Effect of a chlorhexidine/thymol and a fluoride varnish on caries development in erupting permanent molars: a comparative study

TY - JOUR

T1 - Effect of a chlorhexidine/thymol and a fluoride varnish on caries development in erupting permanent molars

T2 - a comparative study

AU - Flamee, S

AU - Gizani, S

AU - Caroni, C

AU - Papagiannoulis, L

AU - Twetman, S

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Aim: To compare the caries preventive effect of a chlorhexidine/thymol-containing antibacterial varnish with a fluoride varnish when topically applied during the eruption of permanent molars. Methods: The study group consisted of 189 patients, 5–14 years of age, with one 1st or 2nd permanent molar in the process of eruption. After stratification for type of molar and stage of eruption, the patients were randomised to either quarterly topical applications with an antibacterial varnish (Cervitec® Plus; CV group) or biannual applications with a fluoride varnish plus biannual treatments with placebo varnish (Fluor Protector; FV group). The duration of the study was 2 years. The primary endpoint was caries incidence (initial and cavitated) in the erupting molars and the secondary outcome was salivary mutans streptococci (MS) counts. Results: The groups were balanced with respect to socio-economy, oral hygiene, dietary habits and caries experience at baseline. The dropout rate was 11.6 %. The caries incidence was low (<10 %) in both groups and there was no significant difference between the CV and FV groups with respect to occlusal caries development in the erupting molars (relative risk 1.08, 95 % CI 0.94–1.25). Significantly lower levels of salivary MS were disclosed in the CV group at the end of the study (p < 0.05). Conclusions: No difference in occlusal caries development in young permanent molars was displayed after topical applications of either a chlorhexidine/thymol varnish or a fluoride varnish during tooth eruption.

AB - Aim: To compare the caries preventive effect of a chlorhexidine/thymol-containing antibacterial varnish with a fluoride varnish when topically applied during the eruption of permanent molars. Methods: The study group consisted of 189 patients, 5–14 years of age, with one 1st or 2nd permanent molar in the process of eruption. After stratification for type of molar and stage of eruption, the patients were randomised to either quarterly topical applications with an antibacterial varnish (Cervitec® Plus; CV group) or biannual applications with a fluoride varnish plus biannual treatments with placebo varnish (Fluor Protector; FV group). The duration of the study was 2 years. The primary endpoint was caries incidence (initial and cavitated) in the erupting molars and the secondary outcome was salivary mutans streptococci (MS) counts. Results: The groups were balanced with respect to socio-economy, oral hygiene, dietary habits and caries experience at baseline. The dropout rate was 11.6 %. The caries incidence was low (<10 %) in both groups and there was no significant difference between the CV and FV groups with respect to occlusal caries development in the erupting molars (relative risk 1.08, 95 % CI 0.94–1.25). Significantly lower levels of salivary MS were disclosed in the CV group at the end of the study (p < 0.05). Conclusions: No difference in occlusal caries development in young permanent molars was displayed after topical applications of either a chlorhexidine/thymol varnish or a fluoride varnish during tooth eruption.

KW - Adolescent

KW - Anti-Infective Agents, Local

KW - Bacterial Load

KW - Cariostatic Agents

KW - Child

KW - Child, Preschool

KW - Chlorhexidine

KW - DMF Index

KW - Dental Caries

KW - Dental Plaque

KW - Drug Combinations

KW - Fluorides, Topical

KW - Food Habits

KW - Humans

KW - Molar

KW - Oral Hygiene

KW - Polyurethanes

KW - Saliva

KW - Silanes

KW - Single-Blind Method

KW - Social Class

KW - Streptococcus mutans

KW - Thymol

KW - Tooth Eruption

U2 - 10.1007/s40368-015-0192-x

DO - 10.1007/s40368-015-0192-x

M3 - Journal article

C2 - 26059497

SN - 1818-6300

VL - 16

SP - 449

EP - 454

JO - European archives of paediatric dentistry

JF - European archives of paediatric dentistry

IS - 6

ER -