Effect of exogenous estrogens and progestogens on the course of migraine during reproductive age: a consensus statement by the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESCRH)

Simona Sacco; Gabriele S Merki-Feld; Karen Lehrmann Ægidius; Johannes Bitzer; Marianne Canonico; Andreas R Gantenbein; Tobias Kurth; Christian Lampl; Øjvind Lidegaard; E Anne MacGregor; Antoinette MaassenVanDenBrink; Dimos-Dimitrios Mitsikostas; Rossella Elena Nappi; George Ntaios; Koen Paemeleire; Per Morten Sandset; Gisela Marie Terwindt; Kjersti Grøtta Vetvik; Paolo Martelletti; European Headache Federation (EHF), the European Society of Contraception and Reproductive Health (ESCRH)

doi:10.1186/s10194-018-0896-5

Effect of exogenous estrogens and progestogens on the course of migraine during reproductive age: a consensus statement by the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESCRH)

Simona Sacco, Gabriele S Merki-Feld, Karen Lehrmann Ægidius, Johannes Bitzer, Marianne Canonico, Andreas R Gantenbein, Tobias Kurth, Christian Lampl, Øjvind Lidegaard, E Anne MacGregor, Antoinette MaassenVanDenBrink, Dimos-Dimitrios Mitsikostas, Rossella Elena Nappi, George Ntaios, Koen Paemeleire, Per Morten Sandset, Gisela Marie Terwindt, Kjersti Grøtta Vetvik, Paolo Martelletti, European Headache Federation (EHF), the European Society of Contraception and Reproductive Health (ESCRH)

Department of Clinical Medicine

19 Citations (Scopus)

38 Downloads (Pure)

Abstract

We systematically reviewed data about the effect of exogenous estrogens and progestogens on the course of migraine during reproductive age. Thereafter a consensus procedure among international experts was undertaken to develop statements to support clinical decision making, in terms of possible effects on migraine course of exogenous estrogens and progestogens and on possible treatment of headache associated with the use or with the withdrawal of hormones. Overall, quality of current evidence is low. Recommendations are provided for all the compounds with available evidence including the conventional 21/7 combined hormonal contraception, the desogestrel only oral pill, combined oral contraceptives with shortened pill-free interval, combined oral contraceptives with estradiol supplementation during the pill-free interval, extended regimen of combined hormonal contraceptive with pill or patch, combined hormonal contraceptive vaginal ring, transdermal estradiol supplementation with gel, transdermal estradiol supplementation with patch, subcutaneous estrogen implant with cyclical oral progestogen. As the quality of available data is poor, further research is needed on this topic to improve the knowledge about the use of estrogens and progestogens in women with migraine. There is a need for better management of headaches related to the use of hormones or their withdrawal.

Original language	English
Article number	76
Journal	The Journal of Headache and Pain
Volume	19
Issue number	1
Pages (from-to)	1-21
ISSN	1129-2369
DOIs	https://doi.org/10.1186/s10194-018-0896-5
Publication status	Published - 31 Aug 2018

Keywords

Consensus
Contraception/methods
Contraceptives, Oral, Combined/administration & dosage
Desogestrel/administration & dosage
Estrogens/administration & dosage
Europe/epidemiology
Female
Headache/drug therapy
Humans
Migraine Disorders/drug therapy
Progestins/administration & dosage
Reproductive Health/standards
Societies, Medical/standards

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Effect of exogenous estrogens and progestogens on the course of migraine during reproductive age: a consensus statement by the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESCRH)Final published version, 1.24 MBLicence: CC BY

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Sacco, S., Merki-Feld, G. S., Ægidius, K. L., Bitzer, J., Canonico, M., Gantenbein, A. R., Kurth, T., Lampl, C., Lidegaard, Ø., Anne MacGregor, E., MaassenVanDenBrink, A., Mitsikostas, D-D., Nappi, R. E., Ntaios, G., Paemeleire, K., Sandset, P. M., Terwindt, G. M., Vetvik, K. G., Martelletti, P., & European Headache Federation (EHF), the European Society of Contraception and Reproductive Health (ESCRH) (2018). Effect of exogenous estrogens and progestogens on the course of migraine during reproductive age: a consensus statement by the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESCRH). The Journal of Headache and Pain, 19(1), 1-21. [76]. https://doi.org/10.1186/s10194-018-0896-5

Effect of exogenous estrogens and progestogens on the course of migraine during reproductive age : a consensus statement by the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESCRH). / Sacco, Simona; Merki-Feld, Gabriele S; Ægidius, Karen Lehrmann et al.

In: The Journal of Headache and Pain, Vol. 19, No. 1, 76, 31.08.2018, p. 1-21.

Research output: Contribution to journal › Review › peer-review

Sacco, S, Merki-Feld, GS, Ægidius, KL, Bitzer, J, Canonico, M, Gantenbein, AR, Kurth, T, Lampl, C, Lidegaard, Ø, Anne MacGregor, E, MaassenVanDenBrink, A, Mitsikostas, D-D, Nappi, RE, Ntaios, G, Paemeleire, K, Sandset, PM, Terwindt, GM, Vetvik, KG, Martelletti, P & European Headache Federation (EHF), the European Society of Contraception and Reproductive Health (ESCRH) 2018, 'Effect of exogenous estrogens and progestogens on the course of migraine during reproductive age: a consensus statement by the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESCRH)', The Journal of Headache and Pain, vol. 19, no. 1, 76, pp. 1-21. https://doi.org/10.1186/s10194-018-0896-5

Sacco S, Merki-Feld GS, Ægidius KL, Bitzer J, Canonico M, Gantenbein AR et al. Effect of exogenous estrogens and progestogens on the course of migraine during reproductive age: a consensus statement by the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESCRH). The Journal of Headache and Pain. 2018 Aug 31;19(1):1-21. 76. doi: 10.1186/s10194-018-0896-5

Sacco, Simona ; Merki-Feld, Gabriele S ; Ægidius, Karen Lehrmann et al. / Effect of exogenous estrogens and progestogens on the course of migraine during reproductive age : a consensus statement by the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESCRH). In: The Journal of Headache and Pain. 2018 ; Vol. 19, No. 1. pp. 1-21.

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abstract = "We systematically reviewed data about the effect of exogenous estrogens and progestogens on the course of migraine during reproductive age. Thereafter a consensus procedure among international experts was undertaken to develop statements to support clinical decision making, in terms of possible effects on migraine course of exogenous estrogens and progestogens and on possible treatment of headache associated with the use or with the withdrawal of hormones. Overall, quality of current evidence is low. Recommendations are provided for all the compounds with available evidence including the conventional 21/7 combined hormonal contraception, the desogestrel only oral pill, combined oral contraceptives with shortened pill-free interval, combined oral contraceptives with estradiol supplementation during the pill-free interval, extended regimen of combined hormonal contraceptive with pill or patch, combined hormonal contraceptive vaginal ring, transdermal estradiol supplementation with gel, transdermal estradiol supplementation with patch, subcutaneous estrogen implant with cyclical oral progestogen. As the quality of available data is poor, further research is needed on this topic to improve the knowledge about the use of estrogens and progestogens in women with migraine. There is a need for better management of headaches related to the use of hormones or their withdrawal.",

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