Abstract
The changes in MR-determined synovial membrane volume, early synovial enhancement, and cartilage and bone erosions after osmic acid knee synovectomy were studied. Gadolinium-DTPA enhanced magnetic resonance imaging (MRI) of 18 knees with persistent arthritis was performed before and 1 month after treatment. The synovial membrane volume was significantly reduced (median -52%) in all 9 patients brought into clinical remission (p < 0.01), while no significant change was found in patients with clinical relapse. The early synovial enhancement was not significantly changed. MRI revealed progressive erosive changes in 2 patients. The time of relapse was correlated to a MR-erosion score, but not to early synovial enhancement or volumes of synovium or effusion (Spearman tests). MRI-determined synovial membrane volumes and early synovial enhancement may be objective quantitative markers of inflammation. MR-scores of cartilage and bone erosions are sensitive to progressive changes occurring within a month.
| Translated title of the contribution | Effect of intraarticular osmic acid on synovial membrane volume and inflammation, determined by magnetic resonance imaging. |
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| Original language | English |
| Journal | Scandinavian Journal of Rheumatology |
| Volume | 24 |
| Issue number | 1 |
| Pages (from-to) | 5-12 |
| Number of pages | 8 |
| ISSN | 0300-9742 |
| Publication status | Published - 1995 |