Effect of intermittent aerobic exercise on sleep quality and sleep disturbances in patients with rheumatoid arthritis: design of a randomized controlled trial

Katrine Løppenthin; Bente Appel Esbensen; Poul Jennum; Mikkel Østergaard; Jesper Frank Christensen; Tanja Thomsen; Julie Schjerbech Bech; Julie Midtgaard

doi:10.1186/1471-2474-15-49

Effect of intermittent aerobic exercise on sleep quality and sleep disturbances in patients with rheumatoid arthritis: design of a randomized controlled trial

Katrine Løppenthin, Bente Appel Esbensen, Poul Jennum, Mikkel Østergaard, Jesper Frank Christensen, Tanja Thomsen, Julie Schjerbech Bech, Julie Midtgaard

18 Citations (Scopus)

Abstract

BACKGROUND: Poor sleep is prevalent in patients with systemic inflammatory disorders, including rheumatoid arthritis, and, in addition to fatigue, pain, depression and inflammation, is associated with an increased risk of co-morbidity and all-cause mortality. Whereas non-pharmacological interventions in patients with rheumatoid arthritis have been shown to reduce pain and fatigue, no randomized controlled trials have examined the effect of non-pharmacological interventions on improvement of sleep in patients with rheumatoid arthritis. The aim of this trial was to evaluate the efficacy of an intermittent aerobic exercise intervention on sleep, assessed both objectively and subjectively in patients with rheumatoid arthritis.

METHODS/DESIGN: A randomized controlled trial including 44 patients with rheumatoid arthritis randomly assigned to an exercise training intervention or to a control group. The intervention consists of 18 session intermittent aerobic exercise training on a bicycle ergometer three times a week. Patients are evaluated according to objective changes in sleep as measured by polysomnography (primary outcome). Secondary outcomes include changes in subjective sleep quality and sleep disturbances, fatigue, pain, depressive symptoms, physical function, health-related quality of life and cardiorespiratory fitness.

DISCUSSION: This trial will provide evidence of the effect of intermittent aerobic exercise on the improvement of sleep in patients with rheumatoid arthritis, which is considered important in promotion of health and well-being. As such, the trial meets a currently unmet need for the provision of non-pharmacological treatment initiatives of poor sleep in patients with rheumatoid arthritis.

TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01966835.

Original language	English
Journal	BMC Musculoskeletal Disorders
Volume	15
Pages (from-to)	1-8
Number of pages	8
ISSN	1471-2474
DOIs	https://doi.org/10.1186/1471-2474-15-49
Publication status	Published - 21 Feb 2014

Keywords

Adolescent
Adult
Aged
Arthritis, Rheumatoid
Exercise
Fatigue
Female
Humans
Male
Middle Aged
Patient Selection
Polysomnography
Single-Blind Method
Sleep Disorders, Intrinsic
Young Adult

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10.1186/1471-2474-15-49

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Løppenthin, K., Esbensen, B. A., Jennum, P., Østergaard, M., Christensen, J. F., Thomsen, T., Bech, J. S., & Midtgaard, J. (2014). Effect of intermittent aerobic exercise on sleep quality and sleep disturbances in patients with rheumatoid arthritis: design of a randomized controlled trial. BMC Musculoskeletal Disorders, 15, 1-8. https://doi.org/10.1186/1471-2474-15-49

Effect of intermittent aerobic exercise on sleep quality and sleep disturbances in patients with rheumatoid arthritis : design of a randomized controlled trial. / Løppenthin, Katrine; Esbensen, Bente Appel ; Jennum, Poul et al.

