Economic benefits of methylmercury exposure control in Europe: Monetary value of neurotoxicity prevention

Martine Bellanger; Céline Pichery; Dominique Aerts; Marika Berglund; Argelia Castaño; Mája Cejchanová; Pierre Crettaz; Fred Davidson; Marta Esteban; Marc E Fischer; Anca Elena Gurzau; Katarina Halzlova; Andromachi Katsonouri; Lisbeth E Knudsen; Marike Kolossa-Gehring; Gudrun Koppen; Danuta Ligocka; Ana Miklavčič; M Fátima Reis; Peter Rudnai; Janja Snoj Tratnik; Pál Weihe; Esben Budtz-Jørgensen; Philippe Grandjean; DEMO/COPHES

doi:10.1186/1476-069X-12-3

Economic benefits of methylmercury exposure control in Europe: Monetary value of neurotoxicity prevention

Martine Bellanger, Céline Pichery, Dominique Aerts, Marika Berglund, Argelia Castaño, Mája Cejchanová, Pierre Crettaz, Fred Davidson, Marta Esteban, Marc E Fischer, Anca Elena Gurzau, Katarina Halzlova, Andromachi Katsonouri, Lisbeth E Knudsen, Marike Kolossa-Gehring, Gudrun Koppen, Danuta Ligocka, Ana Miklavčič, M Fátima Reis, Peter RudnaiJanja Snoj Tratnik, Pál Weihe, Esben Budtz-Jørgensen, Philippe Grandjean, DEMO/COPHES

92 Citations (Scopus)

Abstract

BACKGROUND: Due to global mercury pollution and the adverse health effects of prenatal exposure to methylmercury (MeHg), an assessment of the economic benefits of prevented developmental neurotoxicity is necessary for any cost-benefit analysis.

METHODS: Distributions of hair-Hg concentrations among women of reproductive age were obtained from the DEMOCOPHES project (1,875 subjects in 17 countries) and literature data (6,820 subjects from 8 countries). The exposures were assumed to comply with log-normal distributions. Neurotoxicity effects were estimated from a linear dose-response function with a slope of 0.465 Intelligence Quotient (IQ) point reduction per μg/g increase in the maternal hair-Hg concentration during pregnancy, assuming no deficits below a hair-Hg limit of 0.58 μg/g thought to be safe. A logarithmic IQ response was used in sensitivity analyses. The estimated IQ benefit cost was based on lifetime income, adjusted for purchasing power parity.

RESULTS: The hair-mercury concentrations were the highest in Southern Europe and lowest in Eastern Europe. The results suggest that, within the EU, more than 1.8 million children are born every year with MeHg exposures above the limit of 0.58 μg/g, and about 200,000 births exceed a higher limit of 2.5 μg/g proposed by the World Health Organization (WHO). The total annual benefits of exposure prevention within the EU were estimated at more than 600,000 IQ points per year, corresponding to a total economic benefit between €8,000 million and €9,000 million per year. About four-fold higher values were obtained when using the logarithmic response function, while adjustment for productivity resulted in slightly lower total benefits. These calculations do not include the less tangible advantages of protecting brain development against neurotoxicity or any other adverse effects.

CONCLUSIONS: These estimates document that efforts to combat mercury pollution and to reduce MeHg exposures will have very substantial economic benefits in Europe, mainly in southern countries. Some data may not be entirely representative, some countries were not covered, and anticipated changes in mercury pollution all suggest a need for extended biomonitoring of human MeHg exposure.

Original language	English
Article number	3
Journal	Environmental Health
Volume	12
ISSN	1476-069X
DOIs	https://doi.org/10.1186/1476-069X-12-3
Publication status	Published - 2013

Keywords

Child
Environmental Exposure
Environmental Pollutants
Europe
Female
Hair
Humans
Intelligence
Maternal Exposure
Methylmercury Compounds
Neurotoxicity Syndromes
Pregnancy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/1476-069X-12-3

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Bellanger, M., Pichery, C., Aerts, D., Berglund, M., Castaño, A., Cejchanová, M., Crettaz, P., Davidson, F., Esteban, M., Fischer, M. E., Gurzau, A. E., Halzlova, K., Katsonouri, A., Knudsen, L. E., Kolossa-Gehring, M., Koppen, G., Ligocka, D., Miklavčič, A., Reis, M. F., ... DEMO/COPHES (2013). Economic benefits of methylmercury exposure control in Europe: Monetary value of neurotoxicity prevention. Environmental Health, 12, Article 3. https://doi.org/10.1186/1476-069X-12-3

