Early laparotomy after lung transplantation: Increased incidence for patients with α1-anti-trypsin deficiency

Pia Bredahl; Mikhail Zemtsovski; Michael Perch; Dorte Levin Pedersen; Allan Rasmussen; Daniel Steinbrüchel; Jørn Carlsen; Martin Iversen

doi:10.1016/j.healun.2014.02.025

Early laparotomy after lung transplantation: Increased incidence for patients with α1-anti-trypsin deficiency

Pia Bredahl, Mikhail Zemtsovski, Michael Perch, Dorte Levin Pedersen, Allan Rasmussen, Daniel Steinbrüchel, Jørn Carlsen, Martin Iversen

Department of Clinical Medicine

9 Citations (Scopus)

Abstract

Background Gastrointestinal complications after lung transplantation have been reported with incidence rates ranging from 3% to 51%, but the reasons are poorly understood. We aimed to investigate the correlations between pulmonary diseases leading to lung transplantation and early gastrointestinal complications requiring laparotomy after transplantation with outcomes for patients at increased risk. Methods In this study we performed a retrospective analysis of data of patients who underwent lung transplantation at our institution from 2004 to 2012. The study period was limited to the first 90 days after transplantation. Results Lung transplantation was performed in 258 patients, including 51 patients with α₁-anti-trypsin deficiency (A1AD). Seventy-eight patients (30%) had an X-ray of the abdomen, and 23 patients (9%) required laparotomy during the first 90 days after transplantation. Patients with A1AD comprised 20% of the total recipients, 23% (18 of 78) of the patients who had an abdominal X-ray performed (p = 0.40), and 48% (11 of 23) of the patients who required laparotomy (p < 0.001). More than 1 of every 5 patients (11 of 51) with A1AD required laparotomy at a median 8 days after transplantation, and the estimated odds ratio for laparotomy for A1AD patients was 5.74 (CI 2.15 to 15.35). In the group of patients with A1AD who required laparotomy, the estimated hazard ratio for death was 1.62 (CI 0.57 to 4.62), the stay in the intensive care unit was prolonged, but no significant difference was observed for time on mechanical ventilation. Among pulmonary diseases and demographics of the patients, no other risk factors were identified for laparotomy. Conclusions A1AD was the only significant risk factor identified for gastrointestinal complications that required laparotomy within 3 months after lung transplantation. There was a trend toward a higher risk of death after laparotomy in patients with A1AD, and the length of stay in the intensive care unit was significantly prolonged, whereas the time on mechanical ventilation was unaffected.

Original language	English
Journal	Journal of Heart and Lung Transplantation
Volume	33
Issue number	7
Pages (from-to)	727-733
Number of pages	7
ISSN	1053-2498
DOIs	https://doi.org/10.1016/j.healun.2014.02.025
Publication status	Published - Jul 2014

Keywords

Adolescent
Adult
Child
Female
Gastrointestinal Diseases
Humans
Incidence
Intensive Care Units
Laparotomy
Length of Stay
Lung Transplantation
Male
Middle Aged
Postoperative Complications
Pulmonary Emphysema
Retrospective Studies
Risk Factors
Time Factors
Treatment Outcome
Young Adult
alpha 1-Antitrypsin Deficiency

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10.1016/j.healun.2014.02.025

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@article{aca6aaa4466e4d1cb165960a5e80a26b,

title = "Early laparotomy after lung transplantation: Increased incidence for patients with α1-anti-trypsin deficiency",

abstract = "Background Gastrointestinal complications after lung transplantation have been reported with incidence rates ranging from 3% to 51%, but the reasons are poorly understood. We aimed to investigate the correlations between pulmonary diseases leading to lung transplantation and early gastrointestinal complications requiring laparotomy after transplantation with outcomes for patients at increased risk. Methods In this study we performed a retrospective analysis of data of patients who underwent lung transplantation at our institution from 2004 to 2012. The study period was limited to the first 90 days after transplantation. Results Lung transplantation was performed in 258 patients, including 51 patients with α1-anti-trypsin deficiency (A1AD). Seventy-eight patients (30%) had an X-ray of the abdomen, and 23 patients (9%) required laparotomy during the first 90 days after transplantation. Patients with A1AD comprised 20% of the total recipients, 23% (18 of 78) of the patients who had an abdominal X-ray performed (p = 0.40), and 48% (11 of 23) of the patients who required laparotomy (p < 0.001). More than 1 of every 5 patients (11 of 51) with A1AD required laparotomy at a median 8 days after transplantation, and the estimated odds ratio for laparotomy for A1AD patients was 5.74 (CI 2.15 to 15.35). In the group of patients with A1AD who required laparotomy, the estimated hazard ratio for death was 1.62 (CI 0.57 to 4.62), the stay in the intensive care unit was prolonged, but no significant difference was observed for time on mechanical ventilation. Among pulmonary diseases and demographics of the patients, no other risk factors were identified for laparotomy. Conclusions A1AD was the only significant risk factor identified for gastrointestinal complications that required laparotomy within 3 months after lung transplantation. There was a trend toward a higher risk of death after laparotomy in patients with A1AD, and the length of stay in the intensive care unit was significantly prolonged, whereas the time on mechanical ventilation was unaffected.",

keywords = "Adolescent, Adult, Child, Female, Gastrointestinal Diseases, Humans, Incidence, Intensive Care Units, Laparotomy, Length of Stay, Lung Transplantation, Male, Middle Aged, Postoperative Complications, Pulmonary Emphysema, Retrospective Studies, Risk Factors, Time Factors, Treatment Outcome, Young Adult, alpha 1-Antitrypsin Deficiency",

