "Sarah Ekeloef and Natalie Halladin and Siv Fonnes and Jensen, {Svend Eggert} and Tomas Zaremba and Jacob Rosenberg and Grete Jonsson and Jens Aar{\o}e and Gasbjerg, {L{\ae}rke Smidt} and Rosenkilde, {Mette Marie} and Ismail G{\"o}genur",

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T1 - Effect of Intracoronary and Intravenous Melatonin on Myocardial Salvage Index in Patients with ST-Elevation Myocardial Infarction

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AU - Ekeloef, Sarah

AU - Halladin, Natalie

AU - Fonnes, Siv

AU - Jensen, Svend Eggert

AU - Zaremba, Tomas

AU - Rosenberg, Jacob

AU - Jonsson, Grete

AU - Aarøe, Jens

AU - Gasbjerg, Lærke Smidt

AU - Rosenkilde, Mette Marie

AU - Gögenur, Ismail

PY - 2017/12

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N2 - Melatonin has attenuated myocardial ischemia reperfusion injury in experimental studies. We hypothesized that the administration of melatonin during acute myocardial reperfusion improves myocardial salvage index in patients with ST-elevation myocardial infarction. Patients (n = 48) were randomized in a 1:1 ratio to intracoronary and intravenous melatonin (total 50 mg) or placebo. The myocardial salvage index assessed by cardiac magnetic resonance imaging at day 4 (± 1 day) after primary percutaneous coronary intervention was similar in the melatonin group (n = 22) at 55.3% (95% CI 47.0–63.6) and the placebo group (n = 19) at 61.5% (95% CI 57.5–65.5), p = 0.21. The levels of high-sensitive troponin T, creatinine kinase myocardial band, and oxidative biomarkers (advanced oxidation protein products, malondialdehyde, myeloperoxidase) were similar in the groups. The frequency of clinical events at 90 days did not differ between the groups. In conclusion, melatonin did not improve the myocardial salvage index after primary percutaneous coronary intervention in patients with ST elevation myocardial infarction compared with placebo.

AB - Melatonin has attenuated myocardial ischemia reperfusion injury in experimental studies. We hypothesized that the administration of melatonin during acute myocardial reperfusion improves myocardial salvage index in patients with ST-elevation myocardial infarction. Patients (n = 48) were randomized in a 1:1 ratio to intracoronary and intravenous melatonin (total 50 mg) or placebo. The myocardial salvage index assessed by cardiac magnetic resonance imaging at day 4 (± 1 day) after primary percutaneous coronary intervention was similar in the melatonin group (n = 22) at 55.3% (95% CI 47.0–63.6) and the placebo group (n = 19) at 61.5% (95% CI 57.5–65.5), p = 0.21. The levels of high-sensitive troponin T, creatinine kinase myocardial band, and oxidative biomarkers (advanced oxidation protein products, malondialdehyde, myeloperoxidase) were similar in the groups. The frequency of clinical events at 90 days did not differ between the groups. In conclusion, melatonin did not improve the myocardial salvage index after primary percutaneous coronary intervention in patients with ST elevation myocardial infarction compared with placebo.

KW - Acute myocardial infarction

KW - Ischemic heart disease

KW - Melatonin

KW - Myocardial reperfusion injury

KW - Primary percutaneous coronary intervention

U2 - 10.1007/s12265-017-9768-7

DO - 10.1007/s12265-017-9768-7

M3 - Journal article

C2 - 29027116

AN - SCOPUS:85031415342

SN - 1937-5387

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JO - Journal of Cardiovascular Translational Research

JF - Journal of Cardiovascular Translational Research

IS - 5-6

ER -

Effect of Intracoronary and Intravenous Melatonin on Myocardial Salvage Index in Patients with ST-Elevation Myocardial Infarction: a Randomized Placebo Controlled Trial

Abstract

Keywords

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