Bellanger, M, Pichery, C, Aerts, D, Berglund, M, Castaño, A, Cejchanová, M, Crettaz, P, Davidson, F, Esteban, M, Fischer, ME, Gurzau, AE, Halzlova, K, Katsonouri, A, Knudsen, LE, Kolossa-Gehring, M, Koppen, G, Ligocka, D, Miklavčič, A, Reis, MF, Rudnai, P, Tratnik, JS, Weihe, P, Budtz-Jørgensen, E, Grandjean, P & DEMO/COPHES 2013, 'Economic benefits of methylmercury exposure control in Europe: Monetary value of neurotoxicity prevention', Environmental Health, vol. 12, 3. https://doi.org/10.1186/1476-069X-12-3

@article{33b442544d7843c286e30bb5dff5cba2,

title = "Economic benefits of methylmercury exposure control in Europe: Monetary value of neurotoxicity prevention",

abstract = "BACKGROUND: Due to global mercury pollution and the adverse health effects of prenatal exposure to methylmercury (MeHg), an assessment of the economic benefits of prevented developmental neurotoxicity is necessary for any cost-benefit analysis.METHODS: Distributions of hair-Hg concentrations among women of reproductive age were obtained from the DEMOCOPHES project (1,875 subjects in 17 countries) and literature data (6,820 subjects from 8 countries). The exposures were assumed to comply with log-normal distributions. Neurotoxicity effects were estimated from a linear dose-response function with a slope of 0.465 Intelligence Quotient (IQ) point reduction per μg/g increase in the maternal hair-Hg concentration during pregnancy, assuming no deficits below a hair-Hg limit of 0.58 μg/g thought to be safe. A logarithmic IQ response was used in sensitivity analyses. The estimated IQ benefit cost was based on lifetime income, adjusted for purchasing power parity.RESULTS: The hair-mercury concentrations were the highest in Southern Europe and lowest in Eastern Europe. The results suggest that, within the EU, more than 1.8 million children are born every year with MeHg exposures above the limit of 0.58 μg/g, and about 200,000 births exceed a higher limit of 2.5 μg/g proposed by the World Health Organization (WHO). The total annual benefits of exposure prevention within the EU were estimated at more than 600,000 IQ points per year, corresponding to a total economic benefit between €8,000 million and €9,000 million per year. About four-fold higher values were obtained when using the logarithmic response function, while adjustment for productivity resulted in slightly lower total benefits. These calculations do not include the less tangible advantages of protecting brain development against neurotoxicity or any other adverse effects.CONCLUSIONS: These estimates document that efforts to combat mercury pollution and to reduce MeHg exposures will have very substantial economic benefits in Europe, mainly in southern countries. Some data may not be entirely representative, some countries were not covered, and anticipated changes in mercury pollution all suggest a need for extended biomonitoring of human MeHg exposure.",

keywords = "Child, Environmental Exposure, Environmental Pollutants, Europe, Female, Hair, Humans, Intelligence, Maternal Exposure, Methylmercury Compounds, Neurotoxicity Syndromes, Pregnancy",

author = "Martine Bellanger and C{\'e}line Pichery and Dominique Aerts and Marika Berglund and Argelia Casta{\~n}o and M{\'a}ja Cejchanov{\'a} and Pierre Crettaz and Fred Davidson and Marta Esteban and Fischer, {Marc E} and Gurzau, {Anca Elena} and Katarina Halzlova and Andromachi Katsonouri and Knudsen, {Lisbeth E} and Marike Kolossa-Gehring and Gudrun Koppen and Danuta Ligocka and Ana Miklav{\v c}i{\v c} and Reis, {M F{\'a}tima} and Peter Rudnai and Tratnik, {Janja Snoj} and P{\'a}l Weihe and Esben Budtz-J{\o}rgensen and Philippe Grandjean and DEMO/COPHES",

year = "2013",

doi = "10.1186/1476-069X-12-3",

language = "English",

volume = "12",

journal = "Environmental Health",

issn = "1476-069X",

publisher = "BioMed Central Ltd.",

}

TY - JOUR

T1 - Economic benefits of methylmercury exposure control in Europe: Monetary value of neurotoxicity prevention

