Effect of heme and heme oxygenase-1 on vascular endothelial growth factor synthesis and angiogenic potency of human keratinocytes

Agnieszka Jazwa; Agnieszka Loboda; Slawomir Golda; Jaroslaw Cisowski; Magdalena Szelag; Anna Zagorska; Patrycja Sroczynska; Justyna Drukala; Alicja Jozkowicz; Jozef Dulak

doi:10.1016/j.freeradbiomed.2005.11.016

Effect of heme and heme oxygenase-1 on vascular endothelial growth factor synthesis and angiogenic potency of human keratinocytes

Agnieszka Jazwa, Agnieszka Loboda, Slawomir Golda, Jaroslaw Cisowski, Magdalena Szelag, Anna Zagorska, Patrycja Sroczynska, Justyna Drukala, Alicja Jozkowicz, Jozef Dulak

84 Citations (Scopus)

Abstract

Skin injury leads to the release of heme, a potent prooxidant which is degraded by heme oxygenase-1 (HO-1) to carbon monoxide, iron, and biliverdin, subsequently reduced to bilirubin. Recently the involvement of HO-1 in angiogenesis has been shown; however, the role of heme and HO-1 in wound healing angiogenesis has not been yet investigated.

Original language	English
Journal	Free Radical Biology & Medicine
Volume	40
Issue number	7
Pages (from-to)	1250-63
Number of pages	14
ISSN	0891-5849
DOIs	https://doi.org/10.1016/j.freeradbiomed.2005.11.016
Publication status	Published - 1 Apr 2006
Externally published	Yes

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Jazwa, A, Loboda, A, Golda, S, Cisowski, J, Szelag, M, Zagorska, A, Sroczynska, P, Drukala, J, Jozkowicz, A & Dulak, J 2006, 'Effect of heme and heme oxygenase-1 on vascular endothelial growth factor synthesis and angiogenic potency of human keratinocytes', Free Radical Biology & Medicine, vol. 40, no. 7, pp. 1250-63. https://doi.org/10.1016/j.freeradbiomed.2005.11.016

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abstract = "Skin injury leads to the release of heme, a potent prooxidant which is degraded by heme oxygenase-1 (HO-1) to carbon monoxide, iron, and biliverdin, subsequently reduced to bilirubin. Recently the involvement of HO-1 in angiogenesis has been shown; however, the role of heme and HO-1 in wound healing angiogenesis has not been yet investigated.",

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AU - Jazwa, Agnieszka

AU - Loboda, Agnieszka

AU - Golda, Slawomir

AU - Cisowski, Jaroslaw

AU - Szelag, Magdalena

AU - Zagorska, Anna

AU - Sroczynska, Patrycja

AU - Drukala, Justyna

AU - Jozkowicz, Alicja

AU - Dulak, Jozef

PY - 2006/4/1

Y1 - 2006/4/1

N2 - Skin injury leads to the release of heme, a potent prooxidant which is degraded by heme oxygenase-1 (HO-1) to carbon monoxide, iron, and biliverdin, subsequently reduced to bilirubin. Recently the involvement of HO-1 in angiogenesis has been shown; however, the role of heme and HO-1 in wound healing angiogenesis has not been yet investigated.

AB - Skin injury leads to the release of heme, a potent prooxidant which is degraded by heme oxygenase-1 (HO-1) to carbon monoxide, iron, and biliverdin, subsequently reduced to bilirubin. Recently the involvement of HO-1 in angiogenesis has been shown; however, the role of heme and HO-1 in wound healing angiogenesis has not been yet investigated.

U2 - 10.1016/j.freeradbiomed.2005.11.016

DO - 10.1016/j.freeradbiomed.2005.11.016

M3 - Journal article

C2 - 16545694

SN - 0891-5849

VL - 40

SP - 1250

EP - 1263

JO - Free Radical Biology & Medicine

JF - Free Radical Biology & Medicine

IS - 7

ER -

Effect of heme and heme oxygenase-1 on vascular endothelial growth factor synthesis and angiogenic potency of human keratinocytes

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