Early puberty in internationally adopted girls: hormonal and clinical markers of puberty in 276 girls examined biannually over two years

Grete Teilmann; Jørgen H Petersen; Magdalena Gormsen; Karen Damgaard; Niels E Skakkebaek; Tina Kold Jensen; Grete Teilmann; Jørgen Holm Petersen; Magdalena Gormsen; Karen Damgaard; Niels E Skakkebaek; Tina Kold Jensen

doi:10.1159/000236085

Early puberty in internationally adopted girls: hormonal and clinical markers of puberty in 276 girls examined biannually over two years

Grete Teilmann, Jørgen H Petersen, Magdalena Gormsen, Karen Damgaard, Niels E Skakkebaek, Tina Kold Jensen, Grete Teilmann, Jørgen Holm Petersen, Magdalena Gormsen, Karen Damgaard, Niels E Skakkebaek, Tina Kold Jensen

31 Citations (Scopus)

Abstract

BACKGROUND AND AIMS: Retrospective studies have indicated that internationally adopted girls are at high risk of developing precocious puberty. Hypothetically, this could be due to selection bias. The aim of this study was to determine age at reaching pubertal milestones in healthy internationally adopted girls in a prospective, clinical study. METHODS: A longitudinal cohort study including 276 randomly recruited internationally adopted girls. At baseline, age ranged from 4 to 13 years. Participants were followed with biannual examinations over a period of 2 years. Examinations included height, weight, Tanner staging, blood sampling and bone age assessment. Age distribution at entering pubertal stages B2-B5 (breast development), PH1-PH5 (pubic hair development) and menarche was estimated by probit analysis. Data were compared to a reference population of Danish-born girls, studied cross-sectionally. RESULTS: Mean age at B2+ was 9.5 years (95% prediction interval 7.1-12.0 years) and mean age at menarche was 12.1 (10.2-14.0) years in adopted girls, which was significantly lower compared to the reference group (p < 0.0003). 16% of adopted girls entered stage B2 before 8 years of age. The puberty-related rise in LH, FSH and estradiol was detected at earlier ages in adopted girls compared to the reference group. CONCLUSION: Internationally adopted girls have a significantly higher risk of precocious pubertal maturation compared to Danish-born girls.

Original language	English
Journal	Hormone Research
Volume	72
Issue number	4
Pages (from-to)	236-46
Number of pages	11
ISSN	0301-0163
DOIs	https://doi.org/10.1159/000236085 https://doi.org/10.1159/000236085
Publication status	Published - 1 Jan 2009

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Teilmann, G., Petersen, J. H., Gormsen, M., Damgaard, K., Skakkebaek, N. E., Jensen, T. K., Teilmann, G., Petersen, J. H., Gormsen, M., Damgaard, K., Skakkebaek, N. E., & Jensen, T. K. (2009). Early puberty in internationally adopted girls: hormonal and clinical markers of puberty in 276 girls examined biannually over two years. Hormone Research, 72(4), 236-46. https://doi.org/10.1159/000236085, https://doi.org/10.1159/000236085

Teilmann, G , Petersen, JH, Gormsen, M, Damgaard, K, Skakkebaek, NE, Jensen, TK, Teilmann, G, Petersen, JH, Gormsen, M, Damgaard, K, Skakkebaek, NE & Jensen, TK 2009, 'Early puberty in internationally adopted girls: hormonal and clinical markers of puberty in 276 girls examined biannually over two years', Hormone Research, vol. 72, no. 4, pp. 236-46. https://doi.org/10.1159/000236085, https://doi.org/10.1159/000236085

@article{9722d53068a111df928f000ea68e967b,

title = "Early puberty in internationally adopted girls: hormonal and clinical markers of puberty in 276 girls examined biannually over two years",

abstract = "BACKGROUND AND AIMS: Retrospective studies have indicated that internationally adopted girls are at high risk of developing precocious puberty. Hypothetically, this could be due to selection bias. The aim of this study was to determine age at reaching pubertal milestones in healthy internationally adopted girls in a prospective, clinical study. METHODS: A longitudinal cohort study including 276 randomly recruited internationally adopted girls. At baseline, age ranged from 4 to 13 years. Participants were followed with biannual examinations over a period of 2 years. Examinations included height, weight, Tanner staging, blood sampling and bone age assessment. Age distribution at entering pubertal stages B2-B5 (breast development), PH1-PH5 (pubic hair development) and menarche was estimated by probit analysis. Data were compared to a reference population of Danish-born girls, studied cross-sectionally. RESULTS: Mean age at B2+ was 9.5 years (95% prediction interval 7.1-12.0 years) and mean age at menarche was 12.1 (10.2-14.0) years in adopted girls, which was significantly lower compared to the reference group (p < 0.0003). 16% of adopted girls entered stage B2 before 8 years of age. The puberty-related rise in LH, FSH and estradiol was detected at earlier ages in adopted girls compared to the reference group. CONCLUSION: Internationally adopted girls have a significantly higher risk of precocious pubertal maturation compared to Danish-born girls.",