author = "Pia Bredahl and Mikhail Zemtsovski and Michael Perch and Pedersen, {Dorte Levin} and Allan Rasmussen and Daniel Steinbr{\"u}chel and J{\o}rn Carlsen and Martin Iversen",

year = "2014",

month = jul,

doi = "10.1016/j.healun.2014.02.025",

language = "English",

volume = "33",

pages = "727--733",

journal = "Journal of Heart and Lung Transplantation",

issn = "1053-2498",

publisher = "Elsevier",

number = "7",

}

TY - JOUR

T1 - Early laparotomy after lung transplantation

T2 - Increased incidence for patients with α1-anti-trypsin deficiency

AU - Bredahl, Pia

AU - Zemtsovski, Mikhail

AU - Perch, Michael

AU - Pedersen, Dorte Levin

AU - Rasmussen, Allan

AU - Steinbrüchel, Daniel

AU - Carlsen, Jørn

AU - Iversen, Martin

PY - 2014/7

Y1 - 2014/7

N2 - Background Gastrointestinal complications after lung transplantation have been reported with incidence rates ranging from 3% to 51%, but the reasons are poorly understood. We aimed to investigate the correlations between pulmonary diseases leading to lung transplantation and early gastrointestinal complications requiring laparotomy after transplantation with outcomes for patients at increased risk. Methods In this study we performed a retrospective analysis of data of patients who underwent lung transplantation at our institution from 2004 to 2012. The study period was limited to the first 90 days after transplantation. Results Lung transplantation was performed in 258 patients, including 51 patients with α1-anti-trypsin deficiency (A1AD). Seventy-eight patients (30%) had an X-ray of the abdomen, and 23 patients (9%) required laparotomy during the first 90 days after transplantation. Patients with A1AD comprised 20% of the total recipients, 23% (18 of 78) of the patients who had an abdominal X-ray performed (p = 0.40), and 48% (11 of 23) of the patients who required laparotomy (p < 0.001). More than 1 of every 5 patients (11 of 51) with A1AD required laparotomy at a median 8 days after transplantation, and the estimated odds ratio for laparotomy for A1AD patients was 5.74 (CI 2.15 to 15.35). In the group of patients with A1AD who required laparotomy, the estimated hazard ratio for death was 1.62 (CI 0.57 to 4.62), the stay in the intensive care unit was prolonged, but no significant difference was observed for time on mechanical ventilation. Among pulmonary diseases and demographics of the patients, no other risk factors were identified for laparotomy. Conclusions A1AD was the only significant risk factor identified for gastrointestinal complications that required laparotomy within 3 months after lung transplantation. There was a trend toward a higher risk of death after laparotomy in patients with A1AD, and the length of stay in the intensive care unit was significantly prolonged, whereas the time on mechanical ventilation was unaffected.

AB - Background Gastrointestinal complications after lung transplantation have been reported with incidence rates ranging from 3% to 51%, but the reasons are poorly understood. We aimed to investigate the correlations between pulmonary diseases leading to lung transplantation and early gastrointestinal complications requiring laparotomy after transplantation with outcomes for patients at increased risk. Methods In this study we performed a retrospective analysis of data of patients who underwent lung transplantation at our institution from 2004 to 2012. The study period was limited to the first 90 days after transplantation. Results Lung transplantation was performed in 258 patients, including 51 patients with α1-anti-trypsin deficiency (A1AD). Seventy-eight patients (30%) had an X-ray of the abdomen, and 23 patients (9%) required laparotomy during the first 90 days after transplantation. Patients with A1AD comprised 20% of the total recipients, 23% (18 of 78) of the patients who had an abdominal X-ray performed (p = 0.40), and 48% (11 of 23) of the patients who required laparotomy (p < 0.001). More than 1 of every 5 patients (11 of 51) with A1AD required laparotomy at a median 8 days after transplantation, and the estimated odds ratio for laparotomy for A1AD patients was 5.74 (CI 2.15 to 15.35). In the group of patients with A1AD who required laparotomy, the estimated hazard ratio for death was 1.62 (CI 0.57 to 4.62), the stay in the intensive care unit was prolonged, but no significant difference was observed for time on mechanical ventilation. Among pulmonary diseases and demographics of the patients, no other risk factors were identified for laparotomy. Conclusions A1AD was the only significant risk factor identified for gastrointestinal complications that required laparotomy within 3 months after lung transplantation. There was a trend toward a higher risk of death after laparotomy in patients with A1AD, and the length of stay in the intensive care unit was significantly prolonged, whereas the time on mechanical ventilation was unaffected.

KW - Adolescent

KW - Adult

KW - Child

KW - Female

KW - Gastrointestinal Diseases

KW - Humans

KW - Incidence

KW - Intensive Care Units

KW - Laparotomy

KW - Length of Stay

KW - Lung Transplantation

KW - Male

KW - Middle Aged

KW - Postoperative Complications

KW - Pulmonary Emphysema

KW - Retrospective Studies

KW - Risk Factors

KW - Time Factors

KW - Treatment Outcome

KW - Young Adult

KW - alpha 1-Antitrypsin Deficiency

U2 - 10.1016/j.healun.2014.02.025

DO - 10.1016/j.healun.2014.02.025

M3 - Journal article

C2 - 24709270

SN - 1053-2498

VL - 33

SP - 727

EP - 733

JO - Journal of Heart and Lung Transplantation

JF - Journal of Heart and Lung Transplantation

IS - 7

ER -

Early laparotomy after lung transplantation: Increased incidence for patients with α1-anti-trypsin deficiency

Abstract

Keywords

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