Effect of aerobic exercise on physical performance in patients with Alzheimer’s disease

Nanna Aue Sobol; Kristine Hoffmann; Kristian Steen Frederiksen; Asmus Vogel; Karsten Vestergaard; Hans Brændgaard; Hanne Gottrup; Annette Lolk; Lene Wermuth; Søren Jakobsen; Lars Laugesen; Robert Gergelyffy; Peter Høgh; Eva Bjerregaard; Volkert Dirk Siersma; Birgitte Bo Andersen; Peter Johannsen; Gunhild Waldemar; Steen Gregers Hasselbalch; Nina Beyer

doi:10.1016/j.jalz.2016.05.004

Effect of aerobic exercise on physical performance in patients with Alzheimer’s disease

Nanna Aue Sobol, Kristine Hoffmann, Kristian Steen Frederiksen, Asmus Vogel, Karsten Vestergaard, Hans Brændgaard, Hanne Gottrup, Annette Lolk, Lene Wermuth, Søren Jakobsen, Lars Laugesen, Robert Gergelyffy, Peter Høgh, Eva Bjerregaard, Volkert Dirk Siersma, Birgitte Bo Andersen, Peter Johannsen, Gunhild Waldemar, Steen Gregers Hasselbalch, Nina Beyer

36 Citations (Scopus)

Abstract

Introduction Knowledge about the feasibility and effects of exercise programs to persons with Alzheimer's disease is lacking. This study investigated the effect of aerobic exercise on physical performance in community-dwelling persons with mild Alzheimer's disease. Methods The single blinded multi-center RCT (ADEX) included 200 patients, median age 71 yrs (50-89). The intervention group received supervised moderate-to-high intensity aerobic exercise 1 hour × 3/week for 16 weeks. Assessments included cardiorespiratory fitness, single-task physical performance, dual-task performance and exercise self-efficacy. Results Significant between-group differences in change from baseline (mean [95%CI]) favored the intervention group for cardiorespiratory fitness (4.0 [2.3-5.8] ml/kg/min, P <0.0001) and exercise self-efficacy (1.7 [0.5-2.8] points, P =0.004). Furthermore, an exercise attendance of ≥66.6% resulted in significant positive effects on single-task physical performance and dual-task performance. Discussion Aerobic exercise has the potential to improve cardiorespiratory fitness, single-task physical performance, dual-task performance and exercise self-efficacy in community-dwelling patients with mild Alzheimer's disease.

Original language	English
Journal	Alzheimer's & Dementia
Volume	12
Issue number	12
Pages (from-to)	1207–1215
Number of pages	9
ISSN	1552-5260
DOIs	https://doi.org/10.1016/j.jalz.2016.05.004
Publication status	Published - 1 Dec 2016

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Sobol, N. A., Hoffmann, K., Frederiksen, K. S., Vogel, A., Vestergaard, K., Brændgaard, H., Gottrup, H., Lolk, A., Wermuth, L., Jakobsen, S., Laugesen, L., Gergelyffy, R., Høgh, P., Bjerregaard, E., Siersma, V. D., Andersen, B. B., Johannsen, P., Waldemar, G., Hasselbalch, S. G., & Beyer, N. (2016). Effect of aerobic exercise on physical performance in patients with Alzheimer’s disease. Alzheimer's & Dementia, 12(12), 1207–1215. https://doi.org/10.1016/j.jalz.2016.05.004

Sobol, NA, Hoffmann, K, Frederiksen, KS, Vogel, A, Vestergaard, K, Brændgaard, H, Gottrup, H, Lolk, A, Wermuth, L, Jakobsen, S, Laugesen, L, Gergelyffy, R, Høgh, P, Bjerregaard, E, Siersma, VD, Andersen, BB, Johannsen, P, Waldemar, G, Hasselbalch, SG & Beyer, N 2016, 'Effect of aerobic exercise on physical performance in patients with Alzheimer’s disease', Alzheimer's & Dementia, vol. 12, no. 12, pp. 1207–1215. https://doi.org/10.1016/j.jalz.2016.05.004