author = "Grete Teilmann and Petersen, {J{\o}rgen H} and Magdalena Gormsen and Karen Damgaard and Skakkebaek, {Niels E} and Jensen, {Tina Kold} and Grete Teilmann and Petersen, {J{\o}rgen Holm} and Magdalena Gormsen and Karen Damgaard and Skakkebaek, {Niels E} and Jensen, {Tina Kold}",

note = "Keywords: Adolescent; Adoption; Age Determination by Skeleton; Aging; Birth Weight; Body Mass Index; Breast; Child; Child, Preschool; Confidence Intervals; Denmark; Emigrants and Immigrants; Estradiol; Female; Gonadotropins, Pituitary; Humans; Inhibins; Longitudinal Studies; Menarche; Puberty, Precocious; Sex Hormone-Binding Globulin; Socioeconomic Factors",

year = "2009",

month = jan,

day = "1",

doi = "10.1159/000236085",

language = "English",

volume = "72",

pages = "236--46",

journal = "Hormone Research",

issn = "0301-0163",

publisher = "S./Karger AG",

number = "4",

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TY - JOUR

T1 - Early puberty in internationally adopted girls: hormonal and clinical markers of puberty in 276 girls examined biannually over two years

AU - Teilmann, Grete

AU - Petersen, Jørgen H

AU - Gormsen, Magdalena

AU - Damgaard, Karen

AU - Skakkebaek, Niels E

AU - Jensen, Tina Kold

AU - Teilmann, Grete

AU - Petersen, Jørgen Holm

AU - Gormsen, Magdalena

AU - Damgaard, Karen

AU - Skakkebaek, Niels E

AU - Jensen, Tina Kold

N1 - Keywords: Adolescent; Adoption; Age Determination by Skeleton; Aging; Birth Weight; Body Mass Index; Breast; Child; Child, Preschool; Confidence Intervals; Denmark; Emigrants and Immigrants; Estradiol; Female; Gonadotropins, Pituitary; Humans; Inhibins; Longitudinal Studies; Menarche; Puberty, Precocious; Sex Hormone-Binding Globulin; Socioeconomic Factors

PY - 2009/1/1

Y1 - 2009/1/1

N2 - BACKGROUND AND AIMS: Retrospective studies have indicated that internationally adopted girls are at high risk of developing precocious puberty. Hypothetically, this could be due to selection bias. The aim of this study was to determine age at reaching pubertal milestones in healthy internationally adopted girls in a prospective, clinical study. METHODS: A longitudinal cohort study including 276 randomly recruited internationally adopted girls. At baseline, age ranged from 4 to 13 years. Participants were followed with biannual examinations over a period of 2 years. Examinations included height, weight, Tanner staging, blood sampling and bone age assessment. Age distribution at entering pubertal stages B2-B5 (breast development), PH1-PH5 (pubic hair development) and menarche was estimated by probit analysis. Data were compared to a reference population of Danish-born girls, studied cross-sectionally. RESULTS: Mean age at B2+ was 9.5 years (95% prediction interval 7.1-12.0 years) and mean age at menarche was 12.1 (10.2-14.0) years in adopted girls, which was significantly lower compared to the reference group (p < 0.0003). 16% of adopted girls entered stage B2 before 8 years of age. The puberty-related rise in LH, FSH and estradiol was detected at earlier ages in adopted girls compared to the reference group. CONCLUSION: Internationally adopted girls have a significantly higher risk of precocious pubertal maturation compared to Danish-born girls.

AB - BACKGROUND AND AIMS: Retrospective studies have indicated that internationally adopted girls are at high risk of developing precocious puberty. Hypothetically, this could be due to selection bias. The aim of this study was to determine age at reaching pubertal milestones in healthy internationally adopted girls in a prospective, clinical study. METHODS: A longitudinal cohort study including 276 randomly recruited internationally adopted girls. At baseline, age ranged from 4 to 13 years. Participants were followed with biannual examinations over a period of 2 years. Examinations included height, weight, Tanner staging, blood sampling and bone age assessment. Age distribution at entering pubertal stages B2-B5 (breast development), PH1-PH5 (pubic hair development) and menarche was estimated by probit analysis. Data were compared to a reference population of Danish-born girls, studied cross-sectionally. RESULTS: Mean age at B2+ was 9.5 years (95% prediction interval 7.1-12.0 years) and mean age at menarche was 12.1 (10.2-14.0) years in adopted girls, which was significantly lower compared to the reference group (p < 0.0003). 16% of adopted girls entered stage B2 before 8 years of age. The puberty-related rise in LH, FSH and estradiol was detected at earlier ages in adopted girls compared to the reference group. CONCLUSION: Internationally adopted girls have a significantly higher risk of precocious pubertal maturation compared to Danish-born girls.

U2 - 10.1159/000236085

DO - 10.1159/000236085

M3 - Journal article

C2 - 19786795

SN - 0301-0163

VL - 72

SP - 236

EP - 246

JO - Hormone Research

JF - Hormone Research

IS - 4

ER -

Early puberty in internationally adopted girls: hormonal and clinical markers of puberty in 276 girls examined biannually over two years

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