In: BMC Musculoskeletal Disorders, Vol. 15, 21.02.2014, p. 1-8.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "BACKGROUND: Poor sleep is prevalent in patients with systemic inflammatory disorders, including rheumatoid arthritis, and, in addition to fatigue, pain, depression and inflammation, is associated with an increased risk of co-morbidity and all-cause mortality. Whereas non-pharmacological interventions in patients with rheumatoid arthritis have been shown to reduce pain and fatigue, no randomized controlled trials have examined the effect of non-pharmacological interventions on improvement of sleep in patients with rheumatoid arthritis. The aim of this trial was to evaluate the efficacy of an intermittent aerobic exercise intervention on sleep, assessed both objectively and subjectively in patients with rheumatoid arthritis.METHODS/DESIGN: A randomized controlled trial including 44 patients with rheumatoid arthritis randomly assigned to an exercise training intervention or to a control group. The intervention consists of 18 session intermittent aerobic exercise training on a bicycle ergometer three times a week. Patients are evaluated according to objective changes in sleep as measured by polysomnography (primary outcome). Secondary outcomes include changes in subjective sleep quality and sleep disturbances, fatigue, pain, depressive symptoms, physical function, health-related quality of life and cardiorespiratory fitness.DISCUSSION: This trial will provide evidence of the effect of intermittent aerobic exercise on the improvement of sleep in patients with rheumatoid arthritis, which is considered important in promotion of health and well-being. As such, the trial meets a currently unmet need for the provision of non-pharmacological treatment initiatives of poor sleep in patients with rheumatoid arthritis.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01966835.",

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AU - Esbensen, Bente Appel

AU - Jennum, Poul

AU - Østergaard, Mikkel

AU - Christensen, Jesper Frank

AU - Thomsen, Tanja

AU - Bech, Julie Schjerbech

AU - Midtgaard, Julie

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N2 - BACKGROUND: Poor sleep is prevalent in patients with systemic inflammatory disorders, including rheumatoid arthritis, and, in addition to fatigue, pain, depression and inflammation, is associated with an increased risk of co-morbidity and all-cause mortality. Whereas non-pharmacological interventions in patients with rheumatoid arthritis have been shown to reduce pain and fatigue, no randomized controlled trials have examined the effect of non-pharmacological interventions on improvement of sleep in patients with rheumatoid arthritis. The aim of this trial was to evaluate the efficacy of an intermittent aerobic exercise intervention on sleep, assessed both objectively and subjectively in patients with rheumatoid arthritis.METHODS/DESIGN: A randomized controlled trial including 44 patients with rheumatoid arthritis randomly assigned to an exercise training intervention or to a control group. The intervention consists of 18 session intermittent aerobic exercise training on a bicycle ergometer three times a week. Patients are evaluated according to objective changes in sleep as measured by polysomnography (primary outcome). Secondary outcomes include changes in subjective sleep quality and sleep disturbances, fatigue, pain, depressive symptoms, physical function, health-related quality of life and cardiorespiratory fitness.DISCUSSION: This trial will provide evidence of the effect of intermittent aerobic exercise on the improvement of sleep in patients with rheumatoid arthritis, which is considered important in promotion of health and well-being. As such, the trial meets a currently unmet need for the provision of non-pharmacological treatment initiatives of poor sleep in patients with rheumatoid arthritis.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01966835.

AB - BACKGROUND: Poor sleep is prevalent in patients with systemic inflammatory disorders, including rheumatoid arthritis, and, in addition to fatigue, pain, depression and inflammation, is associated with an increased risk of co-morbidity and all-cause mortality. Whereas non-pharmacological interventions in patients with rheumatoid arthritis have been shown to reduce pain and fatigue, no randomized controlled trials have examined the effect of non-pharmacological interventions on improvement of sleep in patients with rheumatoid arthritis. The aim of this trial was to evaluate the efficacy of an intermittent aerobic exercise intervention on sleep, assessed both objectively and subjectively in patients with rheumatoid arthritis.METHODS/DESIGN: A randomized controlled trial including 44 patients with rheumatoid arthritis randomly assigned to an exercise training intervention or to a control group. The intervention consists of 18 session intermittent aerobic exercise training on a bicycle ergometer three times a week. Patients are evaluated according to objective changes in sleep as measured by polysomnography (primary outcome). Secondary outcomes include changes in subjective sleep quality and sleep disturbances, fatigue, pain, depressive symptoms, physical function, health-related quality of life and cardiorespiratory fitness.DISCUSSION: This trial will provide evidence of the effect of intermittent aerobic exercise on the improvement of sleep in patients with rheumatoid arthritis, which is considered important in promotion of health and well-being. As such, the trial meets a currently unmet need for the provision of non-pharmacological treatment initiatives of poor sleep in patients with rheumatoid arthritis.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01966835.

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JO - B M C Musculoskeletal Disorders

JF - B M C Musculoskeletal Disorders

ER -

Effect of intermittent aerobic exercise on sleep quality and sleep disturbances in patients with rheumatoid arthritis: design of a randomized controlled trial

Abstract

Keywords

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