AU - Bellanger, Martine

AU - Pichery, Céline

AU - Aerts, Dominique

AU - Berglund, Marika

AU - Castaño, Argelia

AU - Cejchanová, Mája

AU - Crettaz, Pierre

AU - Davidson, Fred

AU - Esteban, Marta

AU - Fischer, Marc E

AU - Gurzau, Anca Elena

AU - Halzlova, Katarina

AU - Katsonouri, Andromachi

AU - Knudsen, Lisbeth E

AU - Kolossa-Gehring, Marike

AU - Koppen, Gudrun

AU - Ligocka, Danuta

AU - Miklavčič, Ana

AU - Reis, M Fátima

AU - Rudnai, Peter

AU - Tratnik, Janja Snoj

AU - Weihe, Pál

AU - Budtz-Jørgensen, Esben

AU - Grandjean, Philippe

AU - DEMO/COPHES

PY - 2013

Y1 - 2013

N2 - BACKGROUND: Due to global mercury pollution and the adverse health effects of prenatal exposure to methylmercury (MeHg), an assessment of the economic benefits of prevented developmental neurotoxicity is necessary for any cost-benefit analysis.METHODS: Distributions of hair-Hg concentrations among women of reproductive age were obtained from the DEMOCOPHES project (1,875 subjects in 17 countries) and literature data (6,820 subjects from 8 countries). The exposures were assumed to comply with log-normal distributions. Neurotoxicity effects were estimated from a linear dose-response function with a slope of 0.465 Intelligence Quotient (IQ) point reduction per μg/g increase in the maternal hair-Hg concentration during pregnancy, assuming no deficits below a hair-Hg limit of 0.58 μg/g thought to be safe. A logarithmic IQ response was used in sensitivity analyses. The estimated IQ benefit cost was based on lifetime income, adjusted for purchasing power parity.RESULTS: The hair-mercury concentrations were the highest in Southern Europe and lowest in Eastern Europe. The results suggest that, within the EU, more than 1.8 million children are born every year with MeHg exposures above the limit of 0.58 μg/g, and about 200,000 births exceed a higher limit of 2.5 μg/g proposed by the World Health Organization (WHO). The total annual benefits of exposure prevention within the EU were estimated at more than 600,000 IQ points per year, corresponding to a total economic benefit between €8,000 million and €9,000 million per year. About four-fold higher values were obtained when using the logarithmic response function, while adjustment for productivity resulted in slightly lower total benefits. These calculations do not include the less tangible advantages of protecting brain development against neurotoxicity or any other adverse effects.CONCLUSIONS: These estimates document that efforts to combat mercury pollution and to reduce MeHg exposures will have very substantial economic benefits in Europe, mainly in southern countries. Some data may not be entirely representative, some countries were not covered, and anticipated changes in mercury pollution all suggest a need for extended biomonitoring of human MeHg exposure.

AB - BACKGROUND: Due to global mercury pollution and the adverse health effects of prenatal exposure to methylmercury (MeHg), an assessment of the economic benefits of prevented developmental neurotoxicity is necessary for any cost-benefit analysis.METHODS: Distributions of hair-Hg concentrations among women of reproductive age were obtained from the DEMOCOPHES project (1,875 subjects in 17 countries) and literature data (6,820 subjects from 8 countries). The exposures were assumed to comply with log-normal distributions. Neurotoxicity effects were estimated from a linear dose-response function with a slope of 0.465 Intelligence Quotient (IQ) point reduction per μg/g increase in the maternal hair-Hg concentration during pregnancy, assuming no deficits below a hair-Hg limit of 0.58 μg/g thought to be safe. A logarithmic IQ response was used in sensitivity analyses. The estimated IQ benefit cost was based on lifetime income, adjusted for purchasing power parity.RESULTS: The hair-mercury concentrations were the highest in Southern Europe and lowest in Eastern Europe. The results suggest that, within the EU, more than 1.8 million children are born every year with MeHg exposures above the limit of 0.58 μg/g, and about 200,000 births exceed a higher limit of 2.5 μg/g proposed by the World Health Organization (WHO). The total annual benefits of exposure prevention within the EU were estimated at more than 600,000 IQ points per year, corresponding to a total economic benefit between €8,000 million and €9,000 million per year. About four-fold higher values were obtained when using the logarithmic response function, while adjustment for productivity resulted in slightly lower total benefits. These calculations do not include the less tangible advantages of protecting brain development against neurotoxicity or any other adverse effects.CONCLUSIONS: These estimates document that efforts to combat mercury pollution and to reduce MeHg exposures will have very substantial economic benefits in Europe, mainly in southern countries. Some data may not be entirely representative, some countries were not covered, and anticipated changes in mercury pollution all suggest a need for extended biomonitoring of human MeHg exposure.

KW - Child

KW - Environmental Exposure

KW - Environmental Pollutants

KW - Europe

KW - Female

KW - Hair

KW - Humans

KW - Intelligence

KW - Maternal Exposure

KW - Methylmercury Compounds

KW - Neurotoxicity Syndromes

KW - Pregnancy

U2 - 10.1186/1476-069X-12-3

DO - 10.1186/1476-069X-12-3

M3 - Journal article

C2 - 23289875

SN - 1476-069X

VL - 12

JO - Environmental Health

JF - Environmental Health

M1 - 3

ER -

Economic benefits of methylmercury exposure control in Europe: Monetary value of neurotoxicity prevention

Abstract

Keywords

UN SDGs

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