Effect of folic and folinic acid on cytopenia occurring during co-trimoxazole treatment of Pneumocystis carinii pneumonia

TY - JOUR

T1 - Effect of folic and folinic acid on cytopenia occurring during co-trimoxazole treatment of Pneumocystis carinii pneumonia

AU - Bygbjerg, Ib Christian

AU - Lund, J T

AU - Hørding, M

PY - 1988/1/1

Y1 - 1988/1/1

N2 - 12 AIDS/ARC patients with or suspected of Pneumocystis carinii pneumonia were treated with co-trimoxazole and received supplementary folic or folinic acid to avoid peripheral blood cytopenia. Most patients developed decreased numbers of neutrophils and hemoglobin while receiving co-trimoxazole. Supplementary folate/folinate could not abolish the drug-induced cytopenia. Routine prescription of folinic acid is not recommended. Folic acid is cheap and may be beneficial and should be prescribed.

AB - 12 AIDS/ARC patients with or suspected of Pneumocystis carinii pneumonia were treated with co-trimoxazole and received supplementary folic or folinic acid to avoid peripheral blood cytopenia. Most patients developed decreased numbers of neutrophils and hemoglobin while receiving co-trimoxazole. Supplementary folate/folinate could not abolish the drug-induced cytopenia. Routine prescription of folinic acid is not recommended. Folic acid is cheap and may be beneficial and should be prescribed.

KW - AIDS-Related Complex

KW - Acquired Immunodeficiency Syndrome

KW - Anemia

KW - Drug Combinations

KW - Folic Acid

KW - Hematologic Diseases

KW - Humans

KW - Leucovorin

KW - Leukopenia

KW - Pneumonia, Pneumocystis

KW - Prospective Studies

KW - Sulfamethoxazole

KW - Thrombocytopenia

KW - Time Factors

KW - Trimethoprim

KW - Trimethoprim-Sulfamethoxazole Combination

M3 - Journal article

C2 - 3265540

SN - 2374-4235

VL - 20

SP - 685

EP - 686

JO - Infectious Diseases

JF - Infectious Diseases

IS - 6

ER -