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abstract = "Introduction Knowledge about the feasibility and effects of exercise programs to persons with Alzheimer's disease is lacking. This study investigated the effect of aerobic exercise on physical performance in community-dwelling persons with mild Alzheimer's disease. Methods The single blinded multi-center RCT (ADEX) included 200 patients, median age 71 yrs (50-89). The intervention group received supervised moderate-to-high intensity aerobic exercise 1 hour × 3/week for 16 weeks. Assessments included cardiorespiratory fitness, single-task physical performance, dual-task performance and exercise self-efficacy. Results Significant between-group differences in change from baseline (mean [95%CI]) favored the intervention group for cardiorespiratory fitness (4.0 [2.3-5.8] ml/kg/min, P <0.0001) and exercise self-efficacy (1.7 [0.5-2.8] points, P =0.004). Furthermore, an exercise attendance of ≥66.6% resulted in significant positive effects on single-task physical performance and dual-task performance. Discussion Aerobic exercise has the potential to improve cardiorespiratory fitness, single-task physical performance, dual-task performance and exercise self-efficacy in community-dwelling patients with mild Alzheimer's disease.",

author = "Sobol, {Nanna Aue} and Kristine Hoffmann and Frederiksen, {Kristian Steen} and Asmus Vogel and Karsten Vestergaard and Hans Br{\ae}ndgaard and Hanne Gottrup and Annette Lolk and Lene Wermuth and S{\o}ren Jakobsen and Lars Laugesen and Robert Gergelyffy and Peter H{\o}gh and Eva Bjerregaard and Siersma, {Volkert Dirk} and Andersen, {Birgitte Bo} and Peter Johannsen and Gunhild Waldemar and Hasselbalch, {Steen Gregers} and Nina Beyer",

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T1 - Effect of aerobic exercise on physical performance in patients with Alzheimer’s disease

AU - Sobol, Nanna Aue

AU - Hoffmann, Kristine

AU - Frederiksen, Kristian Steen

AU - Vogel, Asmus

AU - Vestergaard, Karsten

AU - Brændgaard, Hans

AU - Gottrup, Hanne

AU - Lolk, Annette

AU - Wermuth, Lene

AU - Jakobsen, Søren

AU - Laugesen, Lars

AU - Gergelyffy, Robert

AU - Høgh, Peter

AU - Bjerregaard, Eva

AU - Siersma, Volkert Dirk

AU - Andersen, Birgitte Bo

AU - Johannsen, Peter

AU - Waldemar, Gunhild

AU - Hasselbalch, Steen Gregers

AU - Beyer, Nina

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Introduction Knowledge about the feasibility and effects of exercise programs to persons with Alzheimer's disease is lacking. This study investigated the effect of aerobic exercise on physical performance in community-dwelling persons with mild Alzheimer's disease. Methods The single blinded multi-center RCT (ADEX) included 200 patients, median age 71 yrs (50-89). The intervention group received supervised moderate-to-high intensity aerobic exercise 1 hour × 3/week for 16 weeks. Assessments included cardiorespiratory fitness, single-task physical performance, dual-task performance and exercise self-efficacy. Results Significant between-group differences in change from baseline (mean [95%CI]) favored the intervention group for cardiorespiratory fitness (4.0 [2.3-5.8] ml/kg/min, P <0.0001) and exercise self-efficacy (1.7 [0.5-2.8] points, P =0.004). Furthermore, an exercise attendance of ≥66.6% resulted in significant positive effects on single-task physical performance and dual-task performance. Discussion Aerobic exercise has the potential to improve cardiorespiratory fitness, single-task physical performance, dual-task performance and exercise self-efficacy in community-dwelling patients with mild Alzheimer's disease.

AB - Introduction Knowledge about the feasibility and effects of exercise programs to persons with Alzheimer's disease is lacking. This study investigated the effect of aerobic exercise on physical performance in community-dwelling persons with mild Alzheimer's disease. Methods The single blinded multi-center RCT (ADEX) included 200 patients, median age 71 yrs (50-89). The intervention group received supervised moderate-to-high intensity aerobic exercise 1 hour × 3/week for 16 weeks. Assessments included cardiorespiratory fitness, single-task physical performance, dual-task performance and exercise self-efficacy. Results Significant between-group differences in change from baseline (mean [95%CI]) favored the intervention group for cardiorespiratory fitness (4.0 [2.3-5.8] ml/kg/min, P <0.0001) and exercise self-efficacy (1.7 [0.5-2.8] points, P =0.004). Furthermore, an exercise attendance of ≥66.6% resulted in significant positive effects on single-task physical performance and dual-task performance. Discussion Aerobic exercise has the potential to improve cardiorespiratory fitness, single-task physical performance, dual-task performance and exercise self-efficacy in community-dwelling patients with mild Alzheimer's disease.

U2 - 10.1016/j.jalz.2016.05.004

DO - 10.1016/j.jalz.2016.05.004

M3 - Journal article

C2 - 27344641

SN - 1552-5260

VL - 12

SP - 1207

EP - 1215

JO - Alzheimer's & Dementia

JF - Alzheimer's & Dementia

IS - 12

ER -

Effect of aerobic exercise on physical performance in patients with Alzheimer’s disease

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