Effect of high intensity exercise on peak oxygen uptake and endothelial function in long-term heart transplant recipients

TY - JOUR

T1 - Effect of high intensity exercise on peak oxygen uptake and endothelial function in long-term heart transplant recipients

AU - Hermann, T S

AU - Dall, C H

AU - Christensen, S B

AU - Goetze, J P

AU - Prescott, E

AU - Gustafsson, F

AU - Dall, Christian Have

AU - Christensen, S B

AU - Gøtze, Jens Peter

N1 - ©2011 The Authors Journal compilation©2011 The American Society of Transplantation and the American Society of Transplant Surgeons.

PY - 2011/3/1

Y1 - 2011/3/1

N2 - Coronary allograft vasculopathy is a well-known long-term complication after cardiac transplantation. Endothelial dysfunction is involved andmay be prevented by aerobic exercise. The purpose of this study was to examine whether high intensity aerobic exercise improves peak oxygen uptake (VO 2 peak) and endothelial function in heart transplant (HT) recipients. Twenty-seven long-term HT recipients were randomized to either 8-weeks high intensity aerobic exercise or no training. Flow mediated dilation of the brachial artery (FMD) was measured by ultrasound and VO2 peak by the analysis of expired air. Blood pressure and biomarkers were measured before and after 8 weeks. VO2 peak increased significantly in the exercise group (VO2 peak 23.9 ± 1.79 to 28.3 ± 1.63 mL/kg/min compared to controls (VO2 peak 24.6 ± 1.38 to 23.4 ± 1.58, p < 0.001 exercise vs. control). FMD increased in the exercise group compared to controls (8.3 ± 1.1% to 11.4 ± 1.2% vs. 5.6 ± 1.0% to 5.3 ± 1.7%, p = 0.024). No increase in nitroglycerin-induced vasodilation was observed. Systolic blood pressure fell in the exercise group (142 ± 4.2 mmHg to127 ± 3.4 mmHg, p = 0.01) and was unchanged in controls (141 ± 4.2 mmHg to 142 ± 6.4 mmHg, NS). High intensity aerobic exercise reduces systolic blood pressure and improves endothelial function in HT recipients.

AB - Coronary allograft vasculopathy is a well-known long-term complication after cardiac transplantation. Endothelial dysfunction is involved andmay be prevented by aerobic exercise. The purpose of this study was to examine whether high intensity aerobic exercise improves peak oxygen uptake (VO 2 peak) and endothelial function in heart transplant (HT) recipients. Twenty-seven long-term HT recipients were randomized to either 8-weeks high intensity aerobic exercise or no training. Flow mediated dilation of the brachial artery (FMD) was measured by ultrasound and VO2 peak by the analysis of expired air. Blood pressure and biomarkers were measured before and after 8 weeks. VO2 peak increased significantly in the exercise group (VO2 peak 23.9 ± 1.79 to 28.3 ± 1.63 mL/kg/min compared to controls (VO2 peak 24.6 ± 1.38 to 23.4 ± 1.58, p < 0.001 exercise vs. control). FMD increased in the exercise group compared to controls (8.3 ± 1.1% to 11.4 ± 1.2% vs. 5.6 ± 1.0% to 5.3 ± 1.7%, p = 0.024). No increase in nitroglycerin-induced vasodilation was observed. Systolic blood pressure fell in the exercise group (142 ± 4.2 mmHg to127 ± 3.4 mmHg, p = 0.01) and was unchanged in controls (141 ± 4.2 mmHg to 142 ± 6.4 mmHg, NS). High intensity aerobic exercise reduces systolic blood pressure and improves endothelial function in HT recipients.

U2 - 10.1111/j.1600-6143.2010.03403.x

DO - 10.1111/j.1600-6143.2010.03403.x

M3 - Journal article

C2 - 21219582

SN - 1600-6135

VL - 11

SP - 536

EP - 541

JO - American Journal of Transplantation

JF - American Journal of Transplantation

IS - 3

ER -