TY - JOUR
T1 - Echocardiographic assessment of left ventricular function in mitral regurgitation
T2 - is the dog a useful model of man?
AU - Zois, Nora Elisabeth
AU - Pedersen, Henrik D.
AU - Häggström, Jens
AU - Olsen, Lisbeth Høier
PY - 2014
Y1 - 2014
N2 - Myxomatous mitral valve disease (MMVD) is the most common cause of primary mitral regurgitation in humans and the most common cardiac disease in dogs. Many similarities have been described and, therefore, the dog is considered to be a suitable natural model for MMVD in humans. Accurate identification of incipient myocardial deterioration is crucial to optimally time interventional surgery. Nonetheless, this issue is still an object of controversy. In this respect, studies of left ventricular (LV) function in dogs with MMVD could potentially be useful. The present review compares the results obtained in echocardiographic studies of LV function in humans and dogs with MMVD. Although different study designs pose a limitation and results within the two species are not entirely concordant, it appears that LV function is better preserved in small-sized and medium-sized dogs than in humans. This may limit the usefulness of dogs as a model for LV function in MMVD. Cardiovasc Endocrinol 3:9-14
AB - Myxomatous mitral valve disease (MMVD) is the most common cause of primary mitral regurgitation in humans and the most common cardiac disease in dogs. Many similarities have been described and, therefore, the dog is considered to be a suitable natural model for MMVD in humans. Accurate identification of incipient myocardial deterioration is crucial to optimally time interventional surgery. Nonetheless, this issue is still an object of controversy. In this respect, studies of left ventricular (LV) function in dogs with MMVD could potentially be useful. The present review compares the results obtained in echocardiographic studies of LV function in humans and dogs with MMVD. Although different study designs pose a limitation and results within the two species are not entirely concordant, it appears that LV function is better preserved in small-sized and medium-sized dogs than in humans. This may limit the usefulness of dogs as a model for LV function in MMVD. Cardiovasc Endocrinol 3:9-14
U2 - 10.1097/XCE.0000000000000028
DO - 10.1097/XCE.0000000000000028
M3 - Review
SN - 2162-6898
VL - 3
SP - 9
EP - 14
JO - Cardiovascular Endocrinology
JF - Cardiovascular Endocrinology
IS - 1
ER -