Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation

Emma L. Clayton; Renzo Mancuso; Troels Tolstrup Nielsen; Sarah Mizielinska; Holly Holmes; Nicholas Powell; Frances Norona; Jytte Overgaard Larsen; Carmelo Milioto; Katherine M. Wilson; Mark F. Lythgoe; Sebastian Ourselin; Jorgen E. Nielsen; Peter Johannsen; Ida Holm; John Collinge; Peter L. Oliver; Diego Gomez-Nicola; Adrian M. Isaacs

doi:10.1093/hmg/ddx003

Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation

Emma L. Clayton, Renzo Mancuso, Troels Tolstrup Nielsen, Sarah Mizielinska, Holly Holmes, Nicholas Powell, Frances Norona, Jytte Overgaard Larsen, Carmelo Milioto, Katherine M. Wilson, Mark F. Lythgoe, Sebastian Ourselin, Jorgen E. Nielsen, Peter Johannsen, Ida Holm, John Collinge, Peter L. Oliver, Diego Gomez-Nicola, Adrian M. Isaacs

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Original language	English
Journal	Human Molecular Genetics
Volume	26
Issue number	5
Pages (from-to)	873-887
Number of pages	15
ISSN	0964-6906
DOIs	https://doi.org/10.1093/hmg/ddx003
Publication status	Published - 1 Mar 2017

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10.1093/hmg/ddx003Licence: CC BY

Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutationFinal published version, 1.37 MBLicence: CC BY

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Clayton, E. L., Mancuso, R., Nielsen, T. T., Mizielinska, S., Holmes, H., Powell, N., Norona, F., Larsen, J. O., Milioto, C., Wilson, K. M., Lythgoe, M. F., Ourselin, S., Nielsen, J. E., Johannsen, P., Holm, I., Collinge, J., Oliver, P. L., Gomez-Nicola, D., & Isaacs, A. M. (2017). Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation. Human Molecular Genetics, 26(5), 873-887. https://doi.org/10.1093/hmg/ddx003

Clayton, EL, Mancuso, R, Nielsen, TT, Mizielinska, S, Holmes, H, Powell, N, Norona, F, Larsen, JO, Milioto, C, Wilson, KM, Lythgoe, MF, Ourselin, S, Nielsen, JE, Johannsen, P, Holm, I, Collinge, J, Oliver, PL, Gomez-Nicola, D & Isaacs, AM 2017, 'Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation', Human Molecular Genetics, vol. 26, no. 5, pp. 873-887. https://doi.org/10.1093/hmg/ddx003

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title = "Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation",

author = "Clayton, {Emma L.} and Renzo Mancuso and Nielsen, {Troels Tolstrup} and Sarah Mizielinska and Holly Holmes and Nicholas Powell and Frances Norona and Larsen, {Jytte Overgaard} and Carmelo Milioto and Wilson, {Katherine M.} and Lythgoe, {Mark F.} and Sebastian Ourselin and Nielsen, {Jorgen E.} and Peter Johannsen and Ida Holm and John Collinge and Oliver, {Peter L.} and Diego Gomez-Nicola and Isaacs, {Adrian M.}",

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AU - Clayton, Emma L.

AU - Mancuso, Renzo

AU - Nielsen, Troels Tolstrup

AU - Mizielinska, Sarah

AU - Holmes, Holly

AU - Powell, Nicholas

AU - Norona, Frances

AU - Larsen, Jytte Overgaard

AU - Milioto, Carmelo

AU - Wilson, Katherine M.

AU - Lythgoe, Mark F.

AU - Ourselin, Sebastian

AU - Nielsen, Jorgen E.

AU - Johannsen, Peter

AU - Holm, Ida

AU - Collinge, John

AU - Oliver, Peter L.

AU - Gomez-Nicola, Diego

AU - Isaacs, Adrian M.

PY - 2017/3/1

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DO - 10.1093/hmg/ddx003

M3 - Journal article

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SN - 0964-6906

VL - 26

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EP - 887

JO - Human Molecular Genetics

JF - Human Molecular Genetics

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Